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Zerenex™ (Ferric Citrate) Long-Term Phase 3 Study Results Published in the Journal of the American Society of Nephrology

Keryx Biopharmaceuticals, Inc. announced the publication of results from the long-term, randomized, active control Phase 3 study of Zerenex (ferric citrate), the Company's investigational oral ferric iron-based phosphate binder, for the treatment of hyperphosphatemia in patients with end-stage renal disease (ESRD) on dialysis. The PERFECTED study (PhosphatE binding and iRon delivery with FErric CiTrate in EsrD) was published online today in the Journal of the American Society of Nephrology (JASN).

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Ferric Citrate May Reduce Dialysis Patients’ Need for Multiple Medications

• Ferric citrate effectively reduced blood phosphorus levels while increasing iron stores and decreasing the need for intravenous iron and anemia medications in dialysis patients. • The medication may help reduce complications and costs associated with kidney disease care.

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Genetic Test Helps Predict Which Children with Kidney Disease Will Respond to Standard Therapy

• Among children with sporadic nephrotic syndrome, genetic mutations in the kidney’s filtration barrier were frequently linked with a lack of response to immunosuppressive treatments. • The genetic test was even more predictive than a kidney biopsy for identifying children who would not benefit from immunosuppressive therapies.

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Social and Behavioral Sciences

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Experts: Gun Violence Prevention Requires Public Health Approach

Preventing gun violence will require a scientific public health approach and recognition of the limits of predicting individual cases of violence, according to experts slated to speak at the American Psychological Association’s 122nd Annual Convention.

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Social and Behavioral Sciences

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Experts: Humans Share Fairness Concerns with Other Species

Humans aren’t the only species to react strongly to actions they consider unfair. A similar drive for fairness in monkeys and some dogs may offer insight into people’s desire for equity, according to experts presenting at the American Psychological Association’s 122nd Annual Convention.

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Female Triathletes at Risk for Pelvic Floor Disorders and Other Complications

Female triathletes are at risk for pelvic floor disorders, decreased energy, menstrual irregularities and abnormal bone density, according to researchers at Loyola University Health System (LUHS). These data were presented today at the American Urogynecologic Society 2014 Scientific Meeting in Washington, DC.

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Scientists Discover Genetic Switch That Can Prevent Peripheral Vascular Disease in Mice

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Millions of people in the United States have a circulatory problem of the legs called peripheral vascular disease. It can be painful and may even require surgery in serious cases. This disease can lead to severe skeletal muscle wasting and, in turn, limb amputation.

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Tissue Collection Aids Search for Neurologic and Neuromuscular Disease Causes and Cures

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Like other major research centers studying genetic causes of uncommon and poorly understood nervous system disorders, Cedars-Sinai maintains a growing collection of DNA and tissue samples donated by patients. What sets Cedars-Sinai’s Repository of Neurologic and Neuromuscular Disorders apart is its special emphasis on tissue collection – part of its focus on creating future individualized treatments for patients.

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Nuclear Engineer X. George Xu Named Edward E. Hood Jr. Endowed Chair of Engineering at Rensselaer Polytechnic Institute

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Nuclear engineering expert X. George Xu has been named the Edward E. Hood Jr. Endowed Chair of Engineering at Rensselaer Polytechnic Institute.

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ORNL Study Reveals New Characteristics of Complex Oxide Surfaces

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A combination of microscopy and data processing has given researchers an unprecedented look at the surface of a material known for its unusual physical and electrochemical properties.

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