The lab of Yongchao C. Ma, PhD, at Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago discovered a fundamental biological mechanism that could lead to new treatments for neurological diseases, such as spinal muscular atrophy (SMA) and autism, as well as different cancers.
Mehul V. Raval, MD, MS, FACS, FAAP, has been named the Head of the Division of Pediatric Surgery at Ann & Robert H. Lurie Children’s Hospital of Chicago. After an extensive national search and reviewing several highly accomplished applicants, Dr. Raval’s expertise, translational research, leadership experience and dedication to Lurie Children’s set him apart. He will hold the Orvar Swenson Founders' Board Chair in Pediatric Surgery.
On March 27, 2024, Ann & Robert H. Lurie Children’s Hospital of Chicago treated its first patient with ELEVIDYS (delandistrogene moxeparvovec-rokl), the first gene therapy for Duchenne muscular dystrophy – a rare, genetic disease characterized by progressive muscle damage and weakness.
A new study found that during the pandemic pediatric emergency departments (EDs) saw more children and adolescents who needed a psychiatric admission, as well as an increase in severe conditions, such as bipolar disorder, schizophrenia and substance use disorders.
Four children who acquired HIV in utero have remained free of detectable HIV for more than one year, according to new findings that were presented today, March 6, at the Conference on Retroviruses and Opportunistic Infections (CROI) in Denver, Colo. The study is part of ongoing, multinational research led in part by scientists from Northwestern University Feinberg School of Medicine and Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago.
Scientists from Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago and Northwestern University succeeded in regenerating fully functional urinary bladder tissue in a long-term study utilizing a non-human primate model.
Clinician-scientists from Ann & Robert H. Lurie Children’s Hospital of Chicago were among a diverse, international group of experts tasked by the Society of Critical Care Medicine (SCCM) with developing and validating new data-based criteria for sepsis in children. Sepsis is a major public heath burden, claiming the lives of over 3.3 million children worldwide every year. The new pediatric sepsis criteria – called the Phoenix criteria – follow the paradigm shift in the recent adult criteria that define sepsis as severe response to infection involving organ dysfunction, as opposed to an earlier focus on systemic inflammation.
Prenatal diagnosis of congenital heart defects – the most common birth defects in the United States – is associated with improved outcomes. Despite its importance, however, overall prevalence of prenatal diagnosis is low (12-50 percent). A recent multi-center study surveyed caretakers of infants who received congenital heart surgery in the Chicago area and found that social determinants or influencers of health constitute significant barriers to prenatal diagnosis from the patients’ perspective.
An unexpectedly high percentage of children, who were born with HIV and started treatment within 48 hours of life, exhibit biomarkers by 2 years of age that may make them eligible to test for medication-free remission, according to a multinational study published in Lancet HIV.
The lab of Yongchao C. Ma, PhD, at Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago uncovered a novel mechanism that leads to motor neuron degeneration in spinal muscular atrophy (SMA).
A new study offers a novel look at the scope of the youth mental health crisis across the United States – in 2019-2020, more than 1 in 10 kids who were brought to the hospital by ambulance had a behavioral health emergency. Out of these behavioral health emergencies, 85 percent were in 12-17-year-olds. Findings were published in the journal Academic Emergency Medicine.
Pediatric Emergency Department (ED) visits for firearm injuries doubled during the pandemic compared to earlier trends, according to a multicenter study published in the journal Pediatrics.
A survey from Ann & Robert H. Lurie Children’s Hospital of Chicago found that 40 percent of parents who worked remotely during the pandemic reported higher parenting stress compared with only 27 percent of parents who worked onsite.
A study from Ann & Robert H. Lurie Children’s Hospital of Chicago demonstrated that Botulinum toxin (Botox) injected in the pylorus (sphincter where the stomach exits into the small intestine) during endoscopy improves chronic nausea and vomiting in children who have a disorder of gut-brain interaction (DGBI).
Jeffrey Raskin, MS, MD, a neurosurgeon at Ann & Robert H. Lurie Children’s Hospital of Chicago, performed the first ever computer-guided radiofrequency ablation to decrease excessive muscle tone (called hypertonia) in a child with cerebral palsy.
Researchers from Ann & Robert H. Lurie Children’s Hospital of Chicago and colleagues reported for the first time that a genetic biomarker may be able to help predict the severity of food allergy reactions.
The Texas A&M University schools of nursing and public health have jointly been awarded a five-year, $7.4 million grant from the U.S. Department of Health and Human Services (HHS) to promote positive adolescent health behavior in one of the country’s largest metropolitan areas. The project is a collaboration with Ann & Robert H. Lurie Children’s Hospital of Chicago.
Discovery from the lab of Youyang Zhao, PhD, from Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago offers promising treatment approaches for acute respiratory distress syndrome (ARDS) in the elderly that can be caused by severe COVID-19, pneumonia, flu or sepsis.
A study from Ann & Robert H. Lurie Children’s Hospital of Chicago has shown that prenatal diagnosis, or diagnosis before a baby is born, is associated with earlier surgery for babies with congenital heart defects, the most common birth defects affecting nearly 1% of all live births. The association was demonstrated for critical defects (when heart surgery is required before the infant leaves the hospital) and certain types of noncritical defects, which constitute about 75% of all congenital heart defects.
Newborn screening for cystic fibrosis (CF) was fully implemented in all 50 states in the U.S. by 2010, but delays in timeliness of evaluation for infants with positive newborn screen tests persist. Through evaluation of national patient registry data, Dr. Martiniano and her team determined that later initiation of CF care is associated with poorer long-term nutritional outcomes.
Research from Ann & Robert H. Lurie Children’s Hospital of Chicago found that direct injection of neonatal mesenchymal stem cells, derived from heart tissue discarded during surgery, reduces intestinal inflammation and promotes wound healing in a mouse model of Crohn’s disease-like ileitis, an illness marked by chronic intestinal inflammation and progressive tissue damage.
Ann & Robert H. Lurie Children’s Hospital of Chicago is leading an awareness campaign that aims to reduce missed or delayed diagnosis of cystic fibrosis after newborn screening, especially in non-White infants. In its first phase, the campaign targets primary care providers and public health officials, so that treatment can start earlier, which is linked to better outcomes for people with cystic fibrosis. The general public phase is expected to follow within the year.
Errors in installation of child car seats are common, even with seats that have a five-star rating for ease of use, according to a study published in the journal Traffic Injury Prevention. The study found that although the rating system was a suitable indicator of ease of use, with fewer errors detected when parents installed seats that had higher ratings, more efforts are needed to ensure optimal safety for young passengers.
A research team led by Kelly Michelson, MD, MPH, FCCM, FAAP, HEC-C, and Stacy Tessler Lindau, MD, MA, has been approved for a $6,155,096 million research funding award by the Patient-Centered Outcomes Research Institute (PCORI) to study, “The Missing Pieces Trial: A Multi-Site Pragmatic Comparative Effectiveness Trial of Interventions to Support Parents After Their Child's Unexpected or Traumatic Death.”
As a result of the COVID-19 pandemic, respiratory syncytial virus (RSV) surges in young children occurred outside the usual November to March season, when immune-based prophylactic is available to protect children at high risk for severe illness.
The percentage of infants from the neonatal intensive care unit (NICU) experiencing hypothermia upon operating room (OR) arrival and at any point during the operation decreased from 48.7% to 6.4% and 67.5% to 37.4%, respectively, after implementation of a multidisciplinary quality improvement project at Ann & Robert H. Lurie Children’s Hospital of Chicago. The project and its success were featured in the journal Pediatric Quality and Safety.
Research from Ann & Robert H. Lurie Children’s Hospital of Chicago promises to spare many premature infants from undergoing invasive eye exams to detect retinopathy of prematurity (ROP), the most common cause of preventable lifelong blindness in children in the U.S.
Fathers can make a huge difference in whether an infant is breastfed and placed to sleep safely, according to a recent survey of new fathers via the Pregnancy Risk Assessment Monitoring System (PRAMS) for Dads. This new tool is modeled on the annual surveillance system that the Centers for Disease Control and Prevention (CDC) and public health departments have used for more than 35 years to survey new mothers. By utilizing PRAMS for Dads, this article is the first to describe father-reported rates of infant breastfeeding and sleep practices in a state-representative sample. Findings are published in the journal Pediatrics.
More than three in five children (63 percent) enrolled in Medicaid do not receive mental health services within six months after a firearm injury, according to a new study published in the journal Pediatrics.
Survival rate beyond 10 years in children with drug-resistant epilepsy (DRE) was highest after cranial epilepsy surgery and lowest when treated only with antiseizure medications, according to a study published in The Lancet Child and Adolescent Health. This large, retrospective study was the first to compare long-term survival in children with DRE among cohorts treated with medications only, vagus nerve stimulation plus medications, and cranial epilepsy surgery plus medications. Results show that risk of early death was reduced by over 80 percent after surgery and by 40 percent after vagus nerve stimulation, compared to medication-only treatment.
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