Different fates of neural stem/progenitor cells (NSPCs) and their progeny are determined by the gene regulatory network, where a chromatin-remodeling complex affects synergy with other regulators. Here, we review recent research progress in
Acute respiratory distress syndrome (ARDS) is a common and clinically devastating disease that causes respiratory failure. Morbidity and mortality of patients in intensive care units are stubbornly high, and various complications severely a
Mesenchymal stromal/stem cells (MSCs) are currently applied in regenerative medicine and tissue engineering. Numerous clinical studies have indicated that MSCs from different tissue sources can provide therapeutic benefits for patients. MSC
BACKGROUNDThere is no established treatment to impede the progression or restore kidney function in human chronic kidney disease (CKD). AIMTo examine the efficacy of cultured human CD34+ cells with enhanced proliferating potential in kidne
BACKGROUNDFibroblast plays a major role in tendon-bone healing. Exosomes derived from bone marrow mesenchymal stem cells (BMSCs) can activate fibroblasts and promote tendon-bone healing via the contained microRNAs (miRNAs). However, the und
Cancer stem cells (CSCs) are the main cause of tumor growth, invasion, metastasis and recurrence. Recently, CSCs have been extensively studied to identify CSC-specific surface markers as well as signaling pathways that play key roles in CSC
Osteoarthritis (OA) is the most common musculoskeletal disease, and it is a major cause of pain, disability and health burden. Pain is the most common and bothersome presentation of OA, but its treatment is still suboptimal, due to the shor
A century has passed since the Nobel Prize winning discovery of insulin, which still remains the mainstay treatment for type 1 diabetes mellitus (T1DM) to this day. True to the words of its discoverer Sir Frederick Banting, “insulin is no
Cell transplantation therapy has certain limitations including immune rejection and limited cell viability, which seriously hinder the transformation of stem cell-based tissue regeneration into clinical practice. Extracellular vesicles (EVs
Since dental pulp stem cells (DPSCs) were first reported, six types of dental SCs (DSCs) have been isolated and identified. DSCs originating from the craniofacial neural crest exhibit dental-like tissue differentiation potential and neuro-e
Obesity, the global pandemic since industrialization, is the number one lifestyle-related risk factor for premature death, which increases the incidence and mortality of various diseases and conditions, including cancer. In recent years, th
Mayo Clinic ha logrado avances importantes en la biofabricación de productos terapéuticos en etapa inicial. La atención se centra en medicamentos nuevos derivados del cuerpo humano, llamados productos bioterapéuticos, que están dando forma al futuro de la medicina.
قطعت مايو كلينك خطوات كبيرة في مجال التصنيع الحيوي للعلاجات في مراحلها المبكرة. وينصب التركيز في هذا المجال على أدوية جديدة مشتقة من جسم الإنسان، تسمى العلاجات الحيوية، والتي ستشكّل مستقبل الأدوية.
A Mayo Clinic fez avanços significativos na biomanufatura de produtos terapêuticos de estágio inicial. O foco está em novos medicamentos derivados do organismo humano, chamados de produtos bioterapêuticos, que estão definindo o futuro da medicina.
Creating accessible, affordable equipment to democratize research is the foundation of frugal science. Now, with a new five-year grant from the National Institutes of Health (NIH), Bhamla and Standeven will pave the way to bring frugal science to high schools across Georgia.
As part of its “Moon to Mars” initiative, NASA plans to send humans farther into space than ever before.
Scientists demonstrated that human 14-3-3 proteins, that are known for their role in replication of many viruses, bind differentially with more often mutating regulatory part of nucleoprotein (N protein) of coronavirus SARS-CoV-2.
Researcher will discuss the study which involved a sleeping aid known as suvorexant that is already approved by the Food and Drug Administration (FDA) for insomnia, hints at the potential of sleep medications to slow or stop the progression of Alzheimer’s disease.
Scientists have long been intrigued by the remarkable properties of spider silk, which is stronger than steel yet incredibly lightweight and flexible. Now engineers have made a significant breakthrough in the fabrication of synthetic spider silk, paving the way for a new era of sustainable clothing production.
Imagine by only attaching a number of electromyography (EMG) sensors to your legs, your motion in the future several seconds can be predicted. Such a way of predicting motion via muscle states is an alternative to the mainstream visual cue-based motion prediction, which heavily relies on multi-view cameras to construct time-series posture. However, there is still a gap between muscle states and future movements.
An essential pillar of Earth’s ecological system, fungi have long been used to better the lives of humans. While these organisms are still vastly understudied, a new review paper suggests that their unique genomes could be used to make progress in the biotech industry.
The proposed material is chemically similar to mammalian proteins and is non-toxic, therefore contributing to fast adherence and division of human stem cell cultures. This development will help accelerate cell culture growth, which are used in medicine as a replacement for damaged tissue.
Air pollution and its high concentration in cities is one of the problems facing society today, due to its harmful effects on the environment, but also on human health. One of the causes of this pollution is the increase in nitrogen oxide emissions, mainly due to the use of fossil fuels.
A group of researchers at the State University of Campinas (UNICAMP) in Brazil have grown microalgae under controlled conditions in a laboratory in order to use their metabolites, especially lipids, with the prime purpose of producing biofuel.
Scientists in Melbourne have designed a new type of oral capsule that could mean pain-free delivery of insulin and other protein drugs.
University of Pittsburgh researchers developed a novel approach that promoted bone regeneration in mice without implantation of bone tissue or biomaterials.
Hackensack Meridian Health, the state’s largest and most comprehensive health network, is partnering with Etta.io., a Denver-based healthcare technology startup that builds Artificial Intelligence (AI) applications to detect tumors difficult to see with the naked eye, even for specialists.
Today, foldable phones are ubiquitous. Now, using models that predict how well a flexible electronic device will conform to spherical surfaces, University of Wisconsin–Madison and University of Texas at Austin engineers could usher in a new era in which these bendy devices can integrate seamlessly with parts of the human body.
Roots of a traditional medicine plant called the orange climber can fluoresce an ethereal blue hue under ultraviolet (UV) light. And now, researchers in ACS Central Science have identified two coumarin molecules that could be responsible, one of the which could someday be used for medical imaging.
Cedars-Sinai Cancer’s commitment to convergent science—the deep melding of computational, physical engineering and biological sciences—is evident throughout its 2023 Annual Report.
Details of the mechanisms at the cellular level remain hidden from view. Now, special reporter proteins developed by a research team led by the Technical University of Munich (TUM) may help unveil these mechanisms.
Cedars-Sinai investigators, in collaboration with Axiom Space of Houston, are sending stem cells to space in early May to explore whether microgravity can make it easier and more efficient to produce large batches of stem cells.
Researchers have made huge strides in ensuring that red blood cell substitutes – or artificial blood – are able to work safely and effectively when transfused into the bloodstream.
Scientists at St. Jude Children’s Research Hospital and the Broad Institute of MIT and Harvard showed how prime editing can correct mutations that cause sickle cell disease in a potentially curative approach.
Dr. Song Soo-chang's research team at the Center for Biomaterials, Korea Institute of Science and Technology (KIST, President Yoon Seok-jin), revealed the first development of poly(organophosphazene) hydrogel-based temperature-sensitive bioink that stably maintained its physical structure only by temperature control without photocuring, induced tissue regeneration, and then biodegraded in the body after a certain period of time.
New AI tool accurately predicts both overall survival and disease-free survival after colorectal cancer diagnosis. The model uses visual markers on pathology images to glean insights into a tumor’s genomic profile and predicts tumor behavior, disease progression, treatment response. The new model could help augment clinical decision-making. Because the AI tool relies on images alone, it could be particularly valuable for hospitals lacking the technology or expertise to perform sophisticated genomic profiling of tumor tissues.
Mayo Clinic has made significant strides biomanufacturing early-stage therapeutics. The focus is on new medicines derived from the human body, called biotherapeutics, which are shaping the future of medicine.
Accure Acne, Inc.™ (www.accureacne.com), a pioneer in the development of innovative solutions for the treatment of acne, announced today that Alfred (Al) Intintoli has joined the company as Chief Technology Officer.
Alamar Biosciences, a company powering precision proteomics to enable the earliest detection of disease, announced today the unveiling of its technology platform NULISA™, a novel automated ultrasensitive and highly multiplexed proteomics technology for liquid biopsy.
A new twist on a drug used to treat alcohol use disorder could double up as a treatment for stroke. Called “Carb” for short, this new formulation is designed to treat ischemic stroke, protect brain tissue against injury and minimize the size of a brain infarct.
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Some polymers can expand and contract — acting like artificial muscles — but only when stimulated by high voltages. Researchers in ACS Applied Materials & Interfaces report a series of thin, elastic films that respond to lower electrical charges, representing a step toward artificial muscles.
Wireless or leadless pacemakers, commonly implanted in adults, may be a safe and effective short-term option for children with slow heartbeats, according to new research published today in Circulation: Arrhythmia and Electrophysiology, a peer-reviewed journal of the American Heart Association.
Global pharmaceutical company Takeda has agreed to exclusively license a group of small molecules that target tau – a protein in which misfolding and aggregation are believed to be a cause of Alzheimer’s disease.
An implantable device that stimulates the vagus nerve, paired with traditional rehabilitation therapy, is being used to restore hand and arm function in stroke survivors treated in New Jersey.
A team of scientists from the Universities of Sheffield, Reading and University College London (UCL) and US-based biopharmaceutical company Neuresta have created a new, elongated botulinum neurotoxin which can alleviate chronic pain without risk of paralysis or addiction.
Imagine if you could ask a machine to “smell” something for you with just a click of a button. That’s what electronic noses, or e-noses, are for. They are systems that combine chemical gas sensors, signal processing and machine learning algorithms to mimic the sense of smell.
Did you know recycled human hair has many industry uses? As you might expect, beauty trends have fueled growth in the global hair business. But could those clippings — the ones often found on the floor of a hair salon — help repair dilapidated bridges and buildings across Kentucky and beyond? A research team in the College of Engineering at the University of Kentucky is leading the charge to answer that very question.
Ribonucleic acid (RNA) molecules are present in all living cells, with different types of RNA having different jobs. For example, messenger RNA is copied from DNA and carries instructions on how to make a protein. Transfer RNA (tRNA) links the mRNA sequence with its corresponding amino acid, ensuring that proteins are stitched together correctly as instructed by DNA.
Zhang et al. show that the mechanical properties of a three-dimensional (3D) hydrogel can enhance the secretion of niche factors from bone marrow stromal cells, which in turn promotes the maintenance of hematopoietic stem cells (HSCs) and reverses a
Li et al. report on the generation of cynomolgus monkey models of blastocyst-stage embryos (called “blastoids”) using naive cynomolgus embryonic stem cells. These blastoids recapitulate gastrulation in vitro and induce early pregnancy responses
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