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Medicine

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St. Jude Children's Research Hospital, J. Paul Taylor, Neuron, ALS, Lou Gehrig's Disease, , frontotemporal dementia , Frontotemporal Dementia, Amyotrophic Lateral Sclerosis, phase separation, ALS treatment

Researchers Discover Fundamental Pathology Behind ALS

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A team led by scientists at St. Jude Children’s Research Hospital and Mayo Clinic has identified a basic biological mechanism that kills neurons in amyotrophic lateral sclerosis (ALS) and in a related genetic disorder, frontotemporal dementia (FTD), found in some ALS patients. ALS is popularly known as Lou Gehrig’s disease. The researchers were led by J. Paul Taylor, M.D., Ph.D., chair of the St. Jude Cell and Molecular Biology Department and a Howard Hughes Medical Institute investigator; and Rosa Rademakers, Ph.D., of the Mayo Clinic in Jacksonville, Florida. The findings appear today in the journal Neuron.

Medicine

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John Schuetz, St. Jude Children's Research Hospital, Pharmaceutical Science, AML, Acute Myeloid Leukemia, heme synthesis, HEME, JCI Insight, MYCN, UROD

Discovery Points to Drugs That Would ‘Short-Circuit’ Deadly Leukemia

St. Jude Children’s Research Hospital scientists have found that cells of a deadly acute myeloid leukemia can be killed by blocking production of a molecular “battery.”

Medicine

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St. Jude Children's Research Hospital, Immunology, Influenza, Influenza Infection, high-risk influenza, IFITM3 proteins, Anti-viral, Immune Response

Newly Identified Genetic Marker May Help Detect High-Risk Flu Patients

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Researchers led by St. Jude Children’s Research Hospital have identified a genetic variation associated with influenza severity and the supply of killer T cells that help patients fight the infection.

Medicine

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ovarian insuffiency, Fertility Preservation, cancer survivor advocacy, St. Jude LIFE , Radiation effects, cancer therapy effects

Improved Risk Recognition Expected to Enhance Fertility Preservation for Cancer Patients

St. Jude Children’s Research Hospital has advanced understanding of risk factors for premature ovarian insufficiency, which should aid identification of cancer patients most likely to benefit from fertility preservation.

Medicine

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Charles Mullighan, St. Jude Children's Research Hospital, Jinghui Zhang, genomic sequencing, Acute Lymphoblastic Leukemia, genomic analysis, T-ALL, T-All Leukemia

First Large-Scale Genomic Analysis of Key Acute Leukemia Will Likely Yield New Therapies

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Charting the genomic landscape of T-lineage acute lymphoblastic leukemia patients revealed insights that will guide research and help to lay the foundation for more targeted therapy.

Medicine

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St. Jude Children's Research Hospital, T Cells, immune-checkpoint blockade , immune checkpoint blockade therapy, epigenitcs, T cell exhaustion, Chronic viral infection, HIV, epigenetic control, Immunology

Researchers Chart Pathway to ‘Rejuvenating’ Immune Cells to Fight Cancers and Infections

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St. Jude Children’s Research Hospital discovery of the mechanism of T cell exhaustion will lead to treatments to enhance immunotherapies against cancers and such viruses as HIV

Medicine

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St. Jude Children's Research Hospital, Immunology, Antigens, T Cell, Immune, Paul Thomas, TCRdist, Immunotherapy

Researchers Create a ‘Rosetta Stone’ to Decode Immune Recognition

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St. Jude Children’s Research Hospital and Fred Hutchinson Cancer Research Center have developed an algorithm that predicts T cell recognition of antigens and sets the stage to more effectively harness the immune system

Medicine

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St. Jude Children's Research Hospital, Medulloblastoma, sonic hedgehog pathway, SHH medulloblastoma, Smoothened, primary cilium, Phospholipase A2, Cell And Molecular Research, Cell and Molecular Biology

Researchers Identify a Key Controller of Biological Machinery in Cell’s ‘Antenna’

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St. Jude Children’s Research Hospital discovery of a regulatory enzyme working at the primary cilium could lead to treatments for the brain tumor medulloblastoma

Medicine

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Influenza, Viral, Immunology, BEZ235, St. Jude Children's Research Hospital, Influenza Virus

A New Strategy Reported to Combat Influenza and Speed Recovery

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St. Jude Children’s Research Hospital scientists have used a drug being developed to fight solid tumors to restore normal metabolism in flu-infected cells and reduce viral production without the threat of drug resistance

Medicine

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Pediatric Cancer Genome Project, PCGP, St. Jude Children's Research Hospital, Retinoblastoma, Eye Cancer, genomic analysis, Michael Dyer, proteinpaint

St. Jude Maps Genome Organization to Link Retinal Development and Retinoblastoma

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A map of the genome organization and DNA modifications that control growth of normal and cancerous retinal cells offers scientists a new path to understanding retinoblastoma and degenerative retinal diseases.







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