Latest News from: St. Jude Children's Research Hospital

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Newswise: St. Jude taps health care start-up veteran as first Senior Vice President of Tech Commercialization
Released: 20-Feb-2024 11:45 AM EST
St. Jude taps health care start-up veteran as first Senior Vice President of Tech Commercialization
St. Jude Children's Research Hospital

Jordan will work with researchers to bring a greater number of new technologies, innovations and scientific breakthroughs to the clinic, enabling breakthroughs from St. Jude laboratories to benefit more patients.

Newswise: Novel bispecific design improves CAR T–cell immunotherapy for childhood leukemia
Released: 12-Feb-2024 11:55 AM EST
Novel bispecific design improves CAR T–cell immunotherapy for childhood leukemia
St. Jude Children's Research Hospital

Findings from St. Jude Children’s Research Hospital showed a novel dual targeting approach, where a single molecule can recognize two potential cancer-related proteins, is more effective than the single targeting approach, preventing immune escape.

Newswise: Sara Federico, MD, named director of the Solid Tumor Division at St. Jude Children’s Research Hospital
Released: 7-Feb-2024 2:05 PM EST
Sara Federico, MD, named director of the Solid Tumor Division at St. Jude Children’s Research Hospital
St. Jude Children's Research Hospital

Established clinician researcher will focus on novel treatments and clinical trials for difficult-to-treat childhood cancers.

Newswise: Inaugural class of Damon Runyon–St. Jude Pediatric Cancer Research Fellows announced
Released: 1-Feb-2024 9:00 AM EST
Inaugural class of Damon Runyon–St. Jude Pediatric Cancer Research Fellows announced
St. Jude Children's Research Hospital

The initiative aims to provide support for early-career scientists to study pediatric cancer, addressing a funding gap that drives top talent to seek more prevalent opportunities in adult cancer research or the pharmaceutical sector.

Newswise: St. Jude Children’s Research Hospital adds $13 million project to Research Collaboratives Program
18-Jan-2024 11:00 AM EST
St. Jude Children’s Research Hospital adds $13 million project to Research Collaboratives Program
St. Jude Children's Research Hospital

As outlined in the 2022-2027 Strategic Plan, the St. Jude Research Collaboratives program is part of an overall effort by the institution to fund collaborative research addressing complex scientific problems with transformative potential for the diseases treated at St. Jude.

Newswise: St. Jude Home Care, LLC is first U.S. pediatric home health agency to earn new category of industry certification
Released: 16-Jan-2024 1:45 PM EST
St. Jude Home Care, LLC is first U.S. pediatric home health agency to earn new category of industry certification
St. Jude Children's Research Hospital

The home health agency for St. Jude Children's Research Hospital outpatients earned dual certifications in both pediatrics and home health, the nation’s first such agency to achieve that distinction.

Newswise: Molecular ‘super-glue’ shows promise of cancer drug discovery platform
Released: 16-Jan-2024 12:05 PM EST
Molecular ‘super-glue’ shows promise of cancer drug discovery platform
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital collaborated to identify and improve a chemical compound that acts as a molecular “super-glue” with broad activity across cancers.

Newswise: HOXA9 tracking reveals RBM5 dual function and therapeutic potential for acute myeloid leukemia
Released: 12-Jan-2024 2:05 PM EST
HOXA9 tracking reveals RBM5 dual function and therapeutic potential for acute myeloid leukemia
St. Jude Children's Research Hospital

Using CRISPR/Cas9, scientists at St. Jude Children’s Research Hospital identified RBM5 as a vital component of leukemia cell fitness, making it a promising target for drug development.

Newswise: Two common biomarkers predict heart risk in asymptomatic childhood cancer survivors
Released: 12-Jan-2024 1:05 PM EST
Two common biomarkers predict heart risk in asymptomatic childhood cancer survivors
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital found that two common biomarkers could predict cardiomyopathy that is otherwise undetected by conventional screenings in childhood cancer survivors.

Newswise: Updated genomic landscape for pediatric acute myeloid leukemia enables new treatment possibilities
Released: 11-Jan-2024 11:05 AM EST
Updated genomic landscape for pediatric acute myeloid leukemia enables new treatment possibilities
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital refined and enhanced the classification system for a type of pediatric leukemia using genomic and transcriptomic analysis.

Newswise: Acute pediatric critical illness definition enables global research
Released: 8-Jan-2024 12:05 PM EST
Acute pediatric critical illness definition enables global research
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital collaborated with a global group to create a more inclusive and standardized criterion for acute pediatric critical illness, with implications for improving care.

Newswise: A new approach can address antibiotic resistance to Mycobacterium abscessus
Released: 5-Jan-2024 11:05 AM EST
A new approach can address antibiotic resistance to Mycobacterium abscessus
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital created analogs of the antibiotic spectinomycin that are significantly more effective against these highly resistant bacteria.

Newswise: Elusive cytonemes guide neural development, provide signaling ‘express route’
Released: 2-Jan-2024 11:05 AM EST
Elusive cytonemes guide neural development, provide signaling ‘express route’
St. Jude Children's Research Hospital

Discover the first images of cytonemes during mammalian neural development, serving as express routes to establish morphogen gradients and tissue patterning.

Newswise: GPCR structure: Research reveals molecular origins of function for a key drug target
Released: 21-Dec-2023 3:05 PM EST
GPCR structure: Research reveals molecular origins of function for a key drug target
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital reveal how G protein-coupled receptors, major therapeutic drug targets, decode critical properties of their ligands.

Newswise: Structures of Parkinson’s disease-linked proteins offer a framework for understanding how they work together
Released: 21-Dec-2023 3:05 PM EST
Structures of Parkinson’s disease-linked proteins offer a framework for understanding how they work together
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital used cryo-electron microscopy to characterize the interaction of two proteins implicated in Parkinson’s disease.

Newswise: Unraveling predisposition in bilateral Wilms tumor
Released: 18-Dec-2023 11:05 AM EST
Unraveling predisposition in bilateral Wilms tumor
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital identified genetic and epigenetic mechanisms driving predisposition to this childhood kidney cancer, impacting care and treatment.

Newswise: Prediabetes treatment may reduce heart and kidney risks in childhood cancer survivors
13-Dec-2023 12:05 PM EST
Prediabetes treatment may reduce heart and kidney risks in childhood cancer survivors
St. Jude Children's Research Hospital

Childhood cancer survivors have a higher prevalence of prediabetes and diabetes, which increases their risk of serious disease but also offers opportunities for prevention.

Released: 6-Dec-2023 10:05 AM EST
St. Jude research featured at the American Society of Hematology Annual Meeting
St. Jude Children's Research Hospital

St. Jude researchers will participate in multiple oral and poster presentations and education sessions as well as moderate panels during the ASH conference.

Newswise: Modular chimeric cytokine receptors improve CAR T–cell therapy for solid tumors
Released: 30-Nov-2023 11:05 AM EST
Modular chimeric cytokine receptors improve CAR T–cell therapy for solid tumors
St. Jude Children's Research Hospital

Adding a modular chimeric cytokine receptor to CAR T cells increased their efficacy. Learn how this modular system could improve brain and solid tumor therapy.

   
Newswise: St. Jude revealed functional targets of oncogenic HOXA9 in high-risk pediatric leukemia
Released: 28-Nov-2023 11:05 AM EST
St. Jude revealed functional targets of oncogenic HOXA9 in high-risk pediatric leukemia
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital identified target genes bound and regulated by HOXA9, a protein overexpressed in high-risk leukemia, extending understanding and opening new possibilities for treatment.

Newswise: Promising target for CAR T cells helps cancer trick the immune system
Released: 21-Nov-2023 11:05 AM EST
Promising target for CAR T cells helps cancer trick the immune system
St. Jude Children's Research Hospital

Immunotherapy using modified chimeric antigen receptor (CAR) T cells has greatly improved survival rates for relapsed and recurrent pediatric leukemia and lymphomas, but not brain and solid tumors.

Newswise: Robust chromatin map explains heterogeneity of pediatric acute lymphoblastic leukemia
Released: 20-Nov-2023 10:05 AM EST
Robust chromatin map explains heterogeneity of pediatric acute lymphoblastic leukemia
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital mapped the difference in chromatin accessibility and regulation in different pediatric acute lymphoblastic leukemia subtypes.

Newswise: Fusion oncoprotein forces cell fates toward rhabdomyosarcoma
Released: 15-Nov-2023 12:05 PM EST
Fusion oncoprotein forces cell fates toward rhabdomyosarcoma
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital showed that a fusion oncoprotein can drive molecularly indistinguishable rhabdomyosarcomas arising from both muscle and blood vessel cells.

Newswise: St. Jude scientists identify T-cell differentiation nodes to improve cancer-killing
Released: 15-Nov-2023 11:05 AM EST
St. Jude scientists identify T-cell differentiation nodes to improve cancer-killing
St. Jude Children's Research Hospital

St. Jude scientists mapped the gene regulatory networks responsible for progressive differentiation states of tumor-infiltrating T cells, using a technology known as single-cell CRISPR screening to knock out or genetically perturb multiple genes potentially involved.

Newswise: Giles Robinson, M.D., named director of the Neuro-Oncology Division at St. Jude Children’s Research Hospital
Released: 7-Nov-2023 10:00 AM EST
Giles Robinson, M.D., named director of the Neuro-Oncology Division at St. Jude Children’s Research Hospital
St. Jude Children's Research Hospital

He has also become co-leader of the Neurobiology and Brain Tumor Program within the St. Jude Comprehensive Cancer Center. These combined units comprise one of the largest clinical brain tumor programs in North America.

Newswise: Scientists reveal structures of neurotransmitter transporter
30-Oct-2023 1:05 PM EDT
Scientists reveal structures of neurotransmitter transporter
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital determined structures of a transporter protein involved in the movement of neurochemicals such as serotonin and dopamine, unearthing multiple mechanisms that can guide drug development.

   
Newswise: St. Jude Children’s Research Hospital, ALSAC Announce New Board Leaders
Released: 16-Oct-2023 10:00 AM EDT
St. Jude Children’s Research Hospital, ALSAC Announce New Board Leaders
St. Jude Children's Research Hospital

St. Jude Children’s Research Hospital and ALSAC, its fundraising and awareness organization, announced new leaders of the St. Jude Board of Governors and ALSAC Board of Directors today. The announcement comes at a time when St. Jude is advancing the largest strategic investment in its 61-year history.

Newswise: 3D genome architecture influences SCID-X1 gene therapy success
Released: 6-Oct-2023 2:05 PM EDT
3D genome architecture influences SCID-X1 gene therapy success
St. Jude Children's Research Hospital

In 2019, St. Jude lentiviral gene therapy restored the immune system in multiple infants of X-linked severe combined immunodeficiency disorder (SCID-X1) or “bubble boy disease” at the DNA level. These children can now produce functional immune systems.

   
Newswise: Host genetics helps explain childhood cancer survivors’ mortality risk from second cancers
2-Oct-2023 4:00 PM EDT
Host genetics helps explain childhood cancer survivors’ mortality risk from second cancers
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital unraveled the genetics increasing the chance of survivors developing a second cancer later in life and its severity and prognosis to guide future cancer prevention.

Newswise: Predicting condensate formation by cancer-associated fusion oncoproteins
26-Sep-2023 1:05 PM EDT
Predicting condensate formation by cancer-associated fusion oncoproteins
St. Jude Children's Research Hospital

St. Jude researchers shed light on a key player in cancer development by exploring the ability of fusion oncoproteins to form condensates in cells.

Newswise: St. Jude Children’s Research Hospital Unveils The Domino’s Village
27-Sep-2023 11:25 AM EDT
St. Jude Children’s Research Hospital Unveils The Domino’s Village
St. Jude Children's Research Hospital

The new patient family housing building was made possible by a multi-million dollar donation from the pizza giant.

Newswise: St. Jude refines definition and hones treatment of hyperdiploid leukemia
19-Sep-2023 3:20 PM EDT
St. Jude refines definition and hones treatment of hyperdiploid leukemia
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital may be able to better predict outcomes and treat patients with the most common childhood cancer by more clearly defining hyperdiploidy.

Newswise: Specialized T cells in the brain slow progression of Alzheimer’s disease
Released: 7-Sep-2023 12:05 PM EDT
Specialized T cells in the brain slow progression of Alzheimer’s disease
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital found that a subset of CD8+ T cells in the brain lessens the activation of microglia and limits disease pathology in a model of Alzheimer’s disease.

Newswise: St. Jude shows cancer resistance protein can have its cake and eat it too
Released: 21-Aug-2023 11:05 AM EDT
St. Jude shows cancer resistance protein can have its cake and eat it too
St. Jude Children's Research Hospital

Scientists at St. Jude Research Hospital unravel the mechanisms behind a key culprit in chemotherapy resistance.

Newswise: Immune cells present long before infection predict flu symptoms
Released: 17-Aug-2023 12:35 PM EDT
Immune cells present long before infection predict flu symptoms
St. Jude Children's Research Hospital

St. Jude Children’s Research Hospital scientists found that immune cells present in individuals long before influenza infection predict whether the illness is symptomatic.

Newswise: St. Jude names Sarah Currie chief nursing executive and senior vice president
Released: 8-Aug-2023 7:00 AM EDT
St. Jude names Sarah Currie chief nursing executive and senior vice president
St. Jude Children's Research Hospital

Award-winning NICU expert spent 21 years at Children’s Wisconsin, including four years as executive director of perinatal and neonatal services.

Newswise: Mutation accessibility fuels influenza evolution
28-Jul-2023 12:30 PM EDT
Mutation accessibility fuels influenza evolution
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital showed that fixed mutations within a viral population most likely stem from how easy it is to acquire that mutation (i.e., mutation accessibility) rather than just its benefit.

Newswise: Jinghui Zhang, PhD, elected Fellow of the International Society for Computational Biology
Released: 27-Jul-2023 11:00 AM EDT
Jinghui Zhang, PhD, elected Fellow of the International Society for Computational Biology
St. Jude Children's Research Hospital

Former Chair of Computational Biology honored with induction into Class of 2023 Fellows.

Newswise: Pediatric hepatoblastoma model hints at DNA damage repair pathway for novel therapeutics
Released: 10-Jul-2023 8:15 AM EDT
Pediatric hepatoblastoma model hints at DNA damage repair pathway for novel therapeutics
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital used genomics to inform the creation of genetic and new cell-line models for hepatoblastoma, which pointed toward the DNA damage repair pathway as a promising therapeutic route.

Newswise: Pediatric Early Warning Systems save lives in Latin American hospitals
Released: 10-Jul-2023 8:15 AM EDT
Pediatric Early Warning Systems save lives in Latin American hospitals
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital and colleagues in Latin America found that early identification of clinical deterioration saves lives, especially in hospitals with the greatest need.

Newswise: Immune and tumor cell “tug-of-war” controls anti-cancer activity
Released: 5-Jul-2023 11:55 AM EDT
Immune and tumor cell “tug-of-war” controls anti-cancer activity
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital found that altering amounts of the nutrient glutamine in the tumor microenvironment could enhance or impair the immune system’s anti-cancer response.

Newswise: Base editing shows potential superiority for curing sickle cell disease
Released: 3-Jul-2023 11:00 AM EDT
Base editing shows potential superiority for curing sickle cell disease
St. Jude Children's Research Hospital

Gene therapy that alters hemoglobin genes may be an answer to curing sickle cell disease and beta thalassemia. Scientists at St. Jude Children’s Research Hospital and the Broad Institute of MIT and Harvard found base editing increased fetal hemoglobin production in a new treatment.

Newswise: St. Jude finds NLRP12 as a new drug target for infection, inflammation and hemolytic diseases
Released: 1-Jun-2023 3:40 PM EDT
St. Jude finds NLRP12 as a new drug target for infection, inflammation and hemolytic diseases
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital found key “on” switch, NLRP12, for innate immune cell death in diseases that cause red blood cells to rupture, which can lead to inflammation and multi-organ failure.

Newswise: Genetic change increased bird flu severity during U.S. spread
Released: 30-May-2023 1:15 PM EDT
Genetic change increased bird flu severity during U.S. spread
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital have discovered H5N1 avian influenza viruses gained the ability to cause severe disease and target the brain in mammals as they spread across North America.

   
Newswise: Epigenetic landscape modulates pioneer transcription factor binding
Released: 24-May-2023 3:05 PM EDT
Epigenetic landscape modulates pioneer transcription factor binding
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital studied how the epigenetic landscape influences the binding of pioneer transcription factors, affecting access to DNA.

Newswise: SWI/SNF complexes “bookmark” cell identity during division
Released: 24-May-2023 11:15 AM EDT
SWI/SNF complexes “bookmark” cell identity during division
St. Jude Children's Research Hospital

Read about how Scientists at St. Jude determined how the SWI/SNF chromatin remodeling complex helps cancer cells remember how to be cancerous after division.

Newswise: Capturing transporter structure paves the way for drug development
Released: 23-May-2023 2:05 PM EDT
Capturing transporter structure paves the way for drug development
St. Jude Children's Research Hospital

Scientists report six structures of the Spns2 transporter, which is linked to cancer and other diseases, including while it is bound to a small molecule inhibitor, thus aiding future therapeutic design.

Newswise: St. Jude scientist M. Madan Babu elected to the Royal Society of London
Released: 10-May-2023 10:00 AM EDT
St. Jude scientist M. Madan Babu elected to the Royal Society of London
St. Jude Children's Research Hospital

The Director of the Center of Excellence for Data-Driven Discovery at St. Jude Children’s Research Hospital was named a Fellow of the leading, 360-year-old British scientific organization. The Royal Society is the oldest scientific academy in continuous existence.

Newswise: St. Jude tool gets more out of multi-omics data
Released: 4-May-2023 12:05 PM EDT
St. Jude tool gets more out of multi-omics data
St. Jude Children's Research Hospital

An upgraded computational tool from St. Jude Children’s Research Hospital can find potentially druggable hidden drivers of cancer and other biological processes using multi-omics data.

   


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