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Article ID: 694225

New CAR T Case Study Shows Promise in Acute Myeloid Leukemia

Moffitt Cancer Center

TAMPA, Fla. – Chimeric Antigen Receptor T-cell therapy, also known as CAR T therapy, was named the biggest research breakthrough of 2017 by the American Society of Clinical Oncology. The personal gene therapy utilizes a patient’s own immune cells to fight cancer. The Food and Drug Administration has approved CAR T therapy products for adults with diffuse large B-cell lymphoma and pediatric and young adults suffering from acute lymphoblastic leukemia.

Released:
9-May-2018 10:00 AM EDT
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Article ID: 694258

Mount Sinai Launches the i3 Asset Accelerator to Advance the Development of Life-Saving Discoveries

Mount Sinai Health System

The i3 Asset Accelerator is a new fund that fast-tracks select research discoveries to reach patients sooner, and has selected its first two projects to receive funding in 2018.

Released:
9-May-2018 9:05 AM EDT
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Article ID: 694234

Blocking the Molecular Source of Idiopathic Pulmonary Fibrosis

Michigan Medicine - University of Michigan

Successfully tested in mice, targeted drug and gene therapies might one day benefit patients with a deadly lung disease, new Michigan Medicine research finds.

Released:
9-May-2018 4:30 AM EDT
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Article ID: 694243

Zebrafish for Toxicology Testing, Dietary Intervention for Pulmonary Injury & In Vitro Screening Featured in ToxSci

Society of Toxicology

New Toxicological Sciences features a historical perspective and contemporary review of zebrafish as a model in toxicology. There also are highlighted papers on dietary intervention for pulmonary injury; PBPK modeling for PFOA risk; IVIVE and toxicokinetics; and microelectrode arrays and seizures.

Released:
8-May-2018 5:30 PM EDT
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Article ID: 694238

Metastasis Enablers: Findings Could Unlock New Ovarian Cancer Treatments

University of Wisconsin-Madison

New research from the lab of Pamela Kreeger, a University of Wisconsin-Madison biomedical engineering professor, has identified one way ovarian cancer cells appear to successfully spread.

Released:
8-May-2018 4:45 PM EDT
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Article ID: 694202

How Epigenetic Regulation of the Hoxb Gene Cluster Maintains Normal Blood-forming Stem Cells and Inhibits Leukemia

Stowers Institute for Medical Research

New research from the Stowers Institute for Medical Research reveals that a DNA regulatory element within the Hoxb cluster globally mediates signals to the majority of Hoxb genes to control their expression in blood-forming stem cells.

Released:
8-May-2018 12:05 PM EDT
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  • Embargo expired:
    8-May-2018 11:00 AM EDT

Article ID: 693869

Tissue Engineered Human Pancreas Cells Successfully Treat Diabetic Mice

Cincinnati Children's Hospital Medical Center

Researchers tissue-engineered human pancreatic islets in a laboratory that develop a circulatory system, secrete hormones like insulin and successfully treat sudden-onset type 1 diabetes in transplanted mice. In a study published by Cell Reports, the scientists use a new bioengineering process they developed called a self-condensation cell culture. The technology helps nudge medical science closer to one day growing human organ tissues from a person’s own cells for regenerative therapy

Released:
2-May-2018 11:30 AM EDT
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  • Embargo expired:
    8-May-2018 9:00 AM EDT

Article ID: 693863

Amplification of Key Cellular Organizer May Initiate Cancer, Study Suggests

The Rockefeller University Press

Cells begin to accumulate centrosomes—organelles that play a vital role during cell division—before they transform into cancer cells, according to a new study of patients with Barrett’s esophagus condition, which is associated with esophageal cancer. The research, which will be published May 8 in the Journal of Cell Biology, suggests that similar cases of centrosome amplification may contribute to the initiation and progression of a variety of human cancers.

Released:
2-May-2018 10:10 AM EDT
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  • Embargo expired:
    8-May-2018 8:00 AM EDT

Article ID: 693636

What Does a ‘Normal’ Voice Sound Like?

Acoustical Society of America (ASA)

Humans communicate their intentions, feelings and desires verbally, so voice disorders can have devastating personal and professional consequences. A perceived voice abnormality may lead to a negative assessment of the speaker’s intelligence, health and personality. During the 175th ASA Meeting, researchers will describe their work on voice perception and what it means for a voice to sound “normal.”

Released:
27-Apr-2018 10:05 AM EDT
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Article ID: 694180

Fred Hutch Tip Sheet: Epstein-Barr Virus, CMV Breakthroughs, Immunotherapy Advances, Brain Cancer and Head and Neck Tumors

Fred Hutchinson Cancer Research Center

This month's tip sheet from Fred Hutchinson Cancer Research Center includes story ideas about moving toward a vaccine for Epstein-Barr virus, tissue samples from 1989 that have led to CMV breakthroughs today, immunotherapy advances and research related to brain cancer and head and neck tumors.

Released:
7-May-2018 7:05 PM EDT
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