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Length of Opioid Prescription, Number of Refills Spell Highest Risk for Misuse After Surgery

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With opioid overdoses now a leading cause of nonintentional death in the United States, data show most of these deaths can be traced back to an initial prescription opioid. A new study led by investigators at Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical School (HMS) sheds light on the possible link between physicians’ opioid prescription patterns and subsequent abuse.

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Non-Coding RNA Precision Diagnostics and Therapeutics Core Facility Opens at Beth Israel Deaconess Medical Center

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The Cancer Center and the Department of Pathology at Beth Israel Deaconess Medical Center (BIDMC) has opened a new state-of-the-art facility dedicated to the study of non-coding RNAs (ncRNA). The Non-Coding RNA Precision Diagnostics and Therapeutics Core Facility will help accelerate the discovery and translation of ncRNA diagnostics and therapeutics, with the hope of leading to better cures and treatments for disease

Medicine

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Beth Israel Deaconess Medical Center, Pier Paolo Pandolfi, Ming Chen

Flipping the Switch: Dietary Fat, Changes in Fat Metabolism May Promote Prostate Cancer Metastasis

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Prostate tumors tend to be what scientists call “indolent” – so slow-growing and self-contained that many affected men die with prostate cancer, not of it. But for the percentage of men whose prostate tumors metastasize, the disease is invariably fatal. In a set of papers out today in the journals Nature Genetics and Nature Communications, researchers at the Cancer Center at Beth Israel Deaconess Medical Center (BIDMC) shed new light on the genetic mechanisms that promote metastasis in the mouse model and also implicated the typical Western high-fat diet as a key environmental factor driving metastasis.

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Cancer’s Gene-Determined “Immune Landscape” Dictates Progression of Prostate Tumors

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The field of immunotherapy – the harnessing of patients’ own immune systems to fend off cancer – is revolutionizing cancer treatment today. However, clinical trials often show marked improvements in only small subsets of patients, suggesting that as-yet unidentified variations among tumors result in distinct paths of disease progression and response to therapy.

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Beth Israel Deaconess Medical Center, Michael Fox, Richard Darby

Can Brain Lesions Contribute to Criminal Behavior?

New research published in the Proceedings of the National Academy of Sciences indicates that lesions to brain areas in individuals exhibiting criminal behavior all fall within a particular brain network involved in moral decision-making.

Medicine

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James Kirby, Beth Israel Deaconess Medical Center

BIDMC Researchers Use Artificial Intelligence to Identify Bacteria Quickly and Accurately

Microscopes enhanced with artificial intelligence (AI) could help clinical microbiologists diagnose potentially deadly blood infections and improve patients’ odds of survival, according to microbiologists at Beth Israel Deaconess Medical Center (BIDMC).

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Beth Israel Deaconess Medical Center, Dan Barouch, zika

Zika Vaccine Induces Robust Immune Responses in Three Phase 1 Trials

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Healthy adults mounted strong immune responses after receiving an investigational whole inactivated Zika virus vaccine, according to interim analyses of three Phase 1, placebo-controlled, double-blind trials conducted at Beth Israel Deaconess Medical Center (BIDMC), Walter Reed Army Institute of Research (WRAIR), and Saint Louis University School of Medicine. The findings were published today in The Lancet.

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Beth Israel Deaconess Medical Center, Robert Yeh, Eric A. Secemsky

Study Finds More Than 1 in 6 Patients With Peripheral Arterial Disease Who Undergo Revascularization Readmitted Within 30 Days

Led by researchers in the Smith Center for Outcomes Research in Cardiology at Beth Israel Deaconess Medical Center (BIDMC), the large-scale analysis determined that 30 percent of readmissions following peripheral revascularization were related to complications associated with the procedure, while differences in hospital quality accounted only modestly for readmission risk.

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Beth Israel Deaconess Medical Center, Richard L. Haspel, MD, PhD

New Adaptable Medicine Curriculum Offers Health Care Providers “Universal” Genomics Education

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The Universal Genomics Instructor Handbook and Toolkit, a new, free educational resource designed to educate clinicians in all medical specialties in genomic medicine, is now available to improve physician genomic education worldwide. Developed by a team led by Richard L. Haspel, MD, PhD, Pathologist at Beth Israel Deaconess Medical Center (BIDMC) and Associate Professor of Pathology at Harvard Medical School, the handbook and accompanying online toolkit were developed through funding from The National Human Genome Research Institute (NHGRI), one of the 27 institutes and centers at the National Institute of Health.

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Beth Israel Deaconess Medical Center, Dipak Panigrahy, Cancer

Double-Edged Sword: Killing Cancer Cells can also Drive Tumor Growth

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Cancer therapies including radiation and chemotherapy seek to treat the disease by killing tumor cells. Now a team including researchers at Beth Israel Deaconess Medical Center (BIDMC) have shown that the dead and dying cancer cells generated by chemotherapy and targeted cancer therapy paradoxically trigger inflammation that promotes aggressive tumor growth. In a study published today in the Journal of Experimental Medicine, the team has illuminated the mechanism by which tumor cell death can drive primary tumor growth and metastasis.







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