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Medicine

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Asthma, Food Allergy, Amplifier, allergy treatment, Histamine

Allergy Amplifier Implicated in Asthma Also Intensifies Food Allergy

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In 2012, LJI researcher Toshiaki Kawakami, M.D., Ph.D., reported that a small protein aptly named histamine-releasing factor (HRF) played a pro-inflammatory role in asthma. The current paper reports a novel biochemical mechanism governing HRF activity, paves the way for blood tests to predict which patients will respond to allergy therapy, and strongly supports the idea that drugs designed to block HRF could prevent food allergy attacks.

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Dengue Immunity Can Protect Against Zika Virus

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A study by LJI researcher Dr. Sujan Shresta reports that mice rendered immune to dengue show "cross-protection" from subsequent Zika infection and then identifies specific types of immune T-cells capable of defending against both viruses. These revelations have profound implications for efforts to build a potent anti-Zika vaccine.

Science

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La Jolla Institute for Allergy and Immunology, Cancer, Inflammatory Disease

No Longer Lost in Translation

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Mouse models have advanced our understanding of immune function and disease in many ways but they have failed to account for the natural diversity in human immune responses. As a result, insights gained in the lab may be lost in translation. In their latest study, researchers at La Jolla Institute for Allergy and Immunology, developed a new approach to model human immune variation in the lab that overcomes the limitations of traditional mouse models.

Medicine

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Dr. Crotty , La Jolla Institute , HIV, Hiv Vaccine, La Jolla Institute for Allergy and Immunology

San Diego Team Tests Best Delivery Mode for Potential HIV Vaccine

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For decades, HIV has successfully evaded all efforts to create an effective vaccine but researchers at The Scripps Research Institute (TSRI) and the La Jolla Institute for Allergy and Immunology (LJI) are steadily inching closer. Their latest study, published in the current issue of Immunity, demonstrates that optimizing the mode and timing of vaccine delivery is crucial to inducing a protective immune response in a preclinical model.

Medicine

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La Jolla Institute for Allergy and Immunology, Professor Pandurangan Vijayanand, Cancer Research, Cancer Researc, T Cells, memory cells

Tumor Immune Fitness Determines Survival of Lung Cancer Patient

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In recent years, immunotherapy, a new form of cancer therapy that rouses the immune system to attack tumor cells, has captivated the public’s imagination. When it works, the results are breathtaking. But more often than not it doesn’t, and scientists still don’t know why.

Medicine

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La Jolla Institute for Allergy and Immunology

TWEAKing Inflammation

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Superficially, psoriasis and atopic dermatitis may appear similar but their commonalities are only skin deep. Atopic dermatitis, also known as eczema, is primarily driven by an allergic reaction, while psoriasis is considered an autoimmune disease. Nevertheless, researchers at La Jolla Institute for Allergy and Immunology were able to pinpoint a common driver of skin inflammation in both diseases.

Business

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La Jolla Institute for Allergy and Immunology

LJI Professor Klaus Ley Wins Prestigious National Award

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Professor Klaus Ley, M.D., has been selected as this year’s winner of the Eugene M. Landis Award, the Microcirculatory Society’s top honor, in recognition of his pioneering work in vascular biology and microcirculation. The microcirculation comprises all the small blood vessels in all tissues and organs and their contents (blood plasma and blood cells).

Medicine

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La Jolla Institute for Allergy and Immunology, Dr. Sette

LJI Research Lab Wins Best Academic Research Team Award

Dr. Alessandro Sette’s team at La Jolla Institute for Allergy and Immunology has been named Best Academic Research Team as part of the 10th Vaccine Industry Excellence Awards at this year’s World Vaccine Congress 2017 held in Washington. The ViE Awards celebrate the outstanding contributions and achievements of leaders who continually set standards of excellence and advocacy in vaccine development.

Medicine

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La Jolla Institute for Allergy and Immunology, T Cells, Cancer Research, LJI

The Molecular Underpinnings of T Cell Exhaustion

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One reason we survive into adulthood is that cell-killing T cells usually recognize and eliminate cancerous or pathogen-infected cells. But prolonged overactivity of immune cells summoned to a tumor or infection site can render them useless to dispatch invaders, a cellular state immunologists call "exhaustion." Fortunately, cancer researchers are devising effective immunotherapies to counter exhaustion and re-motivate immune cells to eradicate a patient's tumor

Medicine

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zika, La Jolla Institute for Allergy and Immunology, Sujan Shresta, LJI, Dengue, T Cell

Pre-Existing Immunity to Dengue Virus Shapes Zika-Specific T Cell Response

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Although Zika and dengue are considered different virus “species,” they are so closely related that the immune system treats Zika just like another version of dengue, report researchers at La Jolla Institute for Allergy and Immunology. Their latest study, published in the March 13, 2017, advance online edition of Nature Microbiology, shows that pre-existing immunity to dengue virus modulates the magnitude and breadth of the immune system’s T cell response to Zika.







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