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Article ID: 692704

LJI Researchers Are One Step Closer to an Effective Anti-Atherosclerosis Vaccine

La Jolla Institute for Allergy and Immunology

A new paper published in Circulation by researchers at La Jolla Institute for Allergy and Immunology reports successful vaccination of atherosclerotic mice with a small chunk of protein snipped out of "bad cholesterol." Vaccination reduced plaque levels in test mice, and other experiments with human blood samples identified the class of T cells likely responsible for positive outcomes. The paper suggests that a comparable strategy could form the basis of a human vaccine.

Released:
12-Apr-2018 12:05 PM EDT
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    23-Mar-2018 2:00 PM EDT

Article ID: 691349

Bystander T Cells Can Steal the Show From "Professional" Regulatory Cells in Resolving Inflammation

La Jolla Institute for Allergy and Immunology

A team led by LJI researchers reveals that bystander cell accumulation antagonizes rather than abets cell-killing by specific CTLs, curbing inflammation. This is noteworthy because that chief anti-inflammatory role has been traditionally ascribed to what are called regulatory T cells, or "Tregs", which dampen autoimmune responses. T

Released:
19-Mar-2018 11:05 AM EDT
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Article ID: 691491

Western Diet Depletes Artery-Protecting Immune Cells

La Jolla Institute for Allergy and Immunology

New research from scientists at the La Jolla Institute for Allergy and Immunology shows how a diet high in fat and cholesterol depletes the ranks of artery-protecting immune cells, turning them into promoters of inflammation, which exacerbate atherosclerotic plaque buildup that occurs in cardiovascular disease. The team has also found that high density lipoproteins (HDL)—more commonly known as “good cholesterol”—counteract this process, helping the protective immune cells maintain their identity and keep arteries clear.

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20-Mar-2018 6:05 PM EDT
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Article ID: 689681

Immune Signature Predicts Asthma Susceptibility

La Jolla Institute for Allergy and Immunology

Asthma is a chronic inflammatory disease driven by the interplay of genetics, environmental factors and a diverse cast of immune cells. In their latest study, researchers at La Jolla Institute for Allergy and Immunology (LJI) identified a subset of T cells, whose frequency serves as early childhood immune signature that predicts the risk of developing asthma later on.

Released:
16-Feb-2018 10:05 AM EST
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    13-Feb-2018 12:00 PM EST

Article ID: 689241

LJI researchers reveal how to undermine immune cell mobilization in allergic inflammation.

La Jolla Institute for Allergy and Immunology

LJI researchers report mechanisms used by a subgroup of ILCs, known as ILC2 cells, to undergo maturation required for them to mount an effective immune response. These discoveries suggest a novel approach to treat inflammatory disease caused by overactive ILC2s.

Released:
9-Feb-2018 11:05 AM EST
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Article ID: 688331

Groundbreaking Parkinson’s Research at La Jolla Institute Funded by Michael J. Fox Foundation

La Jolla Institute for Allergy and Immunology

La Jolla Institute Professor Dr. Alessandro Sette has been awarded a $340,000 grant by The Michael J. Fox Foundation for Parkinson’s Research (MJFF) to follow up on an earlier MJFF-supported study, which provided the strongest evidence to date that autoimmunity plays a role in Parkinson’s disease.

Released:
23-Jan-2018 11:05 AM EST
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    19-Jan-2018 2:00 PM EST

Article ID: 688010

Novel Genomic Tools Provide New Insight Into Human Immune System

La Jolla Institute for Allergy and Immunology

La Jolla Institute scientists provide new insights into how so-called CD4 cytotoxic T cells arise in humans and thus could facilitate improved vaccine design.

Released:
19-Jan-2018 2:00 PM EST
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Article ID: 688011

LJI Researchers Discover Key Driver of Atopic Dermatitis

La Jolla Institute for Allergy and Immunology

La Jolla Institute scientists demonstrate that LIGHT, a member of the tumor necrosis factor (TNF) super family, directly controls the hyperproliferation of keratinocytes as well as the expression of periostin, a protein that contributes to the clinical features of atopic dermatitis as well as other inflammatory skin diseases such as scleroderma.

Released:
16-Jan-2018 5:05 PM EST
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    26-Dec-2017 12:00 PM EST

Article ID: 687081

One in a Million

La Jolla Institute for Allergy and Immunology

The development of an HIV vaccine has proven extraordinarily difficult. One of the reasons is that naïve precursor B cells that can give rise to mature B cells producing broadly neutralizing antibodies are exceedingly rare within the average human. Yet, despite their low frequency these B cell precursors can outcompete their B cell competitors under the right conditions.

Released:
20-Dec-2017 12:00 AM EST
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  • Embargo expired:
    26-Dec-2017 12:00 PM EST

Article ID: 687084

LJI Researchers Report How T Cells Navigate the Rough-and-Tumble Environment of the Bloodstream

La Jolla Institute for Allergy and Immunology

Helper T cells move toward inflamed tissue using membrane protrusions that stabilize them and provide traction on the vasculature. Using high-resolution microscopy and global molecular analysis, the team shows that immature T cells lack these protrusions but that maturing T-cells switch on a gene expression program to create material to construct them.

Released:
20-Dec-2017 12:05 PM EST
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