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Cellular Recycling Complexes May Hold Key to Chemotherapy Resistance

Upsetting the balance between protein synthesis, misfolding, and degradation drives cancer and neurodegeneration. Recent cancer treatments take advantage of this knowledge with a class of drugs that block protein degradation, known as proteasome inhibitors. Widespread resistance to these drugs limits their success, but Whitehead researchers have discovered a potential Achilles heel in resistance. With such understandings researchers may be able to target malignancy broadly, and more effectively.

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Expert Available: Cutting-Edge Molecular Diagnostic Tests Provide Benefit for Children with Autism Spectrum Disorders

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Autism spectrum disorders (ASD) are not completely understood neurodevelopmental disorders diagnosed solely on the basis of behavioral assessments of social, communicative and repetitive symptoms. Though behaviorally distinctive and reliably identified by experienced clinicians, ASD is clinically and genetically extremely diverse, affecting each patient differently. Efforts to identify subsets of patients with similar outcomes and chances of recurrence has been difficult, said Judith Miles, M.D., P.h.D., a University of Missouri child health physician and researcher specializing in medical genetics, in an invited editorial published Sept.1 in the Journal of the American Medical Association (JAMA).

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Law and Public Policy

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Politics Will Prevent Real Economic Reform in China, Says Iowa State University Professor

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Recovering from the economic crisis that rippled through the global markets will be long and difficult for China, said Jonathan Hassid, an assistant professor of political science at Iowa State University who studies Chinese news media and symbolic political messaging.

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Surge in Bicycle Injuries to Riders Over 45

The incidence of bicycle accidents has increased significantly in the U.S. in recent years, with many serious injuries occurring among riders older than 45, according to a new study led by UC San Francisco.

Life

Social and Behavioral Sciences

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The More the Merrier for Animals That Synchronize Their Behavior

Social interaction could be the mechanism that allows animals living in groups to synchronize their activities, whether it’s huddling for warmth or offering protection from predators.

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Social and Behavioral Sciences

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Economic Security Requires New Measures of Well-Being

Economic well-being for low-income families in the U.S. is often determined by federal measures, but a new study by a University at Buffalo research team suggests that such a definition is unrealistically narrow.

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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 9-Sep-2015 4:30 PM EDT

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NOWDiagnostics Inc. Acquires Canada’s ZBx Corporation

NOWDiagnostics Inc., based in Springdale, Ark., recently completed its acquisition of ZBx Corporation of Canada, a move that brings the company closer to its vision of a world where people have greater access to information concerning their health.

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When Stroke Patients Undergo Surgery to Remove Blood Clots, What Anesthesia Works Best?

As more stroke patients undergo minimally invasive procedures to stop strokes in progress, physicians are debating the best way to anesthetize patients -- general anesthesia or conscious sedation?

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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 2-Sep-2015 5:05 PM EDT