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Duke Health is among a leading group of health systems and payers from across the U.S. to sign a pledge advancing ethical and responsible use of Artificial Intelligence technology in health care.

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Duke Health is embarking on a five-year, innovative partnership with Microsoft aimed at responsibly and ethically harnessing the potential of generative artificial intelligence (AI) and cloud technology to redefine the health care landscape.

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Today, the National Institutes of Health launched and is opening enrollment for phase 2 clinical trials that will evaluate at least four potential treatments for long COVID, with additional clinical trials to test at least seven more treatments expected in the coming months. Treatments will include drugs, biologics, medical devices and other therapies.

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A study led by Duke Health physicians, appearing online June 8 in the New England Journal of Medicine, found that DCD hearts were equivalent to hearts procured through the current standard of care.

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A drug combination that shows little overall survival benefit in white men with advanced prostate cancer has a far greater effect in Black men with the disease, according to interim results from a study led by the Duke Cancer Institute.

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A family history of cancer and genetic variants that might be inherited appear to be important risk factors for Black men diagnosed with early-onset prostate cancer, a study involving Duke Health researchers has found.

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A team of researchers mapping a molecular atlas for ductal carcinoma in situ (DCIS) has made a major advance toward distinguishing whether the early pre-cancers in the breast will develop into invasive cancers or remain stable.

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An immune response that likely evolved to help fight infections appears to be the mechanism that drives human immunodeficiency virus (HIV) into a latent state, lurking in cells only to erupt anew, researchers at Duke Health report.

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In the battle of the sexes, women beat men in their ability to recover from kidney injury, but the reasons are not well understood. A study led by Duke Health researchers provides some insights: Females, it turns out, have an advantage at the molecular level that protects them from a form of cell death that occurs in injured kidneys. This protection could be exploited as a potential therapeutic.

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A study comparing two approaches for diagnosing heart disease found that a risk analysis strategy is superior to the usual approach of immediately performing functional tests or catheterization for low- to intermediate-risk patients with new-onset chest pain.

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For more than four decades, doctors have been split on whether giving steroids during a pediatric open-heart surgery could be helpful for post-operative recovery. A new study is providing a bit more clarity, suggesting there are some benefits for certain kinds of patients.

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In a head-to-head comparison of two so-called ‘water pills’ that keep fluid from building up in patients with heart failure, the therapies proved nearly identical in reducing deaths, according to a large study led by Duke Health researchers.

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A new study led by Duke Health found that advanced practice clinicians received more payments from drug companies, while physicians accepted more funds from medical device companies. The same proportion of each group accepted payments, but the physicians received a much greater sum.

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A study led by the Duke Clinical Research Institute (DCRI) in partnership with Vanderbilt University found no symptomatic or clinical benefit to taking the antidepressant fluvoxamine 50 mg twice daily for 10 days for the treatment of mild-to-moderate COVID-19 symptoms.

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Duke University and the National University of Singapore (NUS) today reaffirmed their commitment to Duke-NUS Medical School—Singapore’s flagship graduate-entry, research-focused medical school—by renewing their partnership agreement.

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Programs that distributed more than 2 million at-home COVID-19 tests to counties in North Carolina, Tennessee, and California with large underrepresented racial and ethnic populations were successful in getting test kits into the hands of community members and changing people’s behaviors in support of public health.

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The Duke Clinical Research Institute (DCRI) will help establish a new nationwide center that will accelerate and expand the dissemination of the latest research on addiction and overdose to help communities devastated by the opioid crisis.

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A new model to predict the life expectancy of older people relies less on their specific disease diagnoses and more on factors such as the ability to grocery shop, the amount of certain small cholesterol particles circulating in their blood, and whether they never or only occasionally smoked.

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COVID exacted a huge toll on the wellbeing of health care workers. Already struggling with high levels of emotional exhaustion going into the pandemic, the problem grew even worse after two years of managing the crisis. Nurses have been especially hard hit.

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To block infection from HIV, a successful vaccine will require a combination of ingredients, including at least three antibody targets and a substance that boosts immune responses. In a step toward achieving that goal, one potential vaccine component has led to strong protection in primates by eliciting an antibody that binds to part of the virus’s outer envelope, reports a team led by researchers at the Duke Human Vaccine Institute (DHVI).

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The Duke Clinical Research Institute (DCRI) has been named the Clinical Trials Data Coordinating Center for large-scale national research studies aimed at understanding and improving the treatment of long COVID.

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A genetic risk for heart disease is far less predictive of problems than actual lifestyle risk factors such as high blood pressure, high cholesterol and diabetes -- even among younger adults.

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A study led by the Duke Clinical Research Institute (DCRI) in partnership with Vanderbilt University found no symptomatic or clinical benefit to taking fluticasone furoate for the treatment of mild-to-moderate COVID-19 symptoms.

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A monoclonal antibody treatment taken by patients hospitalized with COVID-19 did not improve recovery time but did reduce deaths, according to a study published July 8 in The Lancet Respiratory Medicine.

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Fish oil triglycerides appear to be effective at reducing instances of inflammation in the brain and preventing post-surgical delirium in mice and tissue engineered human models, according to Duke Health and Duke Biomedical Engineering researchers.

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Researchers have unmasked a component of the cell death process that could play a vital role in a better infection-fighting strategy.

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Duke Children’s Hospital & Health Center continues to rank as the No. 1 children’s hospital in North Carolina by U.S. News & World Report, with nine pediatric specialties ranked among the best in the nation.

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A study led by the Duke Clinical Research Institute (DCRI) in partnership with Vanderbilt University found no differences in relief of mild-to-moderate COVID-19 symptoms between participants taking ivermectin and participants taking a placebo.

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An investigational drug taken while undergoing chemotherapy demonstrated superior overall survival compared to chemotherapy alone in adult patients with a common, highly aggressive subtype of acute myeloid leukemia (AML).

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A review of studies about the effect of food insecurity on digestive diseases found a dearth of information, even as diet can often be both a direct cause of and a solution for many gastrointestinal conditions.

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COVID-19 health care workers experienced high rates of potential moral injury that are comparable to rates among military veterans, according to a collaborative study between Duke University, Vanderbilt University, and the Department of Veterans Affairs (VA).

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Medicare patients whose implantable heart devices became infected were less likely to die from the complication if they had the hardware removed compared to patients who only received antibiotics, according to the largest study on the topic, led by the Duke Clinical Research Institute.

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A new type of anti-clotting drug caused fewer bleeding incidents among patients with atrial fibrillation than the commonly prescribed apixaban, according to results from a head-to-head comparison of the two.

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Heart failure patients taking the investigational drug omecamtiv mecarbil, which has been previously shown to improve long-term outcomes, see little impact on their ability to exercise compared to a placebo, according to a study supported by the Duke Clinical Research Institute.

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Searching for ways to extend the survival benefit of targeted therapies, a team led by researchers at the Duke Cancer Institute identified a potential new tactic to disrupt the repair mechanism that cancer cells use after treatment, blunting their ability to regenerate. The approach could present a new treatment strategy.

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Using mRNA technology like that in the COVID-19 vaccines, researchers have demonstrated a successful way to deliver a potential HIV vaccine, researchers at Duke Human Vaccine Institute report.

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School districts that required masking saw lower rates of COVID-19 transmission within schools last fall compared to those with optional masking policies, according to a study by the ABC Science Collaborative.

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Health care workers who have children under age 5 are twice as likely as other parents to plan to vaccinate their children against COVID-19, according to a new poll conducted by the HERO Registry, which is coordinated by the Duke Clinical Research Institute.

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A study led by the Duke Clinical Research Institute (DCRI) in partnership with Vanderbilt University has expanded its testing platform to evaluate ivermectin at a higher dose for a longer period of time.

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MRI scans of children aged 9–10 years with ADHD showed few differences in structural brain measurements compared to their unaffected peers, according to a study led by a Duke University School of Medicine researcher.

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Cognitive changes following non-neurologic and non-cardiac surgery were not associated with changes in Alzheimer’s disease-related biomarkers in older patients, according to a study led by a team at Duke University School of Medicine.

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Hospital rooms where COVID patients were treated had little to no active virus contaminations on surfaces, according to a study at Duke University Hospital that adds to the body of research on how the pandemic respiratory virus is spread.

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Some prostate cancers might also include a small number of aggressive cells hiding among the indolent ones like wolves in a herd of sheep. Researchers at Duke Health have identified a molecular signature that can spot these lurking threats.

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the NIH Collaboratory is donning a new name—NIH Pragmatic Trials Collaboratory—that will carry the highly successful program into the future with a continued commitment to transforming clinical research. The program was formerly known as the NIH Health Care Systems Research Collaboratory. Its new moniker reflects the program’s core mission of strengthening the national capacity to implement cost-effective, large-scale research studies conducted within healthcare delivery systems, also known as pragmatic trials.