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New Subsets of Lung Cancer with KRAS Gene Mutations Identified

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Mutations of the KRAS gene are commonly known to lead to cancer. However, deeper understanding of exactly how they do this continues to be explored by cancer researchers.

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New Combination of Immunotherapy Drugs is Safe, Shrinks Tumors in Metastatic Melanoma Patients

Once again, researchers at Penn’s Abramson Cancer Center have extended the reach of the immune system in the fight against metastatic melanoma, this time by combining the checkpoint inhibitor tremelimumab with an anti-CD40 monoclonal antibody drug.

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A New Lease on Life for Prostate Tissue

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What if a prostate cancer patient could learn which anti-cancer treatments would work best for him without having to swallow a single pill or endure a single intravenous line or injection? Research from Rutgers Cancer Institute of New Jersey involving the development of human organoid prostate models could have implications for how future therapy is guided for some of this population.

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Gene Signatures Predict Doxorubicin Response in K9 Osteosarcoma

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New work by the University of Colorado Cancer Center presented at AACR 2015 demonstrates a gene expression model that predicts canine osteosarcoma response to doxorubicin, potentially allowing veterinary oncologists to better choose which drug to use with their patients.

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Driver of Non-Small Cell Lung Cancer, FGFR1, Also Present in 23 Percent of Small Cell Lung Cancer

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Results presented at AACR 2015 show oncogene recognized in NSCLC in small cell lung cancer, as well, implying that medicines in development for the first may be applicable to second.

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Shared Risk Factors Lead to Diabetes, Heart Disease and Cancer, Says Major AACR Symposium

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In a major symposium at the American Association for Cancer Research (AACR) Annual Meeting 2015, University of Colorado Cancer Center investigator Tim Byers, MD, MPH, examines research demonstrating the link between cancer, diabetes and cardiovascular disease.

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Investigational Personalized Cellular Therapy Tolerated Well by Patients with Advanced Mesothelioma, Ovarian and Pancreatic Cancers

Genetically modified versions of patients’ own immune cells successfully traveled to tumors they were designed to attack in an early-stage trial for mesothelioma and pancreatic and ovarian cancers at the Perelman School of Medicine at the University of Pennsylvania. The data adds to a growing body of research showing the promise of CAR T cell technology. The interim results will be presented at the American Association for Cancer Research (AACR) Annual Meeting 2015, April 18-22.

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Immunotherapy Drug Pembrolizumab Shows Early Promise for Mesothelioma Patients

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The PD-1 inhibitor pembrolizumab, a cancer immunotherapy drug, shrank or halted growth of tumors in 76 percent of patients with pleural mesothelioma, a rare and deadly form of cancer that arises in the outer lining of the lungs and internal chest wall, according to a new study from researchers in the Perelman School of Medicine at the University of Pennsylvania. Patients diagnosed with the disease, which is tied to exposure to asbestos, have a median survival rate of about one year.

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Literacy App Improves School Readiness in At-Risk Preschoolers

Using mobile apps in preschool classrooms may help improve early literacy skills and boost school readiness for low-income children, according to research by NYU’s Steinhardt School of Culture, Education, and Human Development.

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Ludwig’s Tyler Jacks Speaks About Mouse Models and Use of Genome-Editing Tools to Hasten Discovery in Cancer Research

Ludwig MIT researcher Tyler Jacks will deliver an address titled “Engineering the Cancer Genome” during the opening plenary session of the 2015 Annual Meeting of the American Association for Cancer Research on insights gleaned from mouse models of cancer.