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Ovarian Cancer-Specific Markers Set the Stage for Early Diagnosis, Personalized Treatments

Researchers at University of California, San Diego School of Medicine and Moores Cancer Center have now identified six mRNA isoforms (bits of genetic material) produced by ovarian cancer cells but not normal cells, opening up the possibility that they could be used to diagnose early-stage ovarian cancer. What’s more, several of the mRNA isoforms code for unique proteins that could be targeted with new therapeutics.

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Study Suggests New Way of Preventing Diabetes-Associated Blindness

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Reporting on their study with lab-grown human cells, researchers at The Johns Hopkins University and the University of Maryland say that blocking a second blood vessel growth protein, along with one that is already well-known, could offer a new way to treat and prevent a blinding eye disease caused by diabetes.

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Researchers Unveil New Gene Subgroup in Prostate Cancer

Prostate cancer researchers have drawn a molecular portrait that provides the first complete picture of localized, multi-focal disease within the prostate and also unveils a new gene subgroup driving it.

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Removing Mutant p53 Significantly Regresses Tumors, Improves Cancer Survival

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Removing accumulated mutant p53 protein from a cancer model showed that tumors regress significantly and survival increases. This finding, by an international team of cancer researchers led by Ute Moll, MD, Professor of Pathology at Stony Brook University School of Medicine, is reported in a paper published advanced online May 25 in Nature.

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One Step Closer to a Single-Molecule Device

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Columbia Engineering professor Latha Venkataraman has designed a new technique to create a single-molecule diode, and, in doing so, she has developed molecular diodes that perform 50 times better than all prior designs. Venkataraman’s group is the first to develop a single-molecule diode that may have real-world technological applications for nanoscale devices.

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Engineering Phase Changes in Nanoparticle Arrays

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Scientists at the U.S. Department of Energy's Brookhaven National Laboratory have just taken a big step toward the goal of engineering dynamic nanomaterials whose structure and associated properties can be switched on demand. In a paper appearing in Nature Materials, they describe a way to selectively rearrange the nanoparticles in three-dimensional arrays to produce different configurations, or phases, from the same nano-components.

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DNA Double Helix Does Double Duty in Assembling Arrays of Nanoparticles

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In a new twist on the use of DNA in nanoscale construction, scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory and collaborators put synthetic strands of the biological material to work in two ways: They used ropelike configurations of the DNA double helix to form a rigid geometrical framework, and added dangling pieces of single-stranded DNA to glue nanoparticles in place.

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Biodiversity: Eleven New Species Come to Light in Madagascar

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Madagascar is home to extraordinary biodiversity, but in the past few decades, the island’s forests and associated biodiversity have been under greater attack than ever. Rapid deforestation is affecting the biotopes of hundreds of species, including the panther chameleon, a species with spectacular intra-specific colour variation. A new study by Michel Milinkovitch, professor of genetics, evolution, and biophysics at the University of Geneva (UNIGE), led in close collaboration with colleagues in Madagascar, reveals that this charismatic reptilian species, which is only found in Madagascar, is actually composed of eleven different species. The results of their research appear in the latest issue of the Molecular Ecology journal. They also discuss the urgent need to protect Madagascar’s habitats.

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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 27-May-2015 2:00 PM EDT

Life

Education

Stony Brook University Celebrates 55th Commencement Ceremony Honoring Billy Joel and Charles B Wang with Honorary Degrees

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At Stony Brook University’s 55th commencement ceremony today at Kenneth P. LaValle Stadium, 6,298 students had their degrees conferred, becoming the University’s newest alumni. They joined more than 155,000 of their forerunners around the globe whose lives and work personify the mission of Stony Brook