Alzheimer’s disease (AD) is associated with damaging protein aggregates in the brain, with β-amyloid (Aβ) aggregates called plaques being the key pathology. Entresto (sacubitril/valsartan) is a combined neprilysin inhibitor and angiotensin receptor blocker, approved for the treatment of heart failure.
Nearly two in five U.S. adults have high cholesterol, according to the Centers for Disease Control and Prevention (CDC).
Northwestern University researchers have developed the first physics-based metric to predict whether or not a person might someday suffer an aortic aneurysm, a deadly condition that often causes no symptoms until it ruptures.
Prenatal diagnosis of congenital heart defects – the most common birth defects in the United States – is associated with improved outcomes. Despite its importance, however, overall prevalence of prenatal diagnosis is low (12-50 percent). A recent multi-center study surveyed caretakers of infants who received congenital heart surgery in the Chicago area and found that social determinants or influencers of health constitute significant barriers to prenatal diagnosis from the patients’ perspective.
Cerebral organoids are three-dimensional, in vitro cultured brains that mimic the activities of the human brain. They have emerged as invaluable tools to comprehend evolution, disease pathogenesis, and neurodevelopmental processes. However, the development of these organoids is still in nascent stages with several limitations that hinder their broad applications. A major obstacle is the absence of a functional vasculature that can restrict the size of organoids, trigger cell death, and prevent cell differentiation in the organoids.
An artificial intelligence (AI) tool developed by investigators at the Smidt Heart Institute at Cedars-Sinai and colleagues at two other institutions accurately predicted how patients would fare after surgeries and procedures.
Cardiovascular diseases are the leading cause of death in the world according to the Global Burden of Disease study, with 18.6 million annual deaths in 2019, of which around 7.9 are attributable to diet. This means that diet plays a major role in the development and progression of these diseases.
In a landmark study led by the University of Maryland School of Medicine, researchers discovered for the first time that a certain kind of protein similar to hemoglobin, called cytoglobin, plays an important role in the development of the heart.
The Smidt Heart Institute at Cedars-Sinai has expanded its popular Virtual Second Opinion Program to women living with or at risk of developing heart disease, the nation’s leading cause of death in women.
Increased sedentary time in childhood can raise cholesterol levels by two thirds as an adult, leading to heart problems and even premature death - but a new study has found light physical activity may completely reverse the risks and is far more effective than moderate-to-vigorous physical activity.
Childhood cancer survivors have a higher prevalence of prediabetes and diabetes, which increases their risk of serious disease but also offers opportunities for prevention.
An analysis of death certificate data from 1999 to 2020 showed a decline in deaths related to infective endocarditis throughout most of the United States yet found an alarming increase of 2%-5% among adults ages 25-44.
Published results of a large, national heart attack study show that patients with a life-threatening complication known as cardiogenic shock survived at a significantly higher rate when treated with a protocol developed by cardiologists at Henry Ford Health, in collaboration with 80 hospitals nationwide.
Renal dysfunction, especially chronic kidney disease, is the biggest risk factor of mortality among thrombolysed stroke patients, according to a retrospective cohort observational study published in Medicine®, a journal published in the Lippincott portfolio by Wolters Kluwer.
Infusions of potentially therapeutic cells derived from the heart are safe for people with pulmonary arterial hypertension, a form of high blood pressure that occurs in the blood vessels of the lungs and typically affects middle-aged women, according to a study led by Cedars-Sinai investigators.
Rating measures quality, safety, and outcomes of the five most common heart procedures
Children who are physically inactive may have high cholesterol in early adulthood and subsequent heart health issues in their mid-forties, according to new research published in The Journal of Clinical Endocrinology & Metabolism.
FluidForm Bio, a leader in developing life-like human tissue to treat disease, shares recent advancements in building human cardiac tissues using FRESH™ 3D bioprinting. Recently published in APL Bioengineering, the research article FRESH™ 3D bioprinted cardiac tissue, a bioengineered platform for in vitro pharmacology addresses the critical need for a predictive model of human cardiac physiology in drug development.
University of Virginia School of Medicine researchers have created an “atlas of atherosclerosis” that reveals, at the level of individual cells, critical processes responsible for forming the harmful plaque buildup that causes heart attacks, strokes and coronary artery disease.
Stem cell-based therapy improved quality of life for patients with advanced heart failure, Mayo Clinic researchers and international collaborators discovered in a late-stage multinational clinical trial.
Baylor Scott & White Heart and Vascular Hospital – Dallas has added an innovative, minimally invasive option for patients with hypertension, or high blood pressure.
A beating heart makes for a formidable surgical arena, but a new robotic catheter could someday equip surgeons to operate in the cardiac environment with greater ease.
Patients who received the anticoagulant drug warfarin after bioprosthetic aortic valve replacement had lower incidence of mortality and a decreased risk of blood clots, according to a retrospective study published in Mayo Clinic Proceedings.
A study of married or partnered, middle-aged and older heterosexual couples in the U.S., England, China and India found that in 20% to 47% of the couples, both spouses/partners had high blood pressure.
Awarded $4 million in NIH grants to study new therapies for improved survival
Studies show that those suffering from long COVID may benefit from physical therapy services as soon as they are able to tolerate physical activity, a PCOM Georgia assistant professor, who specializes in cardiopulmonary physical therapy, said.
David Epstein, MD, a pediatrician who has dedicated his career to caring for very ill children, has been selected as the new director of Pediatric and Congenital Cardiac Intensive Care at Cedars-Sinai Guerin Children’s.
Researchers have developed a prescription wristwatch that continuously monitors the wearer’s heart rhythm and uses a unique algorithm to detect atrial fibrillation.
A roundup of the latest medical discoveries and faculty news at Cedars-Sinai.
Rating measures quality, safety, and outcomes
Heart disease kills 18 million people each year, but the development of new therapies faces a bottleneck: no physiological model of the entire human heart exists – so far.
Heart failure is a potentially urgent health concern for young adults with congenital heart disease (ACHD) that is often overlooked and undertreated, even as hospitalizations for this condition continue to rise.
A dietary supplement developed by a UT Southwestern Medical Center researcher significantly reduced high blood sugar caused by a diuretic used to lower blood pressure while also correcting electrolyte imbalances, UTSW researchers report. The findings, published in Hypertension, could offer a solution for the serious side effects associated with this class of drugs.
The clinical trial, led by Mirnela Byku, MD, PhD, MBA, at the UNC School of Medicine, found that excluding aspirin from the antithrombotic regimen in patients with a levitated left ventricular assist device is safe.
Noted experts in cardiovascular rehabilitation attending the Third Jim Pattison-Mazankowski Alberta Heart Institute Cardiac Rehabilitation Symposium (Banff, April 21-23, 2023) observed that although cardiac rehabilitation benefits diverse groups of patients and affords the most cost-effective prevention for recurrent events, it is grossly underutilized globally.
A large proportion of patients who start taking ADHD medication, especially young adults, stop within the first year. However, people who use ADHD medicine for a long time and in higher-than-average doses seem to have a higher risk of some cardiovascular diseases.
Noted experts in cardiovascular rehabilitation attending the Third Jim Pattison-Mazankowski Alberta Heart Institute Cardiac Rehabilitation Symposium (Banff, April 21-23, 2023) observed that although cardiac rehabilitation benefits diverse groups of patients and affords the most cost-effective prevention for recurrent events, it is grossly underutilized globally.
In diseased hearts, low-dose radiation therapy appears to improve heart function. The research, from Washington University School of Medicine in St. Louis, could lead to new heart failure therapies.
A new study from the UW found that unfiltered air from rush-hour traffic significantly increased passengers’ blood pressure, both while in the car and up to 24 hours later.
New research helps explain the recent reversal in cardiovascular mortality among this population and underscores the need to address the social determinants of health that contribute to it.
A new study finds that alcohol consumption may have counteractive effects on cardiovascular disease risk, depending on the biological presence of certain circulating metabolites—molecules that are produced during or after a substance is metabolized and studied as biomarkers of many diseases.
Si usted corre el riesgo de enfermedad cardíaca, el equipo de atención médica podría utilizar la herramienta de la ecuación de cohorte agrupada para determinar su riesgo a largo plazo y si la administración de estatinas (medicamentos para reducir el colesterol) es una buena opción.
مدينة روتشستر، ولاية مينيسوتا—إذا كنت مهددًا بخطرالإصابة بمرض القلب فقد يستخدم فريق الرعاية الصحية أداة معادلة تقييم المخاطر المُشتركة بين الفئات العمرية(PCE) لتحديد خطر إصابتك على المدى الطويل وما إذا كان تناول أدوية خافِضة للكوليسترول — أدوية خفض الكوليستيرول، خيار مناسب لك أم لا.
Se você está sob o risco de ter uma doença cardíaca, a equipe de cuidados médicos pode usar a ferramenta de equação de coorte agrupada (PCE) para determinar o seu risco de longo prazo, e se a administração de estatinas (medicamentos para reduzir o colesterol) é uma boa opção.
This Thanksgiving marks a little more than 25 years since Christine Galan became the first person in the Western U.S. to have a combined organ transplant (heart and liver), and nearly five years since she returned to Cedars-Sinai for another organ transplant—this time, a kidney.
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