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Stem Cells

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Medicine

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Stem Cells, Epilepsy, Neurology, Neuroscience, medial ganglionic eminence Cells

Epilepsy Cured in Mice Using Brain Cells

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Epilepsy that does not respond to drugs can be halted in adult mice by transplanting a specific type of cell into the brain, UC San Francisco researchers have discovered, raising hope that a similar treatment might work in severe forms of human epilepsy.

Medicine

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Cancer, Stem Cells

Making Cancer Less Cancerous

Researchers at Johns Hopkins have identified a gene that, when repressed in tumor cells, puts a halt to cell growth and a range of processes needed for tumors to enlarge and spread to distant sites. The researchers hope that this so-called “master regulator” gene may be the key to developing a new treatment for tumors resistant to current drugs.

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Adult Cells Transformed Into Early-Stage Nerve Cells, Bypassing the Pluripotent Stem Cell Stage

A University of Wisconsin-Madison research group has converted skin cells from people and monkeys into a cell that can form a wide variety of nervous-system cells — without passing through the do-it-all stage called the induced pluripotent stem cell, or iPSC.

Science

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AANS Annual Scientific Meeting, American Association of Neurological Surgeons, AANS, Neurosurgery, Neurosurgeon, Neuroscience, Stem Cell Research, Stem Cell, Neural Stem Cell, Neural Stem Cell Transplantation, Myelin, Pelizaeus Merzbacher, myelination

Phase I Trial Results of Neural Stem Cell Transplantation Encouraging Those Suffering from Pelizaeus-Merzbacher Disease

Research findings show human central nervous system stem cells foster myelin formation following HuCNS-SC transplantation.

Medicine

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Stem Cell, Muscle, Obesity, Type 2 Diabetes, Muscular Dystrophy

Identification of Stem Cells’ Two Separate Roles Raises Possibility of Therapies That Could Inhibit Fat Formation, Promote Muscle Repair

Many diseases – obesity, Type 2 diabetes, muscular dystrophy – are associated with fat accumulation in muscle. In essence, fat replacement causes the muscles to weaken and degenerate. Scientists at Wake Forest Baptist Medical Center have discovered the biological mechanism involved in this process, which could point the way to potential therapies.

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Microglia Can Be Derived From Patient-Specific Human Induced Pluripotent Stem Cells and May Help Modulate the Course of Central Nervous System Diseases

Overall importance of microglia in various brain and spinal cord diseases surprises researchers, who find patient-specific stem cells can be turned into microglia, which could be very useful in future treatment options.

Science

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Stem Cells, Transdifferentiation, Spinal Cord Injuries, Stroke, Antibodies, cell therapies

Antibody Transforms Stem Cells Directly into Brain Cells

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In a serendipitous discovery, scientists at The Scripps Research Institute have found a way to turn bone marrow stem cells directly into brain cells.

Science

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pluripotent stem (iPS) cells , Mitochondria, Small Molecule, differentiated stem cells, protein translocation, ALR

UCLA Researchers Develop New Method for Purifying Stem Cells for Treatment

Pluripotent stem cells can turn (differentiate) into any cell type in the body, such as nerve, muscle or bone, but inevitably some of these stem cells fail to differentiate and end up mixed in with their newly differentiated daughter cells. UCLA scientists have discovered a new agent that may be useful in strategies to kill off pluripotent stem cells from differentiated daughter cells.

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Stem Cell Transplant Restores Memory, Learning in Mice

For the first time, human embryonic stem cells have been transformed into nerve cells that helped mice regain the ability to learn and remember.

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Researchers Discover that Stem Cell Senescence Drives Aging

Declining levels of the protein BubR1 occur when both people and animals age, and contribute to cell senescence or deterioration, weight loss, muscle wasting and cataracts.







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