Feature Channels: Personalized Medicine

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In the wake of the novel coronavirus pandemic, the need for reliable, accurate, and accessible laboratory testing is more evident than ever before. At the 2020 AACC Annual Scientific Meeting & Clinical Lab Expo, laboratory medicine experts will present the cutting-edge research and technology that is revolutionizing clinical testing and patient care for COVID-19 and across the spectrum of healthcare.

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Bernard Thurman was referred to a personalized cancer therapy trial at Moores Cancer Center at UC San Diego Health, a collaboration with the La Jolla Institute for Immunology, the trial employs a patient’s immune cells — specifically tumor infiltrating lymphocytes (TIL) — to destroy cancer cells.

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Henry Ford Health System today announced a $16 million gift to its Henry Ford Pancreatic Cancer Center (HFPCC), which was launched in 2018 by an initial $20 million gift from the same donor, who wishes to remain anonymous. The gift will bolster the HFPCC’s clinical and translational research endeavors in the fight against this devastating disease, for which the five-year survival rate is only 9 percent.

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A new biomarker discovered by a team that includes researchers from Penn Medicine identifies patients with an aggressive form of lymphoma unlikely to respond to the targeted treatment ibrutinib.

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High-resolution mass spectrometry promotes new methods for analysis. Humans are exposed to various environmental or dietary molecules that can attenuate or even increase the effect of therapeutic drugs. Studies on the industrial chemical bisphenol A and the phytoestrogen genistein, for example, have shown drug-exposome interactions.

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Coriell Life Sciences, a trusted and innovative precision medicine organization, is honored to accept two industry awards: EHIR's Fall 2020 Traction Award Healthcare Tech Outlook's Top Precision Medicine Providers in Europe

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SEATTLE — Nov. 18, 2020 — Fred Hutchinson Cancer Research Center’s latest findings on cell therapies, repairing immune function, and more will be featured at the 62nd American Society of Hematology Annual Meeting & Exposition, to be held virtually Dec. 5 – 8.Dr. Stephanie Lee, ASH president and Fred Hutch physician-scientist will kick off the meeting with a fireside chat with Dr.

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A new analysis highlights the diversity of immune response in pancreatic cancer, and points toward the need for treatments tailored to individual patients.

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UC San Diego researchers use experimental artificial intelligence system called DrugCell to predict the best approach to treating cancer.

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A study led by researchers at IUPUI and Indiana University Bloomington is the first to describe a biochemical mechanism that influences activity in a protein linked to cancer, aging, inflammatory responses and addiction-related behaviors.

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Brendan G. Carr, MD, MA, MS, and Judy H. Cho, MD, of the Icahn School of Medicine at Mount Sinai, have been elected to the National Academy of Medicine (NAM).

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Rutgers researchers have discovered human gene markers that work together to cause metastatic prostate cancer – cancer that spreads beyond the prostate.

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A multidisciplinary team from Columbia Engineering, Columbia’s College of Dental Medicine and Department of Medicine, Louisiana State University, LaCell LLC, and Obatala Sciences has now bioengineered living cartilage-bone temporomandibular joint grafts, precisely matched to the recipient, both biologically and anatomically. Their new study, published today in Science Translational Medicine, builds upon a long series of their previous work on bioengineering functional cartilage and bone for regenerative medicine and tissue models of disease.

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Precision medicine is a rapidly growing approach to health care that focuses on finding treatments and interventions that work for people based on their genetic makeup, rather than their symptoms. Zeeshan Ahmed, director of the new Ahmed Lab at Rutgers Institute for Health, Health Care Policy and Aging Research, discusses the future of precision medicine, what needs to be done to successfully analyze the data necessary to develop individualized treatments and the role genetics play during the COVID-19 pandemic.

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Why do some people have severe reactions to COVID whereas others do not? Are there overlooked or unexplained factors in how people respond to the COVID virus connected to their gut microbiome? Could microbiome predict the severity of illness among those exposed to the virus?

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An international, first-of-its-kind cardiology trial used personalized genetic testing to reduce by 34 per cent the number of serious adverse events following balloon angioplasty, a treatment for the most common form of heart disease.

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Researchers from the Icahn School of Medicine used a novel genetic sequencing technology to identify the genetic cause of—and a treatment for—a previously unknown severe auto inflammatory syndrome affecting an 18-year-old girl since infancy.

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Coriell Life Sciences case study: A DNA analysis and precision medicine algorithm generates a detailed personalized medicine report for participants of the Teachers’ Retirement System of the State of Kentucky.

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Latest research from Affirmativ Health succeeds in treating cognitive decline using personalized, precision medicine.

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Post-translational modification analysis may broadly identify new biomarkers of cancer drivers for a much more precise prediction of patient responses to treatments. A recent study demonstrates this diagnostic alternative for neuroendocrine neoplasms driven by a protein kinase called Cdk5.

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Coriell Life Sciences is rolling out a new tool in the fight against COVID-19: personalized COVID-19 Risk Scores designed to enable safer re-opening and return to work plans (especially given the recent release of the CDC guidelines for re-opening).

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Is personalized medicine cost-effective? Researchers have answered that question for one medical treatment, genotype-guided antiplatelet therapy for acute coronary syndrome patients with PCI. Their study uses pharmacogenomics and economic analysis of real-world clinical data.

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The College of American Pathologists (CAP) released a new evidence- based guideline “Collection and Handling of Thoracic Small Biopsy and Cytology Specimens for Ancillary Studies” to clarify procedures and methods to optimize test outcomes.

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The promise of personalized medicine has not fully materialized, say two McMaster researchers, because the full sophistication of the genetic blueprint has a more complex and far-reaching influence on human health than scientists had first realized.

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Is the future of personalized medicine out of this world? Cedars-Sinai is trying to find out by launching special stem cells into space to see if they multiply better there. The Cedars-Sinai Board of Governors Regenerative Medicine Institute is partnering with Space Tango of Lexington, Kentucky, to send induced pluripotent stem cells (iPSCs) to the International Space Station. The first flight for the project, funded by a $1.5 million award from NASA, could occur as early as next year.

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Women undergoing radiotherapy for many cancers are more likely than men to be cured, but the side effects are more brutal, according to one of Australia’s most experienced radiation oncology medical physicists.

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Just released is the April edition of SLAS Technology featuring cover article, “CURATE.AI: Optimizing Personalized Medicine with Artificial Intelligence,” by Agata Blasiak, Ph.D., Jeffrey Khong, Ph.D., and Theodore Kee, Ph.D., (University of Singapore and The N.1 Institute for Health).

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Obesity is among the most common complex diseases in the United States and has been a stubborn public health challenge for decades. Its causes are wide ranging, but genetic heritability is increasingly understood to be an influential factor in determining a person’s risk for the disease. Coriell researchers have found a new genetic indicator of obesity risk and bolstered the understood importance of one gene’s role in obesity risk.

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John Theurer Cancer Center at Hackensack University Medical Center is the only site in New Jersey and one of just 17 in the country participating in a multicenter international Phase II study of an innovative personalized cancer vaccine being evaluated in combination with pembrolizumab immunotherapy in patients with melanoma that has been surgically removed but has a high risk of coming back. The hope is that the vaccine can prime a patient's immune system to be more responsive to immunotherapy and reduce the risk of cancer recurrence.

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Using "BPA-free" plastic products could be as harmful to human health -- including a developing brain -- as those products that contain the controversial chemical, suggest scientists in a new study led by the University of Missouri and published in the Proceedings of the National Academy of Sciences.

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Rutgers biomedical engineers have developed a “bio-ink” for 3D printed materials that could serve as scaffolds for growing human tissues to repair or replace damaged ones in the body. Their study was published in the journal Biointerphases.

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Professor Yuval Shaked, head of the Technion Integrated Cancer Center, presents an outline for therapy that will prevent the development of cancer treatment resistance, with suggestions about how the information can be used clinically.

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Personalised cancer treatment is one step closer to becoming a reality for more patients, thanks to a Cancer Council Beat Cancer Project grant awarded to University of South Australia researcher Dr Stephanie Reuter Lange to explore how computer-based modelling can optimise cancer treatment and remove the need for expensive clinical trials.

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New findings show that individual variations in the brain’s structural connectome (map of neural connections) define a specific structural fingerprint with a direct impact on the functional organization of individual brains.

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Mayo Clinic is creating a library of genomic sequencing data on 100,000 consented Mayo Clinic participants to advance research and patient care.

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Fred Hutchinson Cancer Research Center announced today that Dr. Thomas J. Lynch Jr. will become the center’s new president and director. Lynch, a well-known cancer leader with expertise in solid tumor research, precision medicine and immuno-oncology, will join Fred Hutch Feb. 1.

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A collaborative study of researchers from Thomas Jefferson University, Sbarro Institute for Cancer Research and Molecular Medicine of Temple University, University of Siena, and from the Spanish Center for the Applied Medical Research (CIMA) of the University of Navarra have discovered a novel targetable axis in mesothelioma patients.

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The National Institutes of Health (NIH) has selected Joshua C. Denny, MD, MS, vice president of Personalized Medicine at Vanderbilt University Medical Center (VUMC), to be the Chief Executive Officer of the federal All of Us Research Program.

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NCCN Guidelines for Genetic/Familial Risk Assessment: Breast, Ovarian, and Pancreatic updated with new and expanded sections on risk assessment and management related to three major cancer types.

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Ge Wang, the Clark and Crossan Endowed Chair of biomedical engineering and director of the Biomedical Imaging Center at Rensselaer Polytechnic Institute, has been named a fellow of the National Academy of Inventors (NAI).

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The lack of understanding of health providers and patients is a major barrier to the integration of genomics into personalized medicine. This innovative certificate program will provide health professionals and scientists with the requisite skills they need to interpret and incorporate this new knowledge into a patient care model that emphasizes individually tailored prevention, diagnosis and treatment.

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Researchers from Penn State College of Medicine identified a new gene mutation that may cause a type of familial thyroid cancer.

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The cost of genetic testing has steadily declined since the human genome was first mapped in 2003, allowing large employers, healthcare systems, and pension funds to adopt an upstream approach to preventative care by offering genetic testing and precision medicine as proactive wellness benefits.

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Wearable, smart technologies are transforming the ability to monitor and improve health, but a decidedly low-tech commodity — the humble toilet — may have potential to outperform them all.

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A group of researchers at the University of Michigan Rogel Cancer Center is laying the foundations for a new, “multi-omic” approach that could help determine the drugs to which a particular triple-negative tumor will be most likely to respond based on the totality of its molecular features.

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In a bid to determine factors linked to the most debilitating forms of multiple sclerosis (MS), Johns Hopkins Medicine researchers say they have identified three so-called “complement system” genes that appear to play a role in MS-caused vision loss. The researchers were able to single out these genes — known to be integral in the development of the brain and immune systems — by using DNA from MS patients along with high-tech retinal scanning.

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In the first retrospective cohort study of the functional medicine model, Cleveland Clinic researchers found that functional medicine was associated with improvements in health-related quality of life. The study was published today in the Journal of the American Medical Association Network Open.