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A reporter's PressPass is required to access this story until the embargo expires on 27-Jan-2015 5:00 AM EST

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Study Finds Potential New Drug Target for Lung Cancer

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A new study by University of Kentucky Markey Cancer Center researchers suggests that targeting a key enzyme and its associated metabolic programming may lead to novel drug development to treat lung cancer.

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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 28-Jan-2015 1:00 PM EST

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Scientists Identify New Mechanism to Aid Cells Under Stress

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A team of biologists has identified new details in a cellular mechanism that serves as a defense against stress. The findings potentially offer insights into tumor progression and neurodegenerative diseases, such as Parkinson’s and Alzheimer’s — the cell’s inability to respond to stress is a major cause of these diseases.

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Study: Even with Copayments for Nonurgent Care, Medicaid Patients Still Rely on ERs

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How can states and federal government provide adequate health care to poor people, without overburdening taxpayers or leaving health care providers with billions in unpaid bills? That thorny problem is especially challenging in the aftermath of a recession and congressional mandates expanding Medicaid eligibility.

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Brain’s On-Off Thirst Switch Identified

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Neurons that trigger our sense of thirst—and neurons that turn it off—have been identified by Columbia University Medical Center neuroscientists. The paper was published today in the online edition of Nature.

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Nanoshuttle Wear and Tear: It’s the Mileage, Not the Age

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As nanomachine design advances, researchers are moving from wondering if the nanomachine works to how long it will work—an important question as there are so many potential applications, e.g., for medical uses including drug delivery and early diagnosis. Columbia Engineering Professor Henry Hess observed a molecular shuttle powered by kinesin motor proteins and found it to degrade when operating, marking the first time degradation has been studied in detail in an active, autonomous nanomachine.

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Ribose-Seq Identifies and Locates Ribonucleotides in Genomic DNA

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Researchers have developed and tested a new technique known as ribose-seq that allows them to determine the full profile of ribonucleotides -- RNA fragments -- embedded in genomic DNA.

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Researchers Identify Brain Circuit That Regulates Thirst

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Howard Hughes Medical Institute scientists have identified a circuit in the brains of mice that regulates thirst. When a subset of cells in the circuit is switched on, mice immediately begin drinking water, even if they are fully hydrated. A second set of cells suppresses the urge to drink.

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How Ionic: Scaffolding Is in Charge of Calcium Carbonate Crystals

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Nature packs away carbon in chalk, shells and rocks made by marine organisms that crystallize calcium carbonate. Now, research suggests that the soft, organic scaffolds in which such crystals form guide crystallization by soaking up the calcium like an “ion sponge,” according to new work in Nature Materials. Understanding the process better may help researchers develop advanced materials for energy and environmental uses, such as for removing carbon dioxide from the atmosphere.