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Released: 5-Oct-2022 2:05 PM EDT
HHMI Investigator Carolyn Bertozzi Awarded the 2022 Nobel Prize in Chemistry
Howard Hughes Medical Institute (HHMI)

The Royal Swedish Academy of Sciences announced today that HHMI Investigator Carolyn Bertozzi of Stanford University, Morten Meldal of University of Copenhagen, and K. Barry Sharpless of Scripps Research Institute are the recipients of the 2022 Nobel Prize in Chemistry for the development of click chemistry and bioorthogonal chemistry.

Released: 7-Sep-2022 2:05 PM EDT
How Fat Signals Us to Eat More of It
Howard Hughes Medical Institute (HHMI)

Scientists discover how fat triggers a gut-to-brain mechanism that drives us to keep consuming more of it. Their findings could one day lead to interventions to help treat obesity and associated disorders.

Released: 2-Sep-2022 2:05 PM EDT
Ancient DNA Offers New Insights into the Origins and Spread of Languages and Populations Across the Southern Arc
Howard Hughes Medical Institute (HHMI)

Analyzing DNA from the remains of hundreds of ancient humans across West Asia, the Balkans, Greece, present-day Turkey, and other regions, scientists have revealed surprising migrations that illuminate human history and led to the languages billions of people speak today.

Released: 1-Sep-2022 2:05 PM EDT
Blanton Tolbert Named HHMI’s Inaugural Vice President of Science Leadership and Culture
Howard Hughes Medical Institute (HHMI)

Blanton Tolbert, a biochemist and administrative leader of diversity, equity, and inclusion efforts at Case Western Reserve University, will serve as an HHMI vice president and head of the Institute’s new Center for Science Leadership and Culture.

Newswise: New HHMI Program Pledges $1.5 Billion for Outstanding Early Career Faculty Committed to Diversity, Equity, and Inclusion
Released: 26-May-2022 6:00 AM EDT
New HHMI Program Pledges $1.5 Billion for Outstanding Early Career Faculty Committed to Diversity, Equity, and Inclusion
Howard Hughes Medical Institute (HHMI)

The Freeman Hrabowski Scholars Program will support up to 150 early career scientists for their research and their efforts to create labs in which everyone can thrive. Applications to the program are open now.

Newswise: After More than 20 Years, Scientists Have Solved the Full-Length Structure of a Janus Kinase
8-Mar-2022 2:25 PM EST
After More than 20 Years, Scientists Have Solved the Full-Length Structure of a Janus Kinase
Howard Hughes Medical Institute (HHMI)

More than two decades of effort went into a project that has now revealed the structure of a crucial signaling molecule, opening the door to new and better drugs for some cancers.

Newswise: When Ribosomes Collide: How Bacteria Clean Up After Molecular Crashes
4-Mar-2022 3:55 PM EST
When Ribosomes Collide: How Bacteria Clean Up After Molecular Crashes
Howard Hughes Medical Institute (HHMI)

Tiny cellular machines called ribosomes build proteins. When this building process goes awry in bacteria, ribosomes collide, triggering the arrival of a first responder molecule that begins a rescue operation.

18-Feb-2022 12:55 PM EST
How Some Gut Microbes Awaken Zombie Viruses in Their Neighbors
Howard Hughes Medical Institute (HHMI)

Gut bacteria brew all sorts of chemicals, but we don’t know what most of them do. A new study suggests that one such compound, previously linked to cancer, may serve as a bizarre weapon in microbial skirmishes.

Newswise:Video Embedded these-scientists-are-racing-to-beat-omicron
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Released: 21-Jan-2022 1:05 PM EST
These Scientists Are Racing to Beat Omicron
Howard Hughes Medical Institute (HHMI)

As teams of researchers around the world race to piece together a picture of the Omicron variant, they’re fast-tracking discoveries and transforming the way science is done.

21-Sep-2021 2:35 PM EDT
HHMI Invests $300 Million in 33 New Investigators
Howard Hughes Medical Institute (HHMI)

The scientists come from 21 US institutions and will join a community of Investigators who are tackling some of the most challenging problems in biomedical research.

17-Jun-2021 2:00 PM EDT
Leopard Gecko Skin Tumors Traced to Cancer Gene
Howard Hughes Medical Institute (HHMI)

In a rare gecko color variety known as Lemon Frost, scientists have traced an unusual coloring and tendency to form tumors to a gene linked to human melanoma.

   
24-Feb-2021 10:20 AM EST
Here’s How Insects Coax Plants into Making Galls
Howard Hughes Medical Institute (HHMI)

Scientists have identified proteins in aphid saliva that can alter plant development. These proteins drive abnormal growths called galls, which give insects a protected place to feed and reproduce.

16-Feb-2021 11:30 AM EST
HHMI Commits $30 Million to Increase Diversity in Science with 21 Hanna Gray Fellows
Howard Hughes Medical Institute (HHMI)

HHMI announces the selection of 21 exceptional early career scientists as 2020 Hanna Gray Fellows to support diversity in biomedical research. The 2022 Hanna H. Gray Fellows Program competition will open later this year.

20-Nov-2020 10:15 AM EST
Recording the Symphony of Cellular Signals That Drive Biology
Howard Hughes Medical Institute (HHMI)

Like a computer, cells must process information from the outside world before they respond. Scientists have now developed a powerful new way to observe the internal discussions responsible for cellular decisions.

Released: 11-Nov-2020 4:10 PM EST
COVID-19 Immunity May Last Six Months or More
Howard Hughes Medical Institute (HHMI)

People who have recovered from coronavirus can make potent antibodies to SARS-CoV-2 that evolve in the months after infection. These antibodies may be evolving in response to residual viral antigen hidden in the gut.

Released: 12-Oct-2020 3:30 PM EDT
Jennifer Doudna Awarded 2020 Nobel Prize in Chemistry
Howard Hughes Medical Institute (HHMI)

The Royal Swedish Academy of Sciences announced today that Howard Hughes Medical Institute (HHMI) Investigator Jennifer Doudna of University of California, Berkeley, and Emmanuelle Charpentier of the Max Planck Unit for the Science of Pathogens are the recipients of the 2020 Nobel Prize in Chemistry for the development of a method for genome editing.

Released: 24-Sep-2020 3:25 PM EDT
Some Severe COVID-19 Cases Linked to Genetic Mutations or Antibodies that Attack the Body
Howard Hughes Medical Institute (HHMI)

Two new studies offer an explanation for why COVID-19 cases can be so variable. A subset of patients has mutations in key immunity genes; other patients have auto-antibodies that target the same components of the immune system. Both circumstances could contribute to severe forms of the disease.

12-Jun-2020 1:05 PM EDT
Tomato’s Hidden Mutations Revealed in Study of 100 Varieties
Howard Hughes Medical Institute (HHMI)

A new analysis of difficult-to-access genetic variation is the most comprehensive ever conducted in plants. It could guide the improvement of tomatoes and other crops.

Released: 22-May-2020 1:05 PM EDT
Preventing ‘Cytokine Storm’ May Ease Severe COVID-19 Symptoms
Howard Hughes Medical Institute (HHMI)

A clinical trial in people with the new coronavirus is testing a drug that may halt an overactive immune response before it ramps up.

Released: 12-May-2020 12:35 PM EDT
SARS-CoV-2 Targets Many Cell Types, Analysis of Single-Cell Data Suggests
Howard Hughes Medical Institute (HHMI)

The new coronavirus invades cells that sport certain molecules on their surfaces. A network of researchers realized they already had the data to identify these cells.

27-Apr-2020 3:45 PM EDT
Clayton S. Rose Elected Chair of HHMI’s Trustees
Howard Hughes Medical Institute (HHMI)

Rose, President of Bowdoin College and a longtime Howard Hughes Medical Institute Trustee, will succeed Kurt L. Schmoke as Chair of the Trustees.

Released: 27-Apr-2020 4:50 PM EDT
Tracking the COVID-19 Pandemic with an App
Howard Hughes Medical Institute (HHMI)

Researchers and a volunteer team from Pinterest developed How We Feel, an app that lets users report symptoms of the disease caused by the novel coronavirus.

   
10-Apr-2020 1:30 PM EDT
A Gut-to-Brain Circuit Drives Sugar Preference and May Explain Sugar Cravings
Howard Hughes Medical Institute (HHMI)

The sensation of sweetness starts on the tongue, but sugar molecules also trip sensors in the gut that directly signal the brain. This could explain why artificial sweeteners fail to satisfy the insatiable craving for sugar.

   
Released: 8-Apr-2020 9:00 AM EDT
Repurposing Existing Drugs Could Offer Faster Path to COVID-19 Treatment
Howard Hughes Medical Institute (HHMI)

A map of interactions between the novel coronavirus and human proteins is helping scientists identify drugs that might work as therapeutics.

   
Released: 31-Mar-2020 11:50 AM EDT
Virus-Scanning Tool Could Detect Previous COVID-19 Infections and Inform Vaccine Development
Howard Hughes Medical Institute (HHMI)

Using a research assay called VirScan, scientists plan to study how antibodies from people who have had COVID-19 attack the virus that causes it.

   
Released: 27-Mar-2020 9:00 AM EDT
Citizen Scientists Are Helping Researchers Design New Drugs to Combat COVID-19
Howard Hughes Medical Institute (HHMI)

Using a free computer game called Foldit, researchers are enlisting the help of citizen scientists to design drugs that could stop the novel coronavirus from infecting human cells.

   
Released: 25-Mar-2020 9:35 AM EDT
Patients with Severe Forms of Coronavirus Disease Could Offer Clues to Treatment
Howard Hughes Medical Institute (HHMI)

A new international project aims to enroll 500 COVID-19 patients to search for genetic mutations that make some people more vulnerable to severe infection.

Released: 6-Mar-2020 11:35 AM EST
Resurrecting Ancient Protein Partners Reveals Origin of Protein Regulation
Howard Hughes Medical Institute (HHMI)

After reconstructing the ancient forms of two cellular proteins, scientists discovered the earliest known instance of a complex form of protein regulation.

11-Sep-2019 1:05 PM EDT
HHMI Awards $1.4 Million Each to 15 Hanna Gray Fellows to Support Diversity in Science
Howard Hughes Medical Institute (HHMI)

HHMI announces the selection of 15 exceptional early career scientists as 2019 HHMI Hanna Gray Fellows to support diversity in biomedical research. The 2020 Hanna H. Gray Fellows Program competition is now open. Applications are due on January 8, 2020.

   
19-Jun-2019 12:05 PM EDT
“DNA Microscopy” Offers Entirely New Way to Image Cells
Howard Hughes Medical Institute (HHMI)

Rather than relying on optics, the microscopy system offers a chemically encoded way to map biomolecules’ relative positions.

Released: 1-May-2019 4:05 PM EDT
HHMI Announces $30 Million Science Education Initiative
Howard Hughes Medical Institute (HHMI)

HHMI's third competition for the Inclusive Excellence initiative will award grants to up to 30 schools to help increase their capacity to include students of diverse backgrounds in science.

Released: 19-Apr-2019 12:05 PM EDT
How Penicillin Acts Like TNT for Bacteria
Howard Hughes Medical Institute (HHMI)

Although penicillin was discovered nearly a century ago, scientists are still learning how the drug makes bacterial cells pop like overfilled balloons.

Released: 21-Feb-2019 2:05 PM EST
Ron Vale Named Next Executive Director of Janelia Research Campus and HHMI Vice President
Howard Hughes Medical Institute (HHMI)

Vale, an HHMI investigator at the University of California, San Francisco, will serve as the second executive director of the Ashburn, Virginia-based biomedical research center.

29-Jan-2019 9:50 AM EST
HIV Hidden in Patients’ Cells Can Now Be Accurately Measured
Howard Hughes Medical Institute (HHMI)

Until now, researchers haven’t been able to accurately quantify a latent form of HIV that persists in patients’ immune cells. A new genetic technique is fast and 10 to 100 times more accurate than previous diagnostics.

14-Jan-2019 10:05 AM EST
How to Rapidly Image Entire Brains at Nanoscale Resolution
Howard Hughes Medical Institute (HHMI)

A powerful new technique combines expansion microscopy with lattice light-sheet microscopy for nanoscale imaging of fly and mouse neuronal circuits and their molecular constituents that’s roughly 1,000 times faster than other methods.

Released: 17-Dec-2018 12:05 PM EST
Clovis People Spread to Central and South America, then Vanished
Howard Hughes Medical Institute (HHMI)

Scientists have found DNA evidence for the southward migration of the people who spread the so-called Clovis culture of North America. But starting about 9,000 years ago, these people were replaced by a distinct population.

29-Oct-2018 3:15 PM EDT
Decoding How Brain Circuits Control Behavior
Howard Hughes Medical Institute (HHMI)

Janelia and Allen Institute scientists team up, combining genetic analyses, anatomical maps, and detailed studies of neuronal activity to reveal brain cells’ roles in controlling movement.

15-Oct-2018 10:05 AM EDT
Vast Leukemia Dataset Could Help Researchers Match Therapies to Patients
Howard Hughes Medical Institute (HHMI)

Data on the molecular makeup and drug sensitivity of hundreds of patient samples could accelerate progress against the aggressive blood cancer acute myeloid leukemia.

   
4-Oct-2018 12:05 PM EDT
New Microscope Offers 4-D Look at Embryonic Development in Living Mice
Howard Hughes Medical Institute (HHMI)

With the development of an adaptive, multi-view light sheet microscope and a suite of computational tools, researchers have captured the first view of early organ development inside the mouse embryo.

   
Released: 1-Oct-2018 11:00 AM EDT
This Wild Plant Could be the Next Strawberry
Howard Hughes Medical Institute (HHMI)

By combining genomics and gene editing, researchers have figured out how to rapidly bring a plant known as the groundcherry toward domestication.

Released: 12-Sep-2018 9:20 AM EDT
HHMI Awards Hanna Gray Fellowships to 15 Early Career Scientists
Howard Hughes Medical Institute (HHMI)

HHMI announces the selection of 15 exceptional early career scientists as 2018 HHMI Hanna Gray Fellows to support diversity in science. The 2019 Hanna H. Gray Fellows Program competition is now open, with applications due on January 9, 2019.

Released: 11-Sep-2018 4:40 PM EDT
Joan A. Steitz Receives 2018 Lasker~Koshland Special Achievement Award in Medical Science
Howard Hughes Medical Institute (HHMI)

Lasker Award honors leadership in RNA biology and in scientific mentorship.

17-Aug-2018 3:00 PM EDT
3-D Cell Environment Crucial for Divvying Up Chromosomes – Find Could Help Explain Cancer Hallmark
Howard Hughes Medical Institute (HHMI)

Epithelial cells grown on a plastic dish are worse at segregating their chromosomes than epithelial cells growing in mice, a new study shows. The results may help explain why chromosomes go awry in cancer.

Released: 15-Aug-2018 9:20 AM EDT
Protein Droplets Keep Neurons at the Ready and Immune System in Balance
Howard Hughes Medical Institute (HHMI)

Discoveries by two HHMI investigators show how proteins that organize into liquid droplets inside cells make certain biological functions possible.

   
12-Jul-2018 4:45 PM EDT
Complete Fly Brain Imaged at Nanoscale Resolution
Howard Hughes Medical Institute (HHMI)

Scientists at HHMI’s Janelia Research Campus have taken detailed pictures of the entire brain of an adult female fruit fly using transmission electron microscopy.

Released: 20-Jun-2018 10:05 AM EDT
33 Schools to Support Diversity and Inclusion on Campus Through 2018 HHMI Inclusive Excellence Initiative
Howard Hughes Medical Institute (HHMI)

With grants to 33 colleges and universities, HHMI is catalyzing efforts to improve the inclusion of students from diverse backgrounds in science education.

12-Jun-2018 11:05 AM EDT
Fast-acting Cholera Vaccine Could Curb Outbreaks
Howard Hughes Medical Institute (HHMI)

A weakened version of the bacteria that causes cholera provides quick protection to rabbits. The vaccine may one day stop outbreaks of the deadly intestinal disease.

   
11-Jun-2018 1:05 PM EDT
Fish “Umbrella” Protects Stem Cells from Sun
Howard Hughes Medical Institute (HHMI)

Stem cells that make blood cells in fish flourish in the shade provided by a newly discovered cellular “umbrella” that keeps them safe from UV damage.

   
Released: 31-May-2018 12:00 PM EDT
Meet Three New Genes That May Have Influenced Human Brain Size
Howard Hughes Medical Institute (HHMI)

Three brain development genes are found only in humans and may have helped drive the rapid expansion of the brain starting roughly three million years ago.

   
18-May-2018 12:05 PM EDT
HHMI Bets Big On 19 New Investigators
Howard Hughes Medical Institute (HHMI)

HHMI invests $200 million in a small cadre of leading scientists, challenging them to push the limits of what we know about biology.

   

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