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Medicine

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Malaria, Parasite, Infection

Parasites Suck It Up

Depletion of a fatty molecule in human blood propels malaria parasites to stop replicating and causing illness in people and instead to jump ship to mosquitoes to continue the transmission cycle, according to a new study by an international research team.

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Cancer Cell

Gene Expression Study Reveals “Hidden” Variability in How Cancer Cells Respond to Drugs

Drug exposure can cause significant changes in gene expression without affecting growth or survival in some cell lines, highlighting strategies to better evaluate drug effectiveness.

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Ammonia, Harvard Medical School, Marcia Haigis, Breast Cancer, Recycling

New Study Reveals Breast Cancer Cells Recycle Their Own Ammonia Waste as Fuel

Breast cancer cells recycle ammonia, a waste byproduct of cell metabolism, and use it as a source of nitrogen to fuel tumor growth. The insights shed light on the biological role of ammonia in cancer and may inform the design of new therapeutic strategies to slow tumor growth.

Medicine

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NIH, Awards, high-risk, Research, Scientists, high reward

Harvard Medical School Scientists Receive NIH Director's Awards

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Four Harvard Medical School scientists are among 86 recipients nationwide honored by the National Institutes of Health High-Risk, High-Reward Research Program.

Medicine

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drug value, Drug Cost, drug price, Preterm Birth, Progestin, orphan drug

Sticker Shock

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An analysis reveals that the branded form of a synthetic progestin for the prevention of recurrent preterm births costs 5,000 percent more than the compounded, made-to-order version of the medication despite having the same active ingredients and being clinically interchangeable.

Medicine

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spine formation, Spine, spine defects, Embryonic Development

How to Grow a Spine

Working with mouse cells, Harvard Medical School scientists have successfully recreated the segmentation clock that drives spine formation during embryonic development. Insights can illuminate normal spine development, understanding of spinal malformations such as scoliosis and spina bifida.

Science

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Africa, Ancient Dna, Genetic Analysis

Long-Awaited Landscape

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The first large-scale study of ancient human DNA from sub-Saharan Africa opens a long-awaited window into the identity of prehistoric populations in the region and how they moved around and replaced one another over the past 8,000 years.

Medicine

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Autism, Gender, Pediatrics, Genetic Counseling, risk, Recurrence, Siblings, Autism Spectrum Disorder (ASD)

Autism's Gender Patterns

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Largest study to date identifies gender-specific patterns of autism and related disorders occurrence among sibling pairs.

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Circadian Clock, Circadian Rhythm

Circadian Clock’s Inner Gears

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New study identifies a handful of molecular machines that run circadian clocks, biomechanical oscillators that control physiology, metabolism and behavior on a 24-hour cycle. Findings dispel traditional view that key clock proteins act individually and provide the first structural glimpse of the body’s circadian machine. Identifying protein complexes that operate the circadian clock could eventually lead to new treatments for disorders stemming from malfunctions in the system, including sleep problems, metabolic problems and cancer.

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Bacteria, single cell , Sex, Sexual Reproduction, aphrodisiac, Eukaryote

A Touch of ERoS

Researchers interested in the evolution of multicellular life were looking for bacteria that stimulate Salpingoeca rosetta, single-cell saltwater dwellers that are the closest living relatives of animals, to form the rosette-shaped colonies that give them their name. But one bacterium had quite a different stimulating effect: It motivated S. rosetta to have sex.







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