Washington, DC (January 8, 2020) — The House Energy and Commerce Committee is scheduled to hold a hearing on Wednesday, January 8, on the Comprehensive Immunosuppressive Drug Coverage for Kidney Transplant Patients Act of 2019, advancing a long-standing legislative priority of the American Society of Nephrology.
UT Southwestern researchers find that humans and mice with pancreatitis are deficient in a stress hormone called FGF21.
Study shows Colorado drug SVC112 stops production of proteins that cancer stem cells need to survive and grow
In addition to research exploring such areas as biomarkers, nano- and neurotoxicology, and developmental and reproductive toxicology, the January 2020 issue of Toxicological Sciences features a new article category, ToxPoint, to underscore cutting-edge topics in toxicology.
In the largest genetic study on anxiety to date, VA researchers found new evidence on the underlying biological causes of the disorder.
Of three possible ways for people to deliver the life-saving antidote naloxone to a person experiencing an opioid overdose, the use of a nasal spray was the quickest and easiest according to research conducted by William Eggleston, clinical assistant professor at Binghamton University, State University of New York, and colleagues at SUNY Upstate Medical University.
A risk-management program set up in 2012 by the U.S. Food and Drug Administration to curb improper prescribing of extended-release and long-acting opioids may not have been effective because of shortcomings in the program’s design and execution, according to a paper from researchers at the Johns Hopkins Bloomberg School of Public Health.
Eric Prossnitz, PhD, and his team have recently completed studies on a compound that they think could be made to attack breast cancer cells differently than current drugs. Their work is reported in the November online issue of Cell Chemical Biology. This newly discovered behavior could turn the chemical into potent breast cancer drugs
ISPOR—the professional society for health economics and outcomes research (HEOR), announced the publication of its 2020 Top 10 HEOR Trends report. In the report, the Society has identified the top 10 HEOR trends that will shape the field and influence healthcare over 2020 and the near future.
Children with public insurance are slightly more likely to receive medical services that they don’t need than those with private insurance, a new study finds.
With the recent legalization of cannabis edibles in Canada, physicians and the public must be aware of the novel risks of cannabis edibles
Researchers have developed a way to prop up a struggling immune system to enable its fight against sepsis, a deadly condition resulting from the body’s extreme reaction to infection.
Ein Studie von Mayo Clinic an 5540 Patienten mit metastasiertem kolorektalem Karzinom hat ergeben, dass für Patienten, deren Krankheit unter Kontrolle ist, eine Erhaltungs-Chemotherapie nach der Erstbehandlung nützlicher als eine aggressivere Behandlung ist.
项在5,540名转移性结直肠癌患者中进行的Mayo Clinic研究发现，对于病情得到控制的患者而言，在初始治疗后进行维持化疗比激进治疗更有益。
Une étude de Mayo Clinic portant sur 5 540 patients atteints d'un cancer colorectal métastatique révèle que la chimiothérapie d’entretien réalisée après le traitement initial est plus bénéfique pour les patients dont la maladie est sous contrôle, par rapport à un traitement plus agressif.
Um estudo da Mayo Clinic que envolveu 5.540 pacientes com câncer colorretal metastático revelou que a quimioterapia de manutenção após o tratamento inicial é mais benéfica para pacientes cuja doença está sob controle, em contraste com um tratamento mais agressivo.
اكتشفت دراسة أجرتها Mayo Clinic شملت 5540 مريضًا من مرضى سرطان القولون والمستقيم النقيلي أن تلقي علاج المداومة الكيميائي بعد المعالجة الأولية كان أكثر فائدة للمرضى الذين يعانون من مرض يمكن السيطرة عليه، مقارنةً بالمزيد من العلاج المكثف
SLAS Discovery, one of two official journals of the Society for Laboratory Automation and Screening focused on developing chemical and biological tools and novel assay methods to help advance drug discovery, announced a new tagline for 2020 and beyond. “Advancing the Science of Drug Discovery” will replace “Advancing Life Sciences R&D,” as the official tagline beginning with the just-released January edition of the publication.
ROCHESTER, Minnesota: El costo de los tipos de insulina más frecuentemente usados es en Estados Unidos 10 veces mayor que en el resto de países del mundo desarrollado, expone un comentario en Mayo Clinic Proceedings. Este costo prohibitivo es la causa para que algunos pacientes estadounidenses con diabetes tipo 1 racionen la cantidad de insulina que se administran y, consecuentemente, afronten implicaciones de vida o muerte.
A first-of-its-kind study on molecular interactions by biomedical engineers in the University of Minnesota’s College of Science and Engineering will make it easier and more efficient for scientists to develop new medicines and other therapies for diseases such as cancer, HIV, and autoimmune diseases. The study resulted in a mathematical framework that researchers plan to use to develop a web-based app that other researchers can use to speed the development of new therapies for diseases.
The most commonly used forms of insulin cost 10 times more in the U.S. than in any other developed country, according to a commentary in Mayo Clinic Proceedings. This prohibitive cost is causing some U.S. patients with Type 1 diabetes to ration the amount of insulin they use, with life-threatening implications.
Researchers report cases of five epilepsy patients who found better treatments for deleterious neuropsychiatric symptoms like anxiety and depression using data collected — while the patients were at home — from implanted neurostimulators placed in their brains to control their epileptic seizures.
Glycans on antibody drugs can significantly affect their safety and efficacy. A study conducted by NIST investigates how well pharmaceutical and research labs are equipped to measure this important post-translational modification.
Bacteria are becoming increasingly resistant to antibiotics. A major cause is their overuse in both humans and animals. At the same time, a lack of financial incentives is setting back efforts to discover new classes of antibiotics. The problem is both global and local, and without new initiatives, many common medical conditions could become deadly once again.
The review has collected studies concerning the anticancer potential of curcumin against the most widespread cancers and also describing the molecular mechanisms of action.
Earlier today, a release was issued stating that antibiotic maker Melinta is closing. This information was incorrect. Melinta has filed for Chapter 11 bankruptcy but intends to remain open and is in the process of restructuring. The bankruptcy filing announced today by antibiotic maker Melinta once again highlights the daunting challenges facing research and development of new infection-fighting drugs.
During the past years, artificial intelligence (AI) -- the capability of a machine to mimic human behavior -- has become a key player in high-techs like drug development projects.
New direct-acting antiviral (DAA) medications are highly effective in curing patients with hepatitis C virus (HCV). But these drugs carry a risk of interactions with antiretroviral therapy (ART) used to control HIV. An update on management of drug interactions in patients coinfected with HIV/HCV is presented in The Journal of the Association of Nurses in AIDS Care (JANAC). The official journal of the Association of Nurses in AIDS Care, JANAC is published in the Lippincott portfolio by Wolters Kluwer.
Lab-grown brain organoids developed from a patient’s own glioblastoma, the most aggressive and common form of brain cancer, may hold the answers on how to best treat it. A new study in Cell from researchers at Penn Medicine showed how glioblastoma organoids could serve as effective models to rapidly test personalized treatment strategies.
Scientists at St. Jude Children’s Research Hospital have discovered a new way that the molecule RIPK1 leads to cell death in infected, damaged or unwanted cells showing that more than one mechanism can trigger the process. The findings appeared online today in the Journal of Experimental Medicine.
From nanoparticles to algae ecology, the Office of Science supported a variety of research in 2019.
This edition of Science Snapshots highlights the discovery of an investigational cancer drug that targets tumors caused by mutations in the KRAS gene, the development of a new library of artificial proteins that could accelerate the design of new materials, and new insight into the natural toughening mechanism behind adult tooth enamel.
Pregnant women living with HIV don’t always receive antiretroviral medications recommended for use in pregnancy, according to a recent study published in Jama Network Open this week. Ann & Robert H. Lurie Children's Hospital of Chicago’s researchers collaborated in the multi-site Surveillance Monitoring for ART Toxicities (SMARTT) study of the Pediatric HIV/AIDS Cohort Study (PHACS) network.
Researchers from Cornell University and the University of Wageningen used a social psychology approach to understand how dairy farmers’ views impact how and when they use antibiotics to treat their cows.
Researcher Daniela Salvemini, Ph.D., professor of pharmacology and physiology at Saint Louis University, has been named a Fellow of the National Academy of Inventors (NAI) for her contributions toward understanding and finding better treatments for pain.
One of the challenges in using machine learning for drug development is to create a process for the computer to extract needed information from a pool of data points. Drug scientists must pull biological data and train the software to understand how a typical human body will interact with the combinations that come together to form a medication.
The proportion of high-strength painkiller poisonings among children which result in emergency hospital admissions has increased, according to research published in the peer-reviewed journal Clinical Toxicology.
Tiny solutions are being sought for big liver problems by a scientist at McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth).
GB Sciences, Inc. (OTCQB: GBLX) announced significant preclinical results for their Parkinson's disease ("PD") formulations from the midterm report for their preclinical study being performed by Dr. Lee Ellis of the National Research Council (NRC) in Halifax, Nova Scotia, CANADA.
Heart cells have tiny pores that generate electrical signals to initiate each heart beat. Structural studies of these channels are providing details how they work, how they malfunction due to different inherited mutations, and how they respond to drugs.
A new study that sought to find out whether serotonin reuptake inhibitors or trauma-focused psychotherapy is more effective in treating posttraumatic stress disorder (PTSD) concluded there is insufficient evidence at present to make that determination.
Drawing inspiration from nature, University of Wisconsin–Madison chemists have discovered an efficient way to wrangle long, snaking molecules to form large rings — rings that form the backbone of many pharmaceuticals but are difficult to produce in the lab.
Pharmaceutical R&D executive, accomplished scientist to lead School’s efforts to propel basic science discoveries into treatments
A Wistar study demonstrated that NAMPT, an enzyme critical for NAD+ biosynthesis, mediates selection of stem-like chemoresistant cells following cisplatin treatment.
A new study finds that a medication commonly prescribed to prevent and combat symptoms of acute mountain sickness does not reduce exercise performance at high altitudes. This may be especially important for military personnel and first responders not accustomed to working above sea level. The study is published ahead of print in the Journal of Applied Physiology.
The U.S. Food & Drug Administration (FDA) granted accelerated approval to the drug enfortumab vedotin (EV) to treat adult patients with advanced urothelial or bladder cancer.
Announcement of the 2020 class of Harrington Scholar-Innovators from the Harrington Discovery Institute at University Hospitals in Cleveland, Ohio, Class includes the institute’s first Canadian scholar. The grants support a range of drug discovery projects including novel therapies for treating Alzheimer’s, Prion disease, cancer, lung diseases, resistant tuberculosis, and rare genetic disorders.
Researchers at Children’s Medical Center Research Institute at UT Southwestern (CRI) have uncovered why certain melanoma cells are more likely to spread through the body.
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