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Medicine

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Alzheimer's Disease, clinical trial, Clinical & Translational Research, BACE, Abeta peptide, tau

Alzheimer’s Clinical Trials Get A Prevention Makeover

From trial-ready registries to genotyping parties, the field has developed new techniques and meds to stem a tide of failed trials. Alzforum’s 13-part series sums up the state of the art as presented at a recent conference.

Medicine

Science

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Alzheimer's Disease, clinical trial, Clinical & Translational Research, Dementia

Clinical Trials on Alzheimer’s Disease: Shifting the Focus to Prevention

This past decade, Alzheimer’s science has undergone a paradigm shift toward the disease’s early, silent phase. For trials, this means change at every level: new participants, new screening tools, new outcome measurements. What’s the progress?

Medicine

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Alzheimer's Disease, Frontotemporal Dementia, genetic, 23andMe

Direct-To-Consumer Genetic Testing Can Be a Trip Down the Rabbit Hole

Anyone can learn whether they carry mutations known to cause Alzheimer’s, frontotemporal dementia, and other fatal neurodegenerative diseases.

Medicine

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Alzheimer's Disease, Microglia, Genetics, Immune Cell

A Single Microglial Protein Controls Suite of Alzheimer’s Risk Genes

The discovery hints that microglia, rather than neurons, may control much of a person’s genetic susceptibility to Alzheimer’s disease.

Medicine

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Alzheimer's Disease, Amyloid, Amyloid Beta

More Support for Amyloid Hypothesis in Alzheimer's: Protective APP Mutation Lowers Aβ in Blood

A new study shows that people with a protective Aβ mutation have less of the peptide in their blood all through their lives, likely explaining why they do not get Alzheimer's. It suggests ways to prevent the disease in the vast majority of people who don’t have the mutation.

Medicine

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Alzheimer's, Obituaries

Robert Terry, Co-Founder of U.S. Alzheimer’s Research Dies at 93

A founder of U.S. Alzheimer’s research, Robert D. Terry, has died at 93. He first showed what plaques and tangles look like in the electron microscope, and linked failing cognition to withering synapses in the brain.

Science

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Neurodegeneration, Neurodegenative Disease, ALS, Alzheimer's, liquid-liquid phase transition

Gel-Like Drops of Protein and RNA Make a Splash in Neurodegenerative Diseases

At a meeting in Leuven, Belgium, a coherent picture began to emerge for how fluid pockets of proteins and RNAs contribute to health and disease.

Medicine

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Disclosure, Alzheimer’s disease, ApoE genotype, biomarkers, Amyloid

How Do You Tell a Cognitively Normal Person They Will Likely Get Alzheimer’s in the Next Few Years?

As researchers seek cognitively normal people on the way to Alzheimer’s to fill clinical prevention trials, they face the delicate task of disclosing a highly elevated, but not certain, risk of developing the disease to thousands of people. Scientists look to cancer research for cues as they recruit for the first of such trials.

Medicine

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Dominantly Inherited Alzheimer’s Network, Alzheimer’s Association International Conference, Alzheimer’s disease, Early Onset Alzheimer’s Disease, Clinical Trials, Amyloid, biomarkers

Eight Years Old and Growing Fast: DIAN Is Becoming an Alzheimer’s Movement

The Dominantly Inherited Alzheimer’s Network is churning out serial data on how Alzheimer’s disease develops in a given person over many years, and at the same time transforming how therapeutic trials are being done on this disease.

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New Insights into Microglia Help Researchers Understand Neurodegenerative Disease

Alzforum reports some of the major highlights from the recent Keystone symposium on the role of microglia in neurodegenerative disease.







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