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Medicine

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CAR T cell, chimeric antigen receptor, Cancer, Lymphoma, Stem Cell, Novartis, cancer expert, University of Chicago Medicine, Remission, Cancer Cure, FDA

Dr. Bishop @Uchicagomed Knows CAR T-Cell Therapy Backward and Forward

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Medicine

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University of Chicago Medicine, University of Chicago Medical Center, Acute Lymphoblastic Leukemia, Chimeric antigen receptor T-cell, CAR T, CAR T-cell therapy, CAR T cell, Food And Drug Administration, Novartis, Kymriah, John Cunningham, University of Chicago Medicine Comprehensive Cancer Center, Diffuse large B-cell lymphoma

UChicago Medicine Working to Offer Breakthrough CAR T-Cell Gene Therapy Approved Today by FDA

The University of Chicago Medicine is one of a limited number of U.S. sites working to offer a breakthrough gene therapy for pediatric acute lymphoblastic leukemia (ALL), which was just approved by the U.S. Food and Drug Administration.

Medicine

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crizotinib, crizotinib MET, dara aisner, gene fusion cancer, kurtis davies, MET cancer, MET gene, MET lung cancer, precision medicine lung cancer, Robert Doebele, terry ng, university of colorado cancer center

New Approach to Genetic Testing Matches Lung Cancer Patient with Life-Saving Drug

A University of Colorado Cancer Center case study published today in the journal JCO Precision Oncology tests for alterations in many genes simultaneously, matching stage IV lung cancer patient with life-saving drug

Medicine

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Warwick, Cancer, Warwick Medical School, Gene, Fusion, Gene Fusion

Study Highlights New Link Between Gene Fusion and Bladder and Brain Cancer

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A study by the University of Warwick sheds new light on gene fusion in bladder and brain cancer. Researchers have found that a previously overlooked part of a specific gene fusion has a worsening effect on cancer cells. They have also found that preventing cell ‘signalling’ from this particular fusion may not be an effective route for future cancer treatment research.

Medicine

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Pediatric Orthopedics, HME, hereditary multiple exostoses, osteochondromas, Genetics, Musculoskeletal Disorders, BMP Signaling

Findings in Animal Models May Lead to Novel Treatment for a Disabling Bone Disease

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Scientists at Children’s Hospital of Philadelphia report that a drug candidate that blocks abnormal protein signals may lead to the first pharmacologic treatment for hereditary multiple exostoses (HME), a rare pediatric genetic disease. HME causes multiple, disabling bone outgrowths (called exostoses or osteochondromas) and skeletal deformities, and such drugs could potentially spare patients the prospect of numerous, sometimes difficult childhood surgeries, while also reducing their risk of cancer.

Science

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Woolly Rhino, Woolly Mammoth, Paleontology, Extinct Species

Woolly Rhino Neck Ribs Provide Clues About Their Decline and Eventual Extinction

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Researchers from the Naturalis Biodiversity Center in Leiden examined woolly rhino and modern rhino neck vertebrae from several European and American museum collections and noticed that the remains of woolly rhinos from the North Sea often possess a ‘cervical’ (neck) rib—in contrast to modern rhinos. The study, published in the open access journal PeerJ today, reports on the incidence of abnormal cervical vertebrae in woolly rhinos. Given the considerable birth defects that are associated with this condition, the researchers argue it is very possible that developmental abnormalities contributed towards the eventual extinction of these late Pleistocene rhinos.

Medicine

Science

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age of first drink, early drinking, Alcohol Use Disorder, Ethnicity, alcohol and ethnicity, ALDH2*2, genetics and addiction, Korean American, Chinese American, European ancestry

Genetics and Ethnicity Can Influence Pathway between Early Drinking and Alcohol Use Disorders

Studies have shown that an early age of drinking initiation (ADI) increases the chance of developing an alcohol use disorder (AUD). There is limited evidence that ADI differs across ethnic groups. This study examined whether the pathway from ADI to AUD symptoms by early adulthood is influenced by two factors: ethnicity and having the alcohol metabolizing gene variant allele, ALDH2*2. This allele produces an inactive enzyme that leads to higher levels of acetaldehyde during alcohol metabolism, which are associated with unpleasant effects after drinking alcohol and a decreased risk for an AUD.

Medicine

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energetics, Mitochondria, Mtdna, DNA, Paternal Mitochondria, Mammalian Reproduction, Physiological Bioenergetics: Mitochondria from Bench to Bedside, Bioenergetics 2017, Bioenergetics17

Mom’s, Not Dad’s, Mitochondria Create Healthy Embryos

Mammal embryos shed paternal mitochondria within days of fertilization, perhaps to ensure the offspring a healthy life, a new study shows. Researchers from the California Institute of Technology will present their findings today at the American Physiological Society’s Physiological Bioenergetics: Mitochondria from Bench to Bedside conference in San Diego.

Medicine

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Gene Therapy, LeXis, Junk Dna, lncRNAs , Cholesterol, Heart Disease, familial hypercholesterolemia, Low Density Lipoprotein (Ldl) Levels

Gene Therapy Using ‘Junk DNA’ Could Lower Risk for Heart Disease

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Researchers successfully used a gene that suppresses cholesterol levels as part of a treatment to reduce plaque in mice with a disorder called familial hypercholesterolemia. In a preclinical study, researchers found that the gene, LeXis, lowered cholesterol and blockages in the arteries, and the treatment appeared to reduce the build-up of fat in liver cells.

Science

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Plasma Instability, Carbon Nanotubes, Radiological Crimes, and More in the DOE Science News Source

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