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Stem Cells

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Medicine

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Transplanation, Lung Transplant, donor lungs, Biomedical Engineering, Tissue Engineering, Regenerative, Stem Cell

New Method Rescues Donor Organs to Save Lives

Researchers from Columbia Engineering and Columbia University Medical Center have—for the first time—maintained a fully functional lung outside the body for several days. They designed the cross-circulation platform that maintained the viability and function of the donor lung and the stability of the recipient over 36-56 hours, used the advanced support system to fully recover the functionality of lungs injured by ischemia and made them suitable for transplant. (Nature Biomedical Engineering 3/6)

Medicine

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Cornea, eye, Blindness, Vision Loss, Stem Cell

Stem Cell Treatment May Restore Vision to Patients with Damaged Corneas

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Researchers have developed a new way to identify and sort stem cells that may one day allow clinicians to restore vision to people with damaged corneas using the patient’s own eye tissue.

Medicine

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Bone Marrow, Hematopoietic Stem Cells, Aging, Elderly, immune system cells, Cancer, Blood Cancers, Leukemia, Research, Experimental Treatment, EMBO, Cincinnati Children's Hospital Medical Center, press release, news, Media

Scientists Wage Fight Against Aging Bone Marrow Stem Cell Niche

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As people get older so do the hematopoietic stem cells (HSCs) that form their blood, creating an increased risk for compromised immunity and certain blood cancers. Now researchers are reporting in the scientific journal EMBO that the bone marrow niche where HSC’s form also ages, contributing to the problem. In a study published March 2, scientists in Germany and the United States propose rejuvenating the bone marrow niche where HSCs are created.

Medicine

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cancer stem cell, Acute Myeloid Leukemia, Acute Lymphocytic Leukemia (All), Daunorubicin, Chemotherapy

Getting to the Root of the Problem by Targeting Cancer Stem Cells

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A research team comprised of members from The University of Kansas Cancer Center, Stowers Institute for Medical Research, and Children’s Mercy are looking at ways to target cancer stem cells to ensure that once a cancer patient goes into remission, they are not at risk of their cancer returning.

Medicine

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Stem Cells, regenerative biology, development and reproductive biology, Developmental Biology

Study Shows Stem Cells Fiercely Abide by Innate Developmental Timing

The regenerative biology team at the Morgridge Institute for Research, led by stem cell pioneer and University of Wisconsin-Madison Professor James Thomson, is studying whether stem cell differentiation rates can be accelerated in the lab and made available to patients faster.

Science

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Stem Cells, Stem Cell Therapy, Health, Science, Biomedical Engineering, Engineering, DNA, genetic, Cancer, Bone Marrow Transplant, cell, Cells, Epigenetic, super-resolution microscopy, genes, EDICTS, Tissue Engineering, Regenerative Medicine, National Institute of Biomedical Imaging and Bioengineering , Imaging, Rutgers, Rutgers University, New Jersey, NJ

Super Resolution Imaging Helps Determine a Stem Cell’s Future

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Scientists at Rutgers and other universities have created a new way to identify the state and fate of stem cells earlier than previously possible. Understanding a stem cell’s fate – the type of cell it will eventually become – and how far along it is in the process of development can help scientists better manipulate cells for stem cell therapy.

Medicine

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Cancer, Stem Cell Transplant, CMV, Francis Eppes Professor, Dana Farber Cancer Institute, Cytomegalovirus

New Antiviral Drug Cuts Cytomegalovirus Infection and Improves Survival in Patients Undergoing Donor Stem Cell Transplant

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In a significant advance in improving the safety of donor stem cell transplants, a major clinical trial led by researchers at Dana-Farber Cancer Institute has shown that a novel agent can protect against the most common viral infection that patients face after transplantation.

Medicine

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Sanford Researchers Take Broad Look at Stem Cells

Sanford Research scientists recently published a review article in an issue of Stem Cells Translational Medicine focused on the study of and utility of adult-derived stem cells.

Medicine

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Kimmel Cancer Center, Gregg Semenza, Cancer, Chemotherapy

Scientists Identify Chain Reaction That Shields Breast Cancer Stem Cells From Chemotherapy

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Working with human breast cancer cells and mice, researchers at Johns Hopkins say they have identified a biochemical pathway that triggers the regrowth of breast cancer stem cells after chemotherapy.

Medicine

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Hearing Loss, Stem Cell Therapy, Regeneration Of Hair Cells, Deafness

New Technique Generates High Volume of Sensory Cells Needed for Hearing

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In 2013, Mass. Eye and Ear researchers restored partial hearing to mice by regenerating hair cells — tiny, sound-sensing cells in the ear, which are lost through noise damage, age, etc., and do not regenerate on their own — by converting stem cells found in the ear into hair cells. However, the success of restoring hearing through this approach was limited by the small number of cells that could be turned into hair cells. In a new study in Cell Reports, a research team from Mass. Eye and Ear, Brigham and Women's Hospital and MIT has shown that they can augment the number of those cells, and then convert that large population into hair cells, lending hope that full hearing can be restored to those with hearing loss due to damaged hair cells.







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