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Science

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Diabetes, Angiogenesis, Blood Vessel Formation, Ischemic Injury, VEGF, Ras protein

Scientists Find Key to Regenerating Blood Vessels

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Florida researchers have identified a signaling pathway that is essential for angiogenesis, the growth of new blood vessels from pre-existing vessels. The findings, published in Nature Communications, may improve current strategies to improve blood flow in ischemic tissue, such as that found in atherosclerosis and peripheral vascular disease associated with diabetes.

Medicine

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MHE, Bone Tumors, exotoses, osteochondromas, palovarotene , Rare Diseases

Preclinical Study Demonstrates Promising Treatment for Rare Bone Disease

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Researchers have demonstrated that the drug palovarotene suppresses the formation of bony tumors (osteochondromas) in models of multiple hereditary exostoses (MHE). The research, published in the Journal of Bone and Mineral Research, is an important step toward an effective pharmacological treatment for MHE, a rare genetic condition that affects about 1 in 50,000 people worldwide.

Medicine

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Infectious Disease, zika, Virology, Malaria, Public Health, Birth Defects, Chloroquine, Parasitology, Developmental/Reproductive Biology, Disease In The Developing World, Infectious/Emerging Diseases, preclinical research

Anti-Malaria Drug Shows Promise as Zika Virus Treatment

California researchers have discovered that a medication used to prevent and treat malaria may also be effective for Zika virus. The drug, called chloroquine, has a long history of safe use during pregnancy, and is relatively inexpensive. The research was published today in Scientific Reports.

Medicine

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Alzheimer's Disease, Neuroscience, Amyloid, Pathology, Aging, Cell Biology

New Player in Alzheimer’s Disease Pathogenesis Identified

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Scientists have shown that a protein called membralin is critical for keeping Alzheimer’s disease pathology in check. The study, published in Nature Communications, shows that membralin regulates the cell’s machinery for producing beta-amyloid (or amyloid beta, Aβ), the protein that causes neurons to die in Alzheimer’s disease.

Medicine

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Alzheimer's Disease, Dementia, Aging, Drug Target, Inflammation, Biomarker

Biomarker May Predict Early Alzheimer’s Disease

Researchers at SBP have identified a peptide that could lead to the early detection of Alzheimer’s disease (AD). The discovery, published in Nature Communications, may also provide a means of homing drugs to diseased areas of the brain to treat AD, Parkinson’s disease, as well as glioblastoma, brain injuries and stroke.

Medicine

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Alzheimer's Disease, Amyloid Beta, Brain Diseases, Drug Discovery And Development, Neuroscience, Aging

How SORLA Protects Against Alzheimer’s Disease

Researchers have identified a new protective function for a brain protein genetically linked to Alzheimer’s. The findings, published in the Journal of Experimental Medicine, could inform novel treatment strategies to combat neurodegenerative diseases.

Science

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Zebrafish, rare disease, Alagille syndrome, Human Genetics

New Clues to Treat Alagille Syndrome From Zebrafish

A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) identifies potential new therapeutic avenues for patients with Alagille syndrome.

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Jamey Marth Honored for Research Linking Glycans to Diabetes, Lupus, Sepsis

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Jamey Marth, Ph.D., professor at Sanford Burnham Prebys Medical Discovery Institute (SBP), is the 2017 recipient of the Society for Glycobiology’s Karl Meyer Award. The international award is given to well-established scientists with currently active research programs who have made widely recognized major contributions to the field of glycobiology. Marth is also the Carbon Professor of Biochemistry and Molecular Biology, Mellichamp Professor of Systems Biology, and Director of the Center for Nanomedicine at UC Santa Barbara.

Medicine

Science

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SBP Medical Discovery Institute, Cancer, p62 protein, ATF4

New Insights on the Addictions of Tumors

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Stromal tissue may provide novel targets to disrupt tumor supply lines

Medicine

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Breast And Ovarian Cancer, Breast Cancer Awareness Month, Tumor Metastasis, Breast Cancer Research Foundation, Cancer Biology & Therapy, Basic Science

Fighting Against Triple-Negative Breast Cancer







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