Some devastating diseases, like Alzheimer's and autoimmune conditions, are hard to diagnose correctly because doctors don’t yet know what genes or molecules to look for. But a new technique inspired by the Star Trek tricorder can spot disease without the clues, using infrared light and machine learning.
Researchers report that a drug approved for treating patients with autoimmune disease helped to prevent lung damage and death in mice infected with the SARS-CoV-2 virus, which causes COVID-19 in humans.
Regulating the endothelin system may help inflammatory conditions. Studies found improvements in lupus, colitis and kidney injury mouse models. Findings will be presented virtually at the Seventeenth International Conference on Endothelin, hosted and organized by the American Physiological Society.
University at Buffalo researchers have developed a new treatment that uses reverse vaccination to pre-expose the body to medications and build immune tolerance. The treatment could be applied to a broad range of drug therapies, autoimmune disorders and allergies.
To mark its 30-year legacy and global impact on the autoimmune community, today, the American Autoimmune Related Diseases Association (AARDA) is pleased to announce its new name: the Autoimmune Association.
New research shows that Multiple Sclerosis (MS) patients undergoing anti-CD20 (aCD20) treatment – which depletes the B cells that contribute to the MS attacks – are able to mount robust T-cell responses to the mRNA COVID-19 vaccines, despite having a muted antibody response to the vaccines.
Researchers at Washington University School of Medicine in St. Louis have genetically engineered cells that, when implanted in mice, deliver a biologic drug in response to inflammation.
Two National Institute of Health (NIH) grants totaling over $1.3 million will enable research into antibody-mediated drug delivery technology for the treatment of cancer and autoimmune disorders. L. Nathan Tumey, assistant professor of pharmaceutical sciences, is the Principal Investigator on both grants — $1.2 million from the National Institute of General Medical Sciences and $150,000 from the National Institute of Allergy and Infectious Diseases.
A Michigan Medicine physician will co-lead a NIH study of antibody response to an additional dose of the COVID-19 vaccine in people with autoimmune disease. The trial will also assess whether pausing immunosuppressive medication improves immune response to the booster shot.
Expert Q&A: Do breakthrough cases mean we will soon need COVID boosters? The extremely contagious Delta variant continues to spread, prompting mask mandates, proof of vaccination, and other measures. Media invited to ask the experts about these and related topics.
The absence of a protein that activates the body’s antiviral defenses can cause a rare rheumatoid-like autoinflammatory condition that is treatable with an FDA-approved class of drugs known as TNF (tumor necrosis factor) inhibitors, a global research team led by Mount Sinai has found.
The FDA and CDC have just approved and recommended an additional dose of mRNA COVID-19 vaccines for moderately and severely immunocompromised people. Who should get it?
CorEvitas, LLC, the leading sponsor of registries in autoimmune and inflammatory diseases announces first patient enrollment in a new biospecimen study for patients enrolled in its rheumatology registries. Eligible rheumatology registry patients will contribute biological specimens that will be linked to longitudinal provider reported clinical and patient reported outcomes.
How effective COVID-19 vaccines have been in immunosuppressed and rheumatic disease patients remains an incompletely answered question. The American College of Rheumatology (ACR) has organized an expert panel to share what we are learning from real-world data and answer questions.
The US Food and Drug Administration approved the drug anifrolumab (Saphnelo) on August 2, 2021 for the treatment of adult patients with moderate to severe systemic lupus erythematosus (SLE) who are receiving standard therapy. Much of the groundwork for the development of this drug was done in laboratories at Hospital for Special Surgery (HSS) in the early 2000s.
Regulatory T cells (Tregs) help control inflammation and autoimmunity in the body. Unfortunately, it has proven difficult to find the right molecular ingredients to induce stable iTregs. A new study reports that Vitamin C and TET proteins can work together to give Tregs their life-saving power.
In a new University of California, Irvine-led study, researchers found that a certain protein prevented regulatory T cells (Tregs) from effectively doing their job in controlling the damaging effects of inflammation in a model of multiple sclerosis (MS), a devastating autoimmune disease of the nervous system.
Diagnosing a rare medical condition is difficult. Identifying a treatment for it can take years of trial and error. In a serendipitous intersection of research expertise, an ill patient in this case a child and innovative technology, Bachmann-Bupp Syndrome has gone from a list of symptoms to a successful treatment in just 16 months.
Researchers at Michigan Medicine have discovered another functional autoantibody in COVID-19 patients that contributes to the disease’s development and the “firestorm” of blood clots and inflammation it induces. The autoantibody makes it harder for the body to degrade neutrophil extracellular traps, the toxic webs of DNA and proteins produced by overactive immune cells at heightened levels in COVID patients.
Did you know multiple sclerosis (MS) means multiple scars? New research shows that the brain and spinal cord scars in people with MS may offer clues to why they developprogressive disability but those with related diseases where the immune system attacks the central nervous system do not. In a study published in Neurology, Mayo Clinic researchers and colleagues assessed if inflammation leads to permanent scarring in these three diseases:
Nanofiber-based treatments stimulate the body to mount its own biological attack on immune disorders.
The American Autoimmune Related Diseases Association (AARDA), the world’s leading nonprofit organization dedicated to autoimmune awareness, advocacy, education, and research, appointed Molly Murray, CAE as President and CEO. Murray will lead AARDA’s efforts to bring a national focus to autoimmunity, the major cause of over 100 serious chronic diseases.
مدينة روتشستر، ولاية مينيسوتا- أطلقت مختبرات مايو كلينك اختبارًا للمناعة الذاتية هو الأول من نوعه للجسم المضاد KLHL11، أو البروتين 11 المشابه للكيلتش، والذي يستخدم للكشف عن أمراض المناعة الذاتية المرتبطة بسرطان الخصية. وهذا الاختبار متاح محليًا ودوليًا.
Os Laboratórios da Mayo Clinic divulgaram um teste autoimune inédito para o anticorpo da proteína 11 do tipo Kelch, ou KLHL11, usado para detectar uma doença autoimune associada ao câncer testicular. O teste está disponível nacional e internacionalmente.
Scleroderma has taken both of Lovette Twyman Russell's lungs and the tips of three of her fingers, but not one ounce of her joy in life. For the 58-year-old former triathlete, getting the right treatment for this rare autoimmune disease – which causes abnormal growth of connective tissue and can permanently damage the joints, skin, cartilage and internal organs – has made all the difference.
Los Laboratorios de Mayo Clinic pusieron en marcha la primera prueba autoinmunitaria en su clase para el anticuerpo contra la proteína tipo Kelch 11 (KLHL11), que sirve para detectar una enfermedad autoinmunitaria relacionada con el cáncer de testículo. La prueba está disponible a nivel nacional e internacional.
The American Autoimmune Related Diseases Association (AARDA) has been approved for a $97,498 funding award through the Eugene Washington PCORI Engagement Awards program, an initiative of the Patient-Centered Outcomes Research Institute (PCORI).
Mayo Clinic Laboratories has launched a first-of-its-kind autoimmune test for the Kelch-like protein 11 antibody, or KLHL11, which is used to detect autoimmune disease associated with testicular cancer. The test is available nationally and internationally.
The American Autoimmune Related Diseases Association (AARDA) announced six new board members and two new advisors to the board. Each will help support AARDA’S mission of improving the lives affected by autoimmune disease, through awareness, education, advocacy, and research.
An international team of researchers, led by UC Davis Health, developed a new therapeutic approach to treating psoriatic arthritis, a chronic inflammatory disease affecting the joints.
The American Autoimmune Related Disease Association (AARDA) hosted the 15th Noel Rose Scientific Colloquium on May 1, 2021, bringing together high-level researchers from different areas and specialties.
A groundbreaking study led by engineering and medical researchers at the University of Minnesota Twin Cities shows how engineered immune cells used in new cancer therapies can overcome physical barriers to allow a patient’s own immune system to fight tumors. The research could improve cancer therapies in the future for millions of people worldwide.
Researchers have developed first-in-class small-molecule inhibitors against a key leukemia protein, ASH1L.
Scientists are rapidly gathering evidence that variants of gut microbiomes, the collections of bacteria and other microbes in our digestive systems, may play harmful roles in diabetes and other diseases.
During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every other Wednesday.
Programs that provide ongoing support to patients with painful conditions and complex medication regimens may also help them avoid using potentially risky opioid pain medications, or reduce the amount they use, a new study finds.
A combination of inexpensive oral medications may be able to treat fatigue-inducing anemias caused by chronic diseases and inflammation, a new discovery from the University of Virginia School of Medicine suggests.
In a study by Yale Cancer Center, researchers report on the discovery of a common mechanism that promotes both autoimmune diseases and blood cancers, including the blood diseases Acute Lymphoblastic Leukemia (ALL), Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL).
A phase 3 clinical trial finds an anti-inflammatory drug used in rheumatoid arthritis can preserve lung function in patients with systemic sclerosis.
Inhibiting IRE1α, a molecule activated by the endoplasmic reticulum in neutrophils, counters disease progression in lupus mice.
The new approach blocks the interaction between cancer cells and immune receptors, showing promise in mice.
Corrona, LLC, a leading provider of real-world evidence solutions, announced today that it has changed its name to CorEvitas [kohr-eh'-vi-tahs].
Translational research led by scientists at La Jolla Institute for Immunology (LJI) has resulted in a promising combination therapeutic candidate for adults with recent-onset type 1 diabetes.
The approval of COVID-19 vaccines has brought with it hope, excitement, as well as concerns. AARDA is committed to ensuring you have the information you need to make the right decisions for your health. A panel of medical experts will discuss frequently asked questions regarding COVID-19 vaccines, as well as address audience questions.
The March issue of The American Journal of Gastroenterology features new clinical research involving sex and gender, including effects of GI and liver conditions on pregnancy, gender disparities in diet and nutrition, Barrett’s esophagus incidence in women with scleroderma, factors influencing whether women pursue advanced endoscopy careers, endoscopy-related musculoskeletal injuries, sex hormone association with increased prevalence of certain types of cancer, and more.
At the beginning of an immune response, a molecule known to mobilize immune cells into the bloodstream, where they home in on infection sites, rapidly shifts position, a new study shows. Researchers say this indirectly amplifies the attack on foreign microbes or the body’s own tissues.
A lab on UNLV’s campus has been a hub of activity in recent years, playing a significant role in a new realm of drug discovery — one that could potentially provide a solution for patients who have run out of options.
Slight differences in clinical features can help physicians distinguish between two rare but similar forms of autoimmune brain inflammation in children, a new study by UT Southwestern scientists suggests. The findings, published online in Pediatric Neurology, could provide patients and their families with a better prognosis and the potential to target treatments specific to each condition in the future.
Patients with COVID-19 are at risk for neurologic complications, including encephalitis, or inflammation of the brain. "Encephalitis cases have been reported in patients with COVID-19, although on the whole it appears to be a relatively rare complication," says Michel Toledano, M.D., a Mayo Clinic neurologist. In the case of encephalitis caused by communicable diseases for which there is a vaccine available, getting vaccinated is the best way of preventing the disease.
The approval of COVID-19 vaccines has brought with it hope, excitement, as well as concerns. AARDA is committed to ensuring you have the information you need to make the right decisions for your health. A panel of medical experts will discuss frequently asked questions regarding COVID-19 vaccines, as well as address audience questions during our upcoming Autoimmune Newscast, “Should I Get the COVID-19 Vaccine?” on 2/26 at 2pm ET
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