Latest News

Add to Favorites | Subscribe | Share

Filters:

  • (Press "esc" to clear)

Medicine

Science

Channels:

cytotoxic T lymphocytes, Cd4 Cells, Immune System

Novel Genomic Tools Provide New Insight Into Human Immune System

shutterstock_428705887.jpg

La Jolla Institute scientists provide new insights into how so-called CD4 cytotoxic T cells arise in humans and thus could facilitate improved vaccine design.

Medicine

Channels:

Atopic Dermatitis, Light, TNF super family, Fibrosis

LJI Researchers Discover Key Driver of Atopic Dermatitis

Periostin.png

La Jolla Institute scientists demonstrate that LIGHT, a member of the tumor necrosis factor (TNF) super family, directly controls the hyperproliferation of keratinocytes as well as the expression of periostin, a protein that contributes to the clinical features of atopic dermatitis as well as other inflammatory skin diseases such as scleroderma.

Science

Channels:

HIV, Hiv Vaccine, Chavi, Antibody, somatic hypermutation, VRC01, La Jolla Institute for Allergy and Immunology

One in a Million

Abbott_large.jpg

The development of an HIV vaccine has proven extraordinarily difficult. One of the reasons is that naïve precursor B cells that can give rise to mature B cells producing broadly neutralizing antibodies are exceedingly rare within the average human. Yet, despite their low frequency these B cell precursors can outcompete their B cell competitors under the right conditions.

Science

Channels:

Helper T Cells, slings and tethers, Inflammation, T Cell Acute Lymphoblastic Leukemia, Autoimmune Disease

LJI Researchers Report How T Cells Navigate the Rough-and-Tumble Environment of the Bloodstream

Tcelltether.png

Helper T cells move toward inflamed tissue using membrane protrusions that stabilize them and provide traction on the vasculature. Using high-resolution microscopy and global molecular analysis, the team shows that immature T cells lack these protrusions but that maturing T-cells switch on a gene expression program to create material to construct them.

Medicine

Channels:

Asthma, PrecISE Clinical Center

San Diego Team Wins $ 6.9 Million Grant to Establish PrecISE Network Clinical Center

Drs.Akuthota-Vijayanand_Jain.png

A team of physicians, scientists and biostatisticians from La Jolla Institute for Allergy and Immunology and UC San Diego School of Medicine joined forces across institutions to successfully compete for an $6.9 million grant to establish one of only 10 PrecISE Network Clinical Centers nationwide.

Medicine

Channels:

Asthma, Food Allergy, Amplifier, allergy treatment, Histamine

Allergy Amplifier Implicated in Asthma Also Intensifies Food Allergy

Mastcell.jpg

In 2012, LJI researcher Toshiaki Kawakami, M.D., Ph.D., reported that a small protein aptly named histamine-releasing factor (HRF) played a pro-inflammatory role in asthma. The current paper reports a novel biochemical mechanism governing HRF activity, paves the way for blood tests to predict which patients will respond to allergy therapy, and strongly supports the idea that drugs designed to block HRF could prevent food allergy attacks.

Medicine

Channels:

Dengue Immunity Can Protect Against Zika Virus

ZikaandDengue_overlap9.30.png

A study by LJI researcher Dr. Sujan Shresta reports that mice rendered immune to dengue show "cross-protection" from subsequent Zika infection and then identifies specific types of immune T-cells capable of defending against both viruses. These revelations have profound implications for efforts to build a potent anti-Zika vaccine.

Science

Channels:

La Jolla Institute for Allergy and Immunology, Cancer, Inflammatory Disease

No Longer Lost in Translation

shutterstock_416173357.jpg

Mouse models have advanced our understanding of immune function and disease in many ways but they have failed to account for the natural diversity in human immune responses. As a result, insights gained in the lab may be lost in translation. In their latest study, researchers at La Jolla Institute for Allergy and Immunology, developed a new approach to model human immune variation in the lab that overcomes the limitations of traditional mouse models.

Medicine

Channels:

Dr. Crotty , La Jolla Institute , HIV, Hiv Vaccine, La Jolla Institute for Allergy and Immunology

San Diego Team Tests Best Delivery Mode for Potential HIV Vaccine

HIVspikes1jr.jpg

For decades, HIV has successfully evaded all efforts to create an effective vaccine but researchers at The Scripps Research Institute (TSRI) and the La Jolla Institute for Allergy and Immunology (LJI) are steadily inching closer. Their latest study, published in the current issue of Immunity, demonstrates that optimizing the mode and timing of vaccine delivery is crucial to inducing a protective immune response in a preclinical model.

Medicine

Channels:

La Jolla Institute for Allergy and Immunology, Professor Pandurangan Vijayanand, Cancer Research, Cancer Researc, T Cells, memory cells

Tumor Immune Fitness Determines Survival of Lung Cancer Patient

tumor_infiltrating_T_cells.jpg

In recent years, immunotherapy, a new form of cancer therapy that rouses the immune system to attack tumor cells, has captivated the public’s imagination. When it works, the results are breathtaking. But more often than not it doesn’t, and scientists still don’t know why.







Chat now!