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Medicine

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Bidmc, Beth Israel Deaconess Medical Center, Chocolate, Dark Chocolate, Atrial Fibrillation, Heart, Heart Health, cardiovascuar health, Harvard School Of Public Health, Elizabeth Mostofsky, Murray Mittleman, Cardiovascular Benefits

Eating Chocolate May Decrease Risk of Irregular Heartbeat, Study Shows

Chocolate consumption, particularly of dark chocolate, has been linked to improvements in various indicators of heart health. This study examined the possible association between chocolate intake and a lower rate of being diagnosed with atrial fibrillation. While this is an observational study, researchers believe these findings warrant further consideration to identify effective prevention strategies for atrial fibrillation.

Science

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Beth Israel Deaconess Medical Center, Clinical Microbiology, microbioloby, Bacteria, Pathology, Brucella

Dramatic Cooperation Between Two Infectious Bacteria Revealed by BIDMC Researchers

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New methodology allowed researchers at BIDMC to more easily investigate mechanisms of infection and provide new insight into how pathogens can work together to cause disease. Using the new tool, researchers confirmed a safer model for study of Brucella species, which cause a potentially debilitating infectious disease in humans and cattle.

Medicine

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Beth Israel Deaconess Medical Center, National Academy Of Sciences Member, National Academy Of Sciences, Endocrinology, Diabetes & Endocrinology

BIDMC Scientist Barbara B. Kahn, MD, Elected to the National Academy of Sciences

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Beth Israel Deaconess Medical Center’s (BIDMC) Barbara B. Kahn, MD, an international leader in the field of diabetes, endocrinology and metabolism, has been elected to the prestigious National Academy of Sciences (NAS).

Science

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Sleep, pain, chronic sleep loss , Pain Sensitivity

To Improve Chronic Pain, Get More Sleep (Coffee Helps Too)

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New research from Beth Israel Deaconess Medical Center (BIDMC) and Boston Children’s Hospital shows that chronic sleep loss increases pain sensitivity. It suggests that chronic pain sufferers can get relief by getting more sleep, or, short of that, taking medications to promote wakefulness such as caffeine. Both approaches performed better than standard analgesics in a rigorous study in mice, described in the May 8, 2017 issue of Nature Medicine.

Medicine

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Bidmc, Beth Israel Deaconess Medical Center, Smith Center for Outcomes Research in Cardiology at BIDMC, Ethics, End Of Life, Advance Directives, Medical Decision Making

Ethics Study: Inconsistent State Laws May Complicate Medical Decision-Making

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A patchwork of state laws can make it confusing to navigate incapacitated patients’ medical wishes. Without clear national standards, the problem may worsen as the nation’s 75 million baby boomers continue to age, according to medical ethics research led by investigators at Beth Israel Deaconess Medical Center, the Mayo Clinic and the University of Chicago’s MacLean Center for Clinical Medical Ethics.

Medicine

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Bidmc, Beth Israel Deaconess Medical Center, Autism Spectrum Disorder, Autism, Sociability, Neuropathology, Neurobiology, Neuroscience

The Genes and Neural Circuits Behind Autism’s Impaired Sociability

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Researchers at Beth Israel Deaconess Medical Center (BIDMC) have gained new insight into the genetic and neuronal circuit mechanisms that may contribute to impaired sociability in some forms of Autism Spectrum Disorder.

Medicine

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Pancreas Cancer, Light, Spectroscopy, Diagnosis, Diagnosing, Minimally Invasive, Accurate

Light Scattering Spectroscopy Helps Doctors Identify Early Pancreatic Cancer

Pancreatic cancer has the lowest survival rate among all major cancers, largely because physicians lack diagnostic tools to detect the disease in its early, treatable stages. Now, a team of investigators led by Lev T. Perelman, PhD, Director of the Center for Advanced Biomedical Imaging and Photonics at Beth Israel Deaconess Medical Center (BIDMC), has developed a promising new tool capable of distinguishing between harmless pancreatic cysts and those with malignant potential with an overall accuracy of 95 percent. The team’s preliminary data was published online today in the journal Nature Biomedical Engineering.

Medicine

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Breast Cancer, triple negative breast cancer, Resistance, Chemotherapy, cobination therapy, Leflunomide

Newly Discovered Vulnerability in an Aggressive Breast Cancer Provides Therapeutic Target

• Triple-negative breast cancer quickly becomes resistant to current therapies, leaving patients no therapeutic options. • BIDMC researchers discovered that TNBC cells increase production of pyrimidine nucleotides in response to traditional chemotherapy. • Discovery represents a vulnerability that can be exploited by blocking pyrimidine using an existing inhibitor in combination with chemotherapy.

Medicine

Science

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Sleep, Neuron, Wake, wakefullness, Circadian, Narcolepsy, Caffeine, Adenosine, neuronal circuit, Brain

BIDMC Scientists Survey the State of Sleep Science

Sleep remains an enduring biological mystery with major clinical relevance, according to a review by clinician-researcher Thomas Scammell, MD, of Beth Israel Deaconess Medical Center (BIDMC) and colleagues. In recent decades, new technologies have allowed neuroscientists to identify multiple brain circuits that govern the sleep/wake cycle, as well as the factors that can influence it, such as caffeine and light. But the brain’s complexity is still a stumbling block in understanding this ubiquitous and necessary animal behavior, the researchers wrote. Their review appeared today in the journal Neuron.

Medicine

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Immunity, Immunology, Antibodies, zika, Virus, Vaccine, Birth Defect, Congenital, Dna Vaccines, Clinical Trials

Research Teams Hone in on Zika Vaccines, but Challenges Remain

As public health officials warn that spring’s warmer temperatures may herald another increase of Zika virus infections in the Caribbean and North and South America, researchers around the world are racing to develop safe and effective measures to prevent the disease. In a review paper published today in the journal Immunity, a group of leading vaccine scientists – including Dan H. Barouch, MD, PhD, of Beth Israel Deaconess Medical Center (BIDMC) – outline advances in the hunt for a Zika vaccine and the challenges that still lie ahead. “The pace of preclinical and early clinical development for Zika vaccines is unprecedented,” said Barouch, corresponding author and director of the Center for Virology and Vaccine Research at BIDMC. “In less than a year, our group and others have demonstrated that multiple vaccine platforms can provide robust protection against Zika virus challenge in animal models. However, unique challenges will need to be addressed in the clinical development of a Zi







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