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Deadly Lung Cancers Are Driven by Multiple Genetic Changes

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A new UC San Francisco–led study challenges the dogma in oncology that most cancers are caused by one dominant “driver” mutation that can be treated in isolation with a single targeted drug.

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Fertility, Chemotherapy

Breast Cancer Patients Who Freeze Their Eggs See No Delay for Chemotherapy

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Women who receive a breast cancer diagnosis while they are still young enough to bear children can take time to freeze their eggs and embryos without fear of delaying their cancer treatment, according to research by UC San Francisco scientists who have helped develop a faster fertility preservation technique that can achieve in two weeks what used to take a month or longer.

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University of California Cancer Consortium Takes on California’s $14 Billion Killer

The University of California’s five academic cancer centers, home to some of the world’s leading scientists and physicians, have formed a consortium to better address California’s most pressing cancer-related problems and opportunities, UC President Janet Napolitano and Dr. John Stobo, executive vice president of UC Health, announced today.

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Big-Data Analysis Points Toward New Drug Discovery Method

A research team led by scientists at UC San Francisco has developed a computational method to systematically probe massive amounts of open-access data to discover new ways to use drugs, including some that have already been approved for other uses.

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Colon, Colorectal Cancer, Survivorship, Recurrence, Diet, Exercise, Prevention, Cancer, Body Weight, BMI

Eating Right and Exercising Could Reduce the Risk of Colon Cancer Recurrence

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Colon cancer patients who have a healthy body weight, exercise regularly and eat a diet high in whole grains, fruits and vegetables have a significantly lower risk of cancer recurrence or death, according to a research team led by UC San Francisco investigators. This finding represents an analysis of data collected on patients participating in a national study for people with stage III colon cancer.

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Quest for Balance in Radiation Leads to Lower Doses

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New UC Project Finds Roadmap to Improve Patient Safety in Radiation Exposure

Medicine

Science

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Cancer, drug resp

Genetic ‘Balance’ May Influence Response to Cancer Treatment

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Choosing among cancer treatments increasingly involves determining whether tumor cells harbor specific, mutated “oncogenes” that drive abnormal growth and that may also be especially vulnerable or resistant to particular drugs. But according to a new study led by UCSF researchers, in the case of the most commonly mutated cancer-driving oncogene, called KRAS (pronounced “kay-rass”), response to treatment can change as tumors evolve, either when a normal copy of the gene from the other member of the matched chromosome pair is lost, or when the cancers cells evolve to produce additional copies of the mutated form of the gene.

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Breast Cancer, hair loss during treatment

Scalp Cooling Can Help Some Breast Cancer Patients Retain Hair

Scalp cooling can lessen some chemotherapy-induced hair loss – one of the most devastating hallmarks of cancer – in certain breast cancer patients, according to a new multicenter study from UC San Francisco, Weill Cornell Medicine and three other medical centers.   A majority of the study’s patients, all women with stage 1 or 2 breast cancer who underwent scalp cooling, retained more than half of their hair after completing chemotherapy, the investigators learned.

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Breast Cancer, estrogen receptor positive breast cancer, Estrogen Receptor Positive, peri-menopause, Premenopause, Breast Cancer Risk, Weight, Obesity, Cancer

The Role of Common Risk Factors in ER-Positive, ER-Negative Breast Cancer

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Karla Kerlikowske, MD, and team recently published a paper in the Journal of the National Cancer Institute that examined the role of common risk factors in the development of ER-positive and ER-negative breast cancers. The study sheds new light on how a woman’s age, weight, and menopausal status affect her risk for breast cancer. Dr. Kerlikowske discusses the findings below.

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Cancer, Public Health, Population And Public Health, Prevention, Screening, Tobacco Related Illnesses, Lung Cancer, Liver Cancer, Prostate Cancer, Breast Cancer, Colorectal Cancer, Colon Cancer, Hepatitis B, Hepatitis C, Smoking Cessation, Cancer Prevention and Control

Broad New Partnership Launches Plan to Reduce Cancer in San Francisco

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Cancer is the leading cause of death in San Francisco and costs patients, families and taxpayers hundreds of millions of dollars each year. Seeing an opportunity to change this, a group that includes UC San Francisco (UCSF), the City and County of San Francisco, the San Francisco Department of Public Health (DPH), and health care and community organizations has launched the San Francisco Cancer Initiative (SF CAN), a major public health effort to reduce cancer in San Francisco.


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