Scientists at St. Jude Children’s Research Hospital showed that fixed mutations within a viral population most likely stem from how easy it is to acquire that mutation (i.e., mutation accessibility) rather than just its benefit.
Former Chair of Computational Biology honored with induction into Class of 2023 Fellows.
Scientists at St. Jude Children’s Research Hospital used genomics to inform the creation of genetic and new cell-line models for hepatoblastoma, which pointed toward the DNA damage repair pathway as a promising therapeutic route.
Scientists at St. Jude Children’s Research Hospital and colleagues in Latin America found that early identification of clinical deterioration saves lives, especially in hospitals with the greatest need.
Scientists at St. Jude Children’s Research Hospital found that altering amounts of the nutrient glutamine in the tumor microenvironment could enhance or impair the immune system’s anti-cancer response.
Gene therapy that alters hemoglobin genes may be an answer to curing sickle cell disease and beta thalassemia. Scientists at St. Jude Children’s Research Hospital and the Broad Institute of MIT and Harvard found base editing increased fetal hemoglobin production in a new treatment.
Scientists at St. Jude Children’s Research Hospital found key “on” switch, NLRP12, for innate immune cell death in diseases that cause red blood cells to rupture, which can lead to inflammation and multi-organ failure.
Scientists at St. Jude Children’s Research Hospital have discovered H5N1 avian influenza viruses gained the ability to cause severe disease and target the brain in mammals as they spread across North America.
Scientists at St. Jude Children’s Research Hospital studied how the epigenetic landscape influences the binding of pioneer transcription factors, affecting access to DNA.
Read about how Scientists at St. Jude determined how the SWI/SNF chromatin remodeling complex helps cancer cells remember how to be cancerous after division.
Scientists report six structures of the Spns2 transporter, which is linked to cancer and other diseases, including while it is bound to a small molecule inhibitor, thus aiding future therapeutic design.
The Director of the Center of Excellence for Data-Driven Discovery at St. Jude Children’s Research Hospital was named a Fellow of the leading, 360-year-old British scientific organization. The Royal Society is the oldest scientific academy in continuous existence.
An upgraded computational tool from St. Jude Children’s Research Hospital can find potentially druggable hidden drivers of cancer and other biological processes using multi-omics data.
Scientists from St. Jude Children’s Research Hospital investigated neighborhood-level economic hardship and its effect on cognitive outcomes in children treated with radiation for brain tumors. The results imply that policies and resources providing support at a neighborhood level may help protect high-risk pediatric brain tumor patients from cognitive decline.
Investigators from St. Jude Children’s Research Hospital found that proton therapy had efficacy similar to conventional photon therapy with fewer negative neurocognitive outcomes. The clinical trial may set the new "gold standard" for pediatric craniopharyngioma treatment.
Scientists at St. Jude Children’s Research Hospital and the Broad Institute of MIT and Harvard showed how prime editing can correct mutations that cause sickle cell disease in a potentially curative approach.
The American Association of Cancer Research (AACR) will honor two investigators from St. Jude Children’s Research Hospital for their research contributions. Melissa Hudson, M.D., director of the Cancer Survivorship Division and Jun J. Yang, Ph.D., vice-chair of Pharmacy and Pharmaceutical Sciences
St. Jude Children’s Research Hospital scientists developed a combination therapy for a leukemia subtype harboring rearrangements in the KMT2A gene. The approach overcomes the cancer’s drug resistance, without adding toxicity. The study appears in Proceedings of the National Academy of Science.
St. Jude Children’s Research Hospital researchers found childhood cancer survivors have higher mortality than the public, but survivors with a healthy lifestyle and fewer heart disease risk factors had lower risk.
Scientists at St. Jude Children’s Research Hospital comprehensively characterized oncogenic fusions in pediatric cancer, providing proof-of-principle for genetic engineering-based therapies.
Scientists at St. Jude Children’s Research Hospital have found that human ribosomes decode mRNA slower than bacteria, with implications for drug development.
National leader in the field of childhood cancer survivorship will spearhead research and advancements.
The seasonal flu vaccine is less effective in some years than others. New St. Jude research showed one reason behind this lack of efficacy is the inclusion of flu strains with an unstable viral protein.
The cystic fibrosis transmembrane conductance regulator has been studied for years but the combined efforts of St. Jude Children’s Research Hospital and Rockefeller University have yielded new insights.
Scientists at St. Jude Children’s Research Hospital showed an effective method to avoid activating a major cellular detoxification receptor to overcome drug resistance and toxicity.
Kevin Krull, PhD, a neuropsychologist at St. Jude Children’s Research Hospital, has been appointed chair of the institution’s newly renamed Department of Psychology and Biobehavioral Sciences after a national search.
Internationally renowned expert will focus on growing St. Jude into a global leader in infectious diseases research.
This free online resource of information and education for families facing childhood and adolescent cancer has a truly global reach.
Scientists at St. Jude Children’s Research Hospital solved the 3D structure of a protein in cilia, an organelle important to many diseases at nearly ten times the resolution of previous efforts.
St. Jude Children’s Research Hospital researchers find increased risk of mortality in childhood cancer survivors is associated independently with local poverty, chronic conditions and frailty.
Scientists at St. Jude Children’s Research Hospital used deep sequencing data from childhood cancer survivors and found the mutational fingerprint of a toxic chemotherapy associated with a marker of accelerated aging.
St. Jude scientists added a small physical structure called an anchor domain to the CAR molecule. The anchor domain connects the CAR to the internal infrastructure of the immune cell. It augments and helps organize the immune synapse
Immunologist recognized for her achievements in the field of innate immunity, developing new concepts in inflammasome biology and inflammatory cell death, PANoptosis.
Julie R. Park, M.D. to succeed longtime chair Ching-Hon Pui, M.D.
Scientists at St. Jude Children’s Research Hospital used the auxin-inducible degron 2 system on CTCF, bringing the novel approach to bear on a fundamental protein.
Scientists at St. Jude Children’s Research Hospital captured the 3D structure of SPOP, revealing how mutations in previously unappreciated regions fuel cancer.
Scientists from St. Jude Children’s Research Hospital performed the largest study yet examining drug sensitivity in childhood acute lymphoblastic leukemia across genomic subtypes and its association with treatment response.
By simulating molecular dynamics, scientists from St. Jude Children’s Research Hospital revealed how the selectivity or promiscuity of GPCR coupling relies on the location and duration of intermolecular interactions.
Scientists at St. Jude Children’s Research Hospital created a model to study the role of RNA splicing defects in Alzheimer’s disease, revealing degeneration and toxicity caused by neuron hyperexcitability.
Large-scale collaboration will leverage each institution’s expertise and infrastructure to advance understanding of the biological basis of pediatric cancers, identify new vulnerabilities of these diseases and accelerate cures globally.
St. Jude Children’s Research Hospital scientists found the cellular response to low oxygen also increases fetal hemoglobin expression in adults, which could lead to novel treatments for some common genetic anemias.
Scientists from St. Jude Children's Research Hospital identified the mechanism by which the disorder enhances the ability to discriminate between sounds as interneuron hyperexcitability in the auditory cortex.
St. Jude scientists have created a tool that can find safe places to put corrected genes into the genome, called safe harbor sites, using genomic and epigenetic information from specific tissue, such as blood cells.
Scientists from St. Jude Children’s Research Hospital found that group 3 and 4 medulloblastoma arise from the rhombic lip, knowledge that may help improve research models and therapeutic development.
The St. Jude Comprehensive Cancer Center award extends its current $35 million, five-year Cancer Center Support Grant (CCSG) for an additional two years.
Large populations studies have previously demonstrated that Hodgkin lymphoma occurs in families, pointing to a likely genetic predisposition that makes these families more likely to develop this cancer.
Scientists at St. Jude Children’s Research Hospital discovered how some cancer cells survive treatment and cause cancer to recur, along with a potential way to stop the process.
Scientists at St. Jude sequenced more samples of the most common childhood cancer than ever before to fully characterize the potential mutations driving disease.
Russia’s invasion of Ukraine created a dire situation for children with cancer and blood disorders. In response, the St. Jude Global initiative of St. Jude Children’s Research Hospital banded together with international partners and formed SAFER Ukraine. An account appears in The Lancet Haematology.
Scientists at St. Jude Children’s Research Hospital identified proteins that help decide T cell fate and used the finding to improve CAR-T cell therapy in a solid tumor model.
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right