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  • Embargo expired:
    24-Jul-2018 9:00 AM EDT

Article ID: 697514

Host Antibodies Shape Gut Microbiome by Changing Bacteria Gene Expression

The Rockefeller University Press

Researchers at the RIKEN Center for Integrative Medical Science in Japan have discovered how antibodies secreted in the gut promote the growth of beneficial bacteria. Their study, which will be published July 24 in the Journal of Experimental Medicine, shows that immunoglobulin A (IgA) antibodies can alter the expression of bacterial genes, allowing different bacterial species to cooperate with each other and form a community that can protect the body from disease.

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17-Jul-2018 10:50 AM EDT
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  • Embargo expired:
    6-Jul-2018 9:00 AM EDT

Article ID: 696790

Breast Cancer Growth Signals Are Enhanced by a Protein Outside Cells

The Rockefeller University Press

New research uncovers how a sticky protein called fibronectin promotes the activity of estrogen in breast cancer cells. The study, “Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells,” will be published July 6 in the Journal of Cell Biology (JCB).

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28-Jun-2018 12:00 PM EDT
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  • Embargo expired:
    25-Jun-2018 9:00 AM EDT

Article ID: 696245

Researchers Identify Brain Cells Responsible for Removing Damaged Neurons After Injury

The Rockefeller University Press

Researchers at the University of Virginia School of Medicine have discovered that microglia, specialized immune cells in the brain, play a key role in clearing dead material after brain injury. The study, which will be published June 25 in the Journal of Experimental Medicine, reveals that microglia gobble up the remnants of injured neurons, which could prevent the damage from spreading to neighboring neurons and causing more extensive neurodegeneration.

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19-Jun-2018 9:00 AM EDT
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  • Embargo expired:
    21-Jun-2018 9:00 AM EDT

Article ID: 696230

Researchers Uncover New Target to Stop Cancer Growth

The Rockefeller University Press

Researchers at the University of Wisconsin-Madison have discovered that a protein called Munc13-4 helps cancer cells secrete large numbers of exosomes—tiny, membrane-bound packages containing proteins and RNAs that stimulate tumor progression. The study, which will be published June 21 in the Journal of Cell Biology, could lead to new therapies that stop tumor growth and metastasis by halting exosome production.

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18-Jun-2018 12:00 PM EDT
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  • Embargo expired:
    19-Jun-2018 9:00 AM EDT

Article ID: 695996

Breast Cancer Could Be Prevented by Targeting Epigenetic Proteins, Study Suggests

The Rockefeller University Press

Researchers at the Princess Margaret Cancer Centre in Toronto have discovered that epigenetic proteins promote the proliferation of mammary gland stem cells in response to the sex hormone progesterone. The study, which will be published June 19 in the Journal of Cell Biology, suggests that inhibiting these proteins with drugs could prevent the development of breast cancer in women at high risk of the disease.

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12-Jun-2018 11:25 AM EDT
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  • Embargo expired:
    19-Jun-2018 9:00 AM EDT

Article ID: 696056

Cells can trap viruses in protein cage to stop their spread, study reveals

The Rockefeller University Press

Researchers at The Francis Crick Institute in London have discovered that cells can trap viruses in a protein cage to stop them from spreading to neighboring cells. The study, which will be published June 19 in the Journal of Cell Biology, reveals that the vaccinia virus can escape this trap by recruiting additional proteins to dismantle the cage and propel the virus out of the cell.

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13-Jun-2018 9:40 AM EDT
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  • Embargo expired:
    18-May-2018 9:00 AM EDT

Article ID: 694530

Cardiomyopathy Mutation Reduces Heart’s Ability to Vary Pumping Force, Study Reveals

The Rockefeller University Press

Researchers from Washington State University have discovered how a genetic mutation linked to hypertrophic cardiomyopathy disrupts the heart’s normal function. The study, which will be published May 18 in the Journal of General Physiology, reveals that the mutation prevents the heart from increasing the amount of force it produces when it needs to pump additional blood around the body.

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14-May-2018 1:05 PM EDT
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  • Embargo expired:
    17-May-2018 9:00 AM EDT

Article ID: 694507

Single Surface Protein Boosts Multiple Oncogenic Pathways in Acute Myeloid Leukemia, Study Reveals

The Rockefeller University Press

Researchers from the Albert Einstein College of Medicine in New York have discovered that a signaling protein elevated in patients with acute myeloid leukemia (AML) plays a much wider role in the disease than previously thought. The study, which will be published May 17 in the Journal of Experimental Medicine, raises hopes that current efforts to target this signaling protein could be a successful strategy to treat AML and other blood cancers.

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14-May-2018 10:05 AM EDT
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  • Embargo expired:
    16-May-2018 9:00 AM EDT

Article ID: 694259

Cell Type Switch Helps Colon Cancer Evade Treatment, Study Suggests

The Rockefeller University Press

Researchers in Germany have discovered that colon cancers are often resistant to existing drug treatments because they are composed of two different cell types that can replace each other when one cell type is killed. The study, which will be published May 16 in the Journal of Experimental Medicine, suggests that combination therapies targeting both cell types at once may be more effective at treating colorectal cancer, the third highest cause of cancer-related death in the United States.

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9-May-2018 9:05 AM EDT
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  • Embargo expired:
    8-May-2018 9:00 AM EDT

Article ID: 693863

Amplification of Key Cellular Organizer May Initiate Cancer, Study Suggests

The Rockefeller University Press

Cells begin to accumulate centrosomes—organelles that play a vital role during cell division—before they transform into cancer cells, according to a new study of patients with Barrett’s esophagus condition, which is associated with esophageal cancer. The research, which will be published May 8 in the Journal of Cell Biology, suggests that similar cases of centrosome amplification may contribute to the initiation and progression of a variety of human cancers.

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2-May-2018 10:10 AM EDT
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