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Medicine

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St. Jude Children's Research Hospital, Immunology, Antigens, T Cell, Immune, Paul Thomas, TCRdist, Immunotherapy

Researchers Create a ‘Rosetta Stone’ to Decode Immune Recognition

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St. Jude Children’s Research Hospital and Fred Hutchinson Cancer Research Center have developed an algorithm that predicts T cell recognition of antigens and sets the stage to more effectively harness the immune system

Medicine

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St. Jude Children's Research Hospital, Medulloblastoma, sonic hedgehog pathway, SHH medulloblastoma, Smoothened, primary cilium, Phospholipase A2, Cell And Molecular Research, Cell and Molecular Biology

Researchers Identify a Key Controller of Biological Machinery in Cell’s ‘Antenna’

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St. Jude Children’s Research Hospital discovery of a regulatory enzyme working at the primary cilium could lead to treatments for the brain tumor medulloblastoma

Medicine

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Influenza, Viral, Immunology, BEZ235, St. Jude Children's Research Hospital, Influenza Virus

A New Strategy Reported to Combat Influenza and Speed Recovery

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St. Jude Children’s Research Hospital scientists have used a drug being developed to fight solid tumors to restore normal metabolism in flu-infected cells and reduce viral production without the threat of drug resistance

Medicine

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Pediatric Cancer Genome Project, PCGP, St. Jude Children's Research Hospital, Retinoblastoma, Eye Cancer, genomic analysis, Michael Dyer, proteinpaint

St. Jude Maps Genome Organization to Link Retinal Development and Retinoblastoma

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A map of the genome organization and DNA modifications that control growth of normal and cancerous retinal cells offers scientists a new path to understanding retinoblastoma and degenerative retinal diseases.

Medicine

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Immunology, kanneganti, sweet syndrome, neutrophilic dermatosis, autoinflammatory disease , ptpn6, Immune Response

Researchers Unlock an Immunity ‘Black Box’

Mapping the biological machinery of the inflammatory skin disease neutrophilic dermatosis offers multiple targets for treating inflammatory disorders.

Medicine

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St. Jude Children's Research Hospital, Hearing, auditory function, Hearing Loss, Hair Cell Regeneration, Jian Zuo, Developmental Neurobiology, Hair Cells, ATOH1

Success of Sensory Cell Regeneration Raises Hope for Hearing Restoration

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St. Jude Children’s Research Hospital scientists have regenerated immature auditory hair cells in adult mice by manipulating two genes. The research offers clues for better treatment of hearing loss.

Medicine

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hematopoetic stem , Hematopoietic Stem Cells, Stem Cells, Blood Developement, Blood Cells, Transplant, Zebrafish model, Zebrafish, St. Jude Children's Research Hospital, Hematology

Time-Lapse Video Reveals Cells Essential for ‘Birth’ of Blood Stem Cells

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St. Jude Children’s Research Hospital study examines origin of blood stem cells during development and offers clues for making “donor blood” in the laboratory for therapeutic use

Science

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Cell Death Process, Cell Death, Cell Death Mechanism, Protein, Necroptosis, Cancer Treatment, Cancer Prevention and Control, MLKL, Transplant, ESCRT

Rescue Protein Gives Doomed Cells a Stay of ‘Execution’

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A research team led by St. Jude Children’s Research Hospital immunologists has discovered how a set of proteins delays the “executioner” machinery that kills damaged or infected cells in a process called necroptosis.

Medicine

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Genetic Screening, Genome Sequence, whole genome, exome sequencing, Pediatric Cancer, BRCA, Leslie Robison, Life After Cancer Treatment, Jinghui Zhang, Childhood Cancer, cancer surveillance, Cancer Survivor

Study Finds More Childhood Cancer Survivors Would Likely Benefit From Genetic Screening

St. Jude Children’s Research Hospital has completed the first whole genome sequencing of cancer survivors and found that 12 percent of childhood cancer survivors carry mutations linked to an increased risk of cancer

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Caution Needed for Drugs in Development for Most Common Malignant Pediatric Brain Tumor

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Inhibiting the Ezh2 enzyme may be counterproductive for treatment of certain cancers, including the aggressive brain tumor Group 3 medulloblastoma







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