UCI researchers identified a gene critical for muscle repair, paving the way for lab-grown muscle to treat muscle disorders and injuries.
A multicenter study led by researchers at Sylvester Comprehensive Cancer Center shows how interactions between tumor cells and immune components of the microenvironment can impact treatment responses and outcomes in patients newly diagnosed with multiple myeloma who undergo combination treatments that include targeted immunotherapy.
Researchers at Lund University, together with colleagues at the NIST Synchrotron Facility in the USA, have mapped on an atomic level what happens in a virus particle when the temperature is raised.
Scientists synthesize a yeast chromosome as part of a global project to create the world's first synthetic eukaryotic genome.
Waterhemp, the aggressive weed threatening Corn Belt crop production, is throwing curveballs once again, according to researchers at the University of Illinois Urbana-Champaign. The weed has famously developed resistance to not one or two, but seven herbicide sites-of-action classes, nearly exhausting the chemical tools farmers can use to defend their livelihood.
Children’s Hospital Los Angeles has launched a new clinical trial to investigate a potential treatment for Dup15q syndrome, a rare genetic condition that causes developmental delays, autism spectrum disorder and epilepsy.
SMU nanotechnology expert MinJun Kim and his team have been awarded a $1.8 million, R01 grant from the National Institutes of Health (NIH) for research related to gene therapy.
Whole genome sequencing of North American song sparrows has revealed the genetic underpinnings for a stunning range of body sizes found throughout the bird’s westernmost range—an adaptation that may make the birds more resilient to climate change. This work is the first output from a larger research effort to sequence song sparrow genomes from across North America, spanning nearly all of the 25 recognized subspecies.
The November issue of AJG highlights new clinical science and reviews including additional colonoscopy quality measures, higher infliximab concentrations in IBD patients with higher visceral adipose tissue (VAT), an automated tissue systems pathology test for Barrett’s esophagus, and opioid-related constipation.
Simon Fraser University researchers studying the evolutionary history of flu viruses have found that a new quantitative analysis of how they evolved may help predict future strains.
Researchers have sequenced the genome of the fungus causing tar spot on corn and identified key genes involved in disease development. This information will help researchers develop better disease management strategies.
Investigators from the Department of Neurosurgery at Cedars-Sinai have determined that exposure to polluted air could accelerate development of Alzheimer’s disease in those with genetic risk factors for the neurodegenerative condition.
Compact genetic testing device created for Covid-19 could be used to detect a range of pathogens, or conditions including cancer
Researchers at the Francis Crick Institute and the Université Cote d’Azur, together with other labs in France and Switzerland, have identified a gene which is an early determining factor of ovary development in mice.
The development of sex-specific characteristics is frequently seen in mammals. These characteristics stem from the activation of corresponding genetic programmes that until now have been largely undescribed by the scientific community.
Phenylketonuria (PKU) is a rare newborn genetic disease that impacts between 1 in 10,000 to 1 in 20,000 people, depending on the individuals’ genetic ancestry. PKU causes an amino acid—called phenylalanine (Phe)—to build up in the bloodstream.
In research published in Nature Catalysis, scientists at Florida State University produced the first high-resolution, time-lapsed images showing magnesium ions interacting with the CRISPR-Cas9 enzyme while it cut strands of DNA, providing clear evidence that magnesium plays a role in both chemical bond breakage and near-simultaneous DNA cutting.
In an invited commentary, Kathleen Mulvaney, assistant professor with the Fralin Biomedical Research Institute at VTC, talks about the potential of a new drug that has shown early promise in clinical trials for solid tumors by killing cancer cells that lack specific tumor suppressor genes.
Being taller during the course of a person’s lifetime could protect against heart disease and stroke in later life, according to a new University of Bristol-led study. The research, which analysed height and genetic data on over 454,000 individuals, is published in the pre-print publication* medRxiv.
Urinary biomarkers have the potential to surpass serum biomarkers in disease diagnosis and monitoring. This review highlights their non-invasive, stable, and specific nature. It explores a range of urinary biomarkers, such as proteins, genes, metabolites, electrolytes, and extracellular vesicles, showing their superiority.
WSU study finds epigenetic signature in cheek cells of obese people, suggesting a biomarker test for obesity could be developed
In a Finnish study, significant differences in the gene activity of the foetal intestine, brain and placenta were identified, depending on the microbes in the mother’s body and the compounds produced by them. The findings indicate that maternal microbes are important to her offspring’s development and health
Dravet syndrome is a rare, severe epilepsy caused by certain changes in the SCN1A gene. But people with Dravet have a wide range of clinical characteristics that cannot be fully explained by these changes. What else is going on?
As people age, the DNA in their cells begins to accumulate genetic mutations. Mosaic chromosomal alterations (mCAs), a category of mutations acquired in blood cells, are linked with a 10-fold increased risk of developing blood cancer. mCAs hold promise as a tool to identify people at high risk of developing certain cancers and diseases, but they have not yet been studied among a large, diverse cohort of people – a critical step required before such testing can be developed. University of Kentucky Markey Cancer Center researcher Yasminka A. Jakubek, Ph.D., has led the first large-scale effort to understand the co-occurrence of mCAs among individuals of diverse ancestries. The study was published in Nature Genetics Oct. 30.
In an invited commentary, Kathleen Mulvaney, assistant professor with the Fralin Biomedical Research Institute at VTC, talks about the potential of a new drug that has shown early promise in clinical trials for solid tumors by killing cancer cells that lack specific tumor suppressor genes.
Adults and parents of children living with sickle cell disease suggest their acceptance of gene therapy risks grows significantly with condition severity.
A study led by researchers at Stony Brook University shows that age acceleration, when one’s so-called biological clock runs quicker than one’s actual age, is linked to poorer memory and slower rates of processing information. The team measured biological “clocks” derived from the DNA of 142 adults aged 25-65 years old and had the participants complete daily cognitive tests on smartphones. Their findings, which imply that epigenetic age acceleration could be a better indicator of how well a person remembers information and how quickly they work with information, are detailed in the Journal of Gerontology: Biological Sciences.
An international research team, including Jonathan C. Schisler, PhD, in the UNC School of Medicine, has found how SARS-CoV-2 causes widespread “energy outages” throughout major organs, and how these effects contribute to debilitating long COVID symptoms.
A new drug developed by professors from the School of Pharmacy and Pharmaceutical Sciences at Binghamton University, State University of New York has received FDA approval for the treatment of patients with Duchenne muscular dystrophy, a common genetic disease that mostly affects young boys.
The Icahn School of Medicine at Mount Sinai will award its 2023 Maria I. New International Prize for Biomedical Research to Jean-Laurent Casanova, MD, PhD, for revolutionizing our understanding of human infectious diseases through the discovery of genetic and immunological determinants that underpin both rare and common infectious illnesses. The prize honors medical pioneers in the tradition of Maria I. New, MD, a world-renowned researcher in pediatric genetic disorders with a special focus on endocrinology over her six-decade career. Dr. Casanova will receive a prize of $20,000 and will present the Maria I. New Distinguished Lecture during a ceremony to be held in at Icahn Mount Sinai in New York City on November 21, 2023.
CRISPR-Cas9-based genome editing offers hope for treating severe immunodeficiency disorders like SCID, with a novel approach for precise gene replacement, reducing risks and potentially aiding various genetic diseases.
A novel replacement strategy termed GE x HDR 2.0: Find and Replace, developed by researchers from Bar-Ilan University and described in published today in Nature Communications, combines CRISPR-Cas9-mediated genome editing with recombinant adeno-associated serotype 6 (rAAV6) DNA donor vectors to precisely replace the RAG2 coding sequence while preserving regulatory elements.
Researchers at Indiana University Melvin and Bren Simon Comprehensive Cancer Center are unlocking the biology behind aggressive breast cancers in Black women.
Gene therapy currently represents the most promising approach for the treatment of hereditary diseases. Yet despite significant breakthroughs in recent years, there are still a number of hurdles that hinder the wider application of gene therapies.
Harnessing new advances in genomic surveillance technology could help detect the rise of deadly ‘superbugs’
Scientists discover genes that help kingfishers dive without hurting their brains
Risk-averse on/off-target assessment for CRISPR editing without reference genome
For tens of thousands of years, evolution shaped tomatoes through natural mutations. Then, humans came along. For centuries, we’ve bred and cherry-picked tomatoes with our preferred traits.
Researchers hope at least one will treat progressive blindness caused by Usher syndrome type 1F
Científicos de Mayo Clinic están creando una biblioteca extensa de prototipos de ADN de especies bacterianas patógenas. Esta colección única de secuencias genómicas sirve como base de datos de referencia para ayudar a los médicos a brindar diagnósticos certeros y rápidos, y a precisar tratamientos dirigidos para, posiblemente, mejorar los resultados que obtienen los pacientes.
Genetic evidence looked at how salmon were affected by two major culvert replacements near the city of Bellingham. One project, a major upgrade under Interstate-5, had a big impact, while the other old culvert may have been less of a barrier to fish. Researchers at the University of Washington and NOAA are studying the use of eDNA in future environmental impact reporting.
Women with a high genetic predisposition for blood clots are six times more likely to develop a blood clot during the first two years of using contraceptive pills according to a new study from Uppsala University. The results have been published in the American Journal of Obstetrics and Gynaecology
About 40,000 years ago, Neanderthals, who had lived for hundreds of thousands of years in the western part of the Eurasian continent, gave way to Homo sapiens, who had arrived from Africa.
New research examines the complex relationship between gene variants, cardiorespiratory fitness and the development of chronic disease. The study is published ahead of print in Physiological Genomics. It was chosen as an APSselect article for October.
Octopuses are fascinating animals – and serve as important model organisms in neuroscience, cognition research and developmental biology. To gain a deeper understanding of their biology and evolutionary history, validated data on the composition of their genome is needed, which has been lacking until now.
A new genomic study by UCLA biologists shows that whaling in the 20th century destroyed 99% of the Eastern North Pacific fin whale breeding, or “effective,” population — 29% more than previously thought.
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