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Bortezomib, Kidney Transplant

Clinical Trial Does Not Support the Use of Bortezomib for Kidney Transplant Recipients

• In a trial of kidney transplant recipients with late antibody-mediated rejection, treatment with bortezomib, a type of proteasome inhibitor, failed to improve the function of transplanted kidneys and prevent immunologic tissue injury. • Bortezomib treatment was also linked with gastrointestinal and hematologic toxicity.

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Kidney Failure, Survival

Survival Rates Are Improving for Individuals with Kidney Failure

• In the United States, the excess risk of kidney failure–related death decreased by 12% to 27% over any 5-year interval between 1995 and 2013. • Decreases in excess mortality over time were observed for all ages and both during treatment with dialysis and during time with a functioning kidney transplant.

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ASN Partners with VA Center for Innovation on My Kidney Nutrition App Features CHALLENGEWashington, DC (December 12, 2017) — Around 17% of American Adults Have Chronic Kidney Disease (CKD), and the Rate of Prevalence Is Higher for US Veterans. CKD,

Around 17% of American adults have chronic kidney disease (CKD), and the rate of prevalence is higher for US Veterans. CKD, if not treated appropriately, can ultimately lead to kidney failure requiring either dialysis or a transplant.

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kidney discard, Transplantation

Many Donor Kidneys that Are Discarded May Be Suitable for Transplantation

• In an analysis of pairs of kidneys from the same donor in which 1 kidney was used but the other was discarded, the kidneys that were used tended to perform well. • The majority of discarded kidneys could have potentially been transplanted with good outcomes.

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Immune Cells, Kidney Disease

Study Provides Insights on Immune Cells Involved in Kidney Disease

• New research indicates that the role of dendritic cells in kidney inflammation is more complex than previously thought. Different types of dendritic cells communicate with each other to control the magnitude of the immune response. • The findings may lead to a better understanding of various types of kidney disease.

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Kidney Transplant

Study Identifies Genes Involved in Tolerance following Kidney Transplantation

• In tissue samples from patients who received kidney transplants without the need for chronic immunosuppression, researchers found increased expression of many genes associated with the regulation of certain immune cells. • The findings provide an improved understanding of transplant organ acceptance and rejection.

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Kidney Stones, Pregnancy

A History of Kidney Stones May Contribute to Certain Complications During Pregnancy

• In young women, a history of kidney stones was associated with metabolic and hypertensive complications. • Results from the study will be presented at ASN Kidney Week 2017 October 31–November 5 at the Ernest N. Morial Convention Center in New Orleans, LA.

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Veterans Affairs, Kidney Transplantation

VA Patients Face Disparities in Kidney Transplantation

• From 2004 to 2016, VA patients had lower rates of transplantation compared with patients with Medicare or private insurance. • VA patients also had a higher rate of mortality on the waiting list compared with privately insured patients. • Results from the study will be presented at ASN Kidney Week 2017 October 31–November 5 at the Ernest N. Morial Convention Center in New Orleans, LA.

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Air Pollution, Kidney Disease

Air Pollution Causes Millions of Cases of Kidney Disease Each Year

• The estimated global burden of chronic kidney disease attributable to fine particulate matter is more than 10.7 million cases per year. • Results from the study will be presented at ASN Kidney Week 2017 October 31–November 5 at the Ernest N. Morial Convention Center in New Orleans, LA.

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metabolic acidosis, Kidney Disease

Novel Treatment May Benefit Patients with Metabolic Acidosis and Kidney Disease

• A new study demonstrated that TRC101, a hydrochloric acid binder for the treatment of metabolic acidosis associated with chronic kidney disease, provided a rapid and sustained average increase in serum bicarbonate. • All adverse effects were mild or moderate.







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