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Medicine

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Case Western Reserve School of Medicine, Case Comprehensive Cancer Center, Oncogene, Obstetrics, Gynecology, University Hospitals, Cancer Cells, Drugs, epithelial ovarian cancer, Cancer Deaths, Women, DrugPredict, FDA-approved drugs, Aspirin, Nsaids, Ovarian Cancer, drug re-positioning, analisa difeo, rong xu, anil belur nagaraj, Pain Medications

Computer Program Finds New Uses for Old Drugs

Researchers at the Case Comprehensive Cancer Center at Case Western Reserve University School of Medicine have developed a computer program to find new indications for old drugs. The computer program, called DrugPredict, matches existing data about FDA-approved drugs to diseases, and predicts potential drug efficacy. In a recent study published in Oncogene, the researchers successfully translated DrugPredict results into the laboratory, and showed common pain medications—like aspirin—can kill patient-derived epithelial ovarian cancer cells.

Medicine

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Case Western Reserve School of Medicine, Case Western Reserve University, Department Of Defense, Orthopaedics, Biomedical Engineering, muscle stimualtion, Pressure Ulcers, Deep tissue pressure injury, increase muscle mass, kath bogie, christian zorman, douglas shire, cleveland va medical center, david keicher, integrated deposition solutions, inc., congressionally directed medical research programs, MUSCLE ATROPHY, Quality Of Life, Disabled, debilitating medical conditions, outpatient procedure

Researchers Receive DOD Grant for Implantable Muscle Stimulator

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A team of researchers led by Kath Bogie, DPhil (PhD), a biomedical engineer and associate professor of orthopaedics and biomedical engineering at Case Western Reserve University School of Medicine, and colleagues from Case Western Reserve and other institutions, has received a $1.8M, three-year grant from the U.S. Department of Defense to develop an implantable muscle stimulator for preventing pressure ulcers and deep tissue injuries to the buttocks. These serious medical conditions, which are caused by lying or sitting in one place for long periods of time, can lead to severe pain and infection, even death.

Medicine

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Case Western Reserve School of Medicine, Vanderbilt University, University Of Pittsburgh, infrared light technology, infrared neuromodulation, Cardiac Arrhythmias, High Blood Pressure, Low Blood Pressure, Asthma, Sleep Apnea, Diarrhea, Children, michael jenkins, Autonomic Nervous System, Pediatrics, Biomedical Engineering, Dehydration

Shining a Light on the Nervous System to Thwart Disease

Researchers from Case Western Reserve University School of Medicine, Vanderbilt University, and University of Pittsburgh have received a four-year, $9 million grant from the National Institutes of Health to develop enhanced infrared light technology (infrared neuromodulation) for potentially treating a variety of diseases, including cardiac arrhythmias, high and low blood pressure, asthma, sleep apnea and diarrhea, one of the leading killers of children worldwide.

Life

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Social and Behavioral Sciences

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Desire, Focus, Concentration, Psychology

New Research Finds People Will Desire Something Even More if You Increase Their Focus on It

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Study suggests ways marketing and clinical treatment can influence behavior

Medicine

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JAMA Opthalmology, jonathan lass, cornea preservation, Case Western Reserve University School Of Medicine, University Hospitals Eye Institute, NIH, NEI, corneas, Cornea preservation time study, donor corneas, Clinical Trial, corneal transplantation

New Study Offers Added Hope for Patients Awaiting Corneal Transplants

New national research led by Jonathan Lass, MD of Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center has found that corneal donor tissue can be safely stored for 11 days before transplantation surgery to correct eye problems in people with diseases of the cornea. This is four days longer than the current conventional maximum of seven days in the United States.

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Social and Behavioral Sciences

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Discrimination, Retail, Consumerism, African-American, Shopping

Racial Profiling by Retailers Creates an Unwelcome Climate for Black Shoppers, Study Shows

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Discrimination endured by black shoppers forces them to downplay their race or shy away from an activity among the most common and celebrated in American culture, according to new research.

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Uber, flying vehicles

Uber's Flying Taxis: Mechanical and Aerospace Engineering Prof Can Speak to the Media About Uber's Big Plans

Medicine

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Air Pollution, Case Western Reserve School of Medicine, University Hospitals, Asia, Sanjay Rajagopalan, Cardiovascular Medicine, face masks, Aspire, respirators, N95 respirators, China, India, Brazil, Acute Coronary Syndrome, high-pollution locales

Do Face Masks Protect Against Air Pollution-Related Health Problems?

Many people around the world, especially in Asia, wear face masks to protect against air pollution. Do they work? Sanjay Rajagopalan, MD, Herman Hellerstein, professor of cardiovascular medicine at Case Western Reserve University School of Medicine and chief of cardiovascular medicine at University Hospitals Cleveland Medical Center, has received a $2 million National Institutes of Health grant to help find out if face masks really protect against air pollution.

Medicine

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Hearing Loss, Case Western Reserve School of Medicine, USH3, Gene Therapy, Deafness, Deaf and Hard of Hearing, clarin-1, clrn1, Kumar Algramam, Lawrence Lustig, Genetics, Genomic Science, Usher Syndrome, Sensory Hair Cells, Gene Mutation, head & neck surgery, scientific reports

Case Western Reserve Research Advance May Prevent a Form of Hereditary Hearing Loss

A research advance co-led by Case Western Reserve University School of Medicine’s Kumar Alagramam, PhD, may stop the progression of hearing loss and lead to significant preservation of hearing in people with Usher syndrome type III, a form of hereditary hearing loss linked to defects in the sensory “hair” cells in the inner ear. USH3 is caused by a mutation in the clarin-1 gene.

Medicine

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Case Western Reserve School of Medicine, richard zigmond, Journal Of Neuroscience, Immune Cells, Nervous System, Nerve Regeneration, Neutrophils, Nerve Cell Damage, Chemoattractants, cxc11, cxc12, CCR2, Macrophages, jane lindborg, Neurodegenerative Disease, immunostimulant, immunodeficiencies

Researchers Find Immune Cells Help Rebuild Damaged Nerves

Immune cells are normally associated with fighting infection but in a new study, scientists have discovered how they also help the nervous system clear debris, clearing the way for nerve regeneration after injury. In a study published in the Journal of Neuroscience, researchers from Case Western Reserve University School of Medicine showed certain immune cells—neutrophils—can clean up nerve debris, while previous models have attributed nerve cell damage control to other cells entirely.







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