Opioid use in Mexico has been low, but national and international factors are converging and a threat of increased drug and addiction rates exists. Many of these factors may have originated in the U.S., making this a potential joint U.S.-Mexico epidemic.
Researchers have generated six Zika virus antibodies that could be used to test for and possibly treat a mosquito-borne disease that has infected more than 1.5 million people worldwide, according to a study published in PLOS ONE.
A new option – a combination of a standard drug and the novel agent venetoclax – has been granted accelerated approval by the Food and Drug Administration for certain AML patients after a large, multicenter phase 1 clinical trial showed the combination had “promising efficacy” and was well tolerated in older AML patients.
A innovative agent that has been used for decades to treat alcohol-use disorder is showing real promise for the treatment of stroke and has resulted in a U.S. patent application for a neuroscientist at FAU. The researcher has also filed a patent application for a novel gene therapy for stroke and Alzheimer’s disease.
The Coriell Institute for Medical Research, Cooper University Health Care and Cooper Medical School of Rowan University (CMSRU) are launching the Camden Opioid Research Initiative (CORI), a first-of-its-kind undertaking to investigate the genetic and biological factors that contribute to the development of opioid use disorder (also referred to as opioid dependence or addiction). Opioid overdoses continue to climb in New Jersey and nationally and the opioid addiction epidemic is one of the most urgent public health concerns of our time. This year is the deadliest year of this epidemic in the Garden State.
The U.S. Food and Drug Administration (FDA) has approved the first ever inhibitor drug specifically approved for treating patients with relapsed or refractory acute myeloid leukemia (AML) with a mutation in the Fms-like tyrosine kinase 3 (FLT3) gene.
Black patients with atrial fibrillation are significantly less likely to receive oral anticoagulants--particularly newer, more effective versions-- than white and Hispanic patients.
Latest Cancer Research Institute update on the landscape of anti-PD1/L1 checkpoint inhibitor clinical trials
Clinical Studies in Patients using IB1000s with Lewy Body Dementia and Fronto-Temporal Dementia Showed Marked Improvement in Quality of Life, Cognition, Mobility, Speech, and a Disease-Modifying Effect
A study demonstrates the feasibility of using a steady-state/lifetime fluorescence plate reader for direct optimization of challenging formulation conditions and highlights the importance of performing formulation optimization under commercially relevant conditions.
Mayo Clinic’s Nuclear Medicine Division on Mayo Clinic's Arizona, Florida and Minnesota campuses significantly increased services provided to clinical and research patients in 2018. The division debuted a new therapeutic-diagnostic, or “thera-nostic,” practice, joined major research trials, and advanced radiotracer production capabilities.
Nerve cells stripped of their insulation can no longer carry vital information, leading to the numbness, weakness and vision problems often associated with multiple sclerosis. A new study shows an overlooked source may be able to replace that lost insulation and provide a new way to treat diseases like MS.
The American Board of Anesthesiology (ABA) and the Foundation for Anesthesia Education and Research (FAER) are co-sponsoring a FAER/ABA Research in Education Grant to advance the careers and knowledge of anesthesiologists interested in the key elements of education in anesthesiology—curriculum, instruction and assessment.
Experts will meet to discuss the latest discoveries in drugs and how best to use existing ones as effectively and safely as possible, at an international conference in Adelaide this week (27-30 November).
A coalition of healthcare groups today issued a series of wide-ranging recommendations to address the ongoing shortages of critical medications affecting patient care across the country. The American Hospital Association (AHA), American Society of Anesthesiologists (ASA), the American Society of Clinical Oncology (ASCO), ASHP (American Society of Health-System Pharmacists), and the Institute for Safe Medication Practices (ISMP) released the proposals, which provide suggestions for regulatory, legislative, and marketplace solutions to stem drug shortages, in advance of tomorrow’s public meeting hosted by the U.S. Food and Drug Administration (FDA) and the Duke Margolis Center for Public Health Policy.
A machine learning system developed at the Technion enables estimation of the relevance of lab mice studies to human physiology. The tool is expected to speed up the development of new medical therapies.
The GW School of Medicine and Health Sciences and La Clinica del Pueblo have partnered to launch Project ECHO in Washington, D.C. to increase workforce capacity to provide best practice specialty care and reduce health disparities.
UT Southwestern researchers have found that an enzyme on the surface of some lung cancer cells helps feed the cancer, making it a tempting treatment target.
A DNA vaccine tested in mice reduces accumulation of both types of toxic proteins associated with Alzheimer’s disease, according to research that scientists say may pave the way to a clinical trial.
The Graduate School of Biomedical Sciences at the Icahn School of Medicine at Mount Sinai is pleased to announce a new Master of Biomedical Data Science (MSBDS) degree. Applications are open now through June 2019 for enrollment in the fall of 2019.
The Foundation for Anesthesia Education and Research (FAER) announced today that it was presented with three 2018 Solutions Day Awards from .orgCommunity. On Thursday, FAER received the Innovation Award for its “Swimming with Sharks” program and the Celebrating Associations Award for its “Honor Your Mentor” campaign. In addition, Rupa Brosseau, director of FAER, was presented with the Outstanding Nonprofit Leader Award.
West Virginia University chemists have developed an experiment to improve the efficiency of creating new medicine.
A new study designed to reach hospitalized patients at risk shows that a “real-time” educational conversation, video or leaflet can lower the missed dose rates of drugs that can prevent potentially lethal blood clots in their veins.
Anti-malaria drugs known as chloroquines have been repurposed to treat cancer for decades, but until now no one knew exactly what the chloroquines were targeting when they attack a tumor. Now, researchers from the Abramson Cancer Center of the University of Pennsylvania say they have identified that target – an enzyme called PPT1.
SBP today announced that the first healthy subject has been dosed in a Phase 1 clinical trial evaluating an inflammation-inhibiting biologic that arose from a research collaboration between Eli Lilly and Company (Lilly) and SBP formed in 2015.
Adding steroids to local anesthetic increases the success rate of short-term but not long-term relief of chronic non-cancer pain.
A minimal opiate supply, just a two-day course compared to a traditional two-week prescription, along with a scheduled-dose multimodal pain regimen after surgery limits the use of opiate medication by patients and, subsequently, opiate-related adverse effects while still providing effective pain control and high patient satisfaction.
Researchers in the Department of Physiology & Biophysics at the University of California, Irvine School of Medicine have discovered the molecular basis for therapeutic actions of an African folk medicine used to treat a variety of illnesses and disorders including diabetes, pain, headaches, paralysis and epilepsy.
Two UT Southwestern faculty members have been selected to receive 2019 Edith and Peter O’Donnell Awards from The Academy of Medicine, Engineering and Science of Texas (TAMEST).
44 percent of people who died from fentanyl overdose had previously been prescribed fentanyl by a medical professional, and 37 percent of those people had a prescription for fentanyl within 60 days of their death.
A Phase I/II study, led by investigators at The University of Texas MD Anderson Cancer Center, reports an investigational drug called tagraxofusp has demonstrated high response rates in patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN), a rare but highly aggressive – and often fatal bone marrow and blood disorder – for which there are no existing approved therapies.
IU scientists have found that drug-delivering nanoparticles attach to their targets differently based upon their position in time. The discovery could improve methods for screening drugs for therapeutic effectiveness.
A session at ISPOR Europe 2018 explored the issue of valuing a cure in healthcare.
The second plenary at ISPOR Europe 2018, “Pharmaceutical Pricing: The Many Faces of Fairness,” sought to define “fair” in the context of pharmaceutical pricing.
Mayo Clinic has announced a gift of $200 million from Jay Alix, noted philanthropist of Birmingham, Mich. and founder of the firm, AlixPartners. The endowment gift, the largest ever to the Mayo Clinic, is designated to Mayo Clinic School of Medicine. It recognizes the importance of educating the next generation of physicians who will carry on Mayo’s tradition of solving the most serious and complex medical challenges – one patient at a time.
In an international collaboration between Sementis and Enesi Pharma, experts in the field of Zika virus and chikungunya vaccine research at UniSA’s Experimental Therapeutics Laboratory are working to evaluate a needle-free vaccination technology for SCV-based vaccines.
New team-based care guided by a personalized risk score for heart failure patients reduced the mortality rate of high-risk heart failure patients by nearly 50 percent, according to new research from the Intermountain Medical Center Heart Institute in Salt Lake City.
Only a tiny fraction of patients hospitalized for COPD, or chronic obstructive pulmonary disease, participate in a pulmonary rehabilitation program following hospitalization, even though such programs are recommended and Medicare covers their cost, according to new research published online in the Annals of the American Thoracic Society.
BUFFALO, N.Y. – The Medicaid expansions that voters in Idaho, Nebraska and Utah passed this week, after their own state legislatures rejected them, didn’t surprise Nancy H. Nielsen, MD, PhD, senior associate dean for health policy at the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, and former head of the American Medical Association.
Rising rates and doses of prescription opioids may be a warning sign of an increased risk of death – even for patients not recognized as having opioid use disorder (OUD), reports a study in the Journal of Addiction Medicine, the official journal of the American Society of Addiction Medicine (ASAM). The journal is published in the Lippincott portfolio by Wolters Kluwer.
SAN FRANCISCO – Preliminary data from a new study presented this week at The Liver Meeting® – held by the American Association for the Study of Liver Diseases – found that people who inject drugs who are infected with the hepatitis C virus have high rates of hepatitis C treatment adherence (completion of their treatment), and sustained virologic response. Based on these findings, researchers conclude these patients should be included in HCV treatment programs.
SAN FRANCISCO – Preliminary data from a new study presented this week at The Liver Meeting® – held by the American Association for the Study of Liver Diseases – found that patients treated with immune checkpoint inhibitors rarely develop severe liver toxicity, but the majority of those who do permanently stop this cancer treatment. None of the patients developed liver failure as a result of this treatment.
SAN FRANCISCO – Data from a new study presented this week at The Liver Meeting® – held by the American Association for the Study of Liver Diseases – found the combination of glecaprevir and pibrentasvir is highly effective and well tolerated in patients with chronic hepatitis C virus (commonly called HCV) genotype-1 infections who have prior treatment experience with sofosbuvir/NS5A inhibitor.
In a study published today in the journal Cell, University of California, Irvine researchers reported that they have accelerated and simplified directed evolution by having live cells do most of the heavy lifting. By inserting a specially engineered DNA replication system into yeast, the scientists were able to coax selected genes to rapidly and stably mutate and evolve as the host yeast cells reproduced.
A large-scale soil project uncovered genetic information from bacteria with the capacity to make specialized molecules that could lead to new pharmaceuticals.
Loyola Medicine has announced that Shawn P. Vincent is the new president & chief executive officer of the regional system. He also is a member of the Loyola Medicine board of directors.
Researchers with the Department of Energy’s Oak Ridge National Laboratory have discovered that communities of microbes living near tree roots are ten times more diverse than the human microbiome and produce a cornucopia of novel molecules that could be useful as antibiotics and anti-cancer drugs.
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