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Released: 26-Feb-2018 11:05 AM EST
Decoding the Genome’s Dark Matter
Scripps Research Institute

These new areas of interest belong to the so-called “non-coding” genome—the 98 percent of the genome that doesn’t directly code for proteins but instead regulates how key proteins are produced.

   
Released: 21-Feb-2018 12:05 PM EST
Cross-Bred Flies Reveal New Clues About How Proteins Are Regulated
Scripps Research Institute

A team from The Scripps Research Institute (TSRI) has revealed that by crossing two species of flies, they can use what they learn from the proteome of the hybrid offspring to find new clues about how proteins interact with each other

Released: 20-Feb-2018 2:05 PM EST
TSRI Stroke Drug Demonstrates Safety in Clinical Trial
Scripps Research Institute

“These results lay the groundwork for the next steps toward FDA approval,” says John Griffin, PhD, professor at TSRI, whose team invented 3K3A-APC.

Released: 16-Feb-2018 4:05 PM EST
'Click Chemistry' Reactions May Boost Cancer-Fighting Drug Potency
Scripps Research Institute

Researchers at The Scripps Research Institute (TSRI) have developed a quick and easy way to simultaneously modify dozens of drugs or molecules to improve their disease-fighting properties.

   
Released: 15-Feb-2018 5:05 PM EST
TSRI Scientists Receive $15 Million to Study Viral Outbreak Survivors
Scripps Research Institute

The researchers will spend the next five years collecting data from Ebola and Lassa survivors to learn how they fought off the virus.

   
Released: 14-Feb-2018 3:35 PM EST
Scientists Find Key Proteins Control Risk of Osteoarthritis During Aging
Scripps Research Institute

A study from scientists at The Scripps Research Institute (TSRI) explains why the risk of osteoarthritis increases as we age and offers a potential avenue for developing new therapies to maintain healthy joints.

   
Released: 13-Feb-2018 6:05 PM EST
Heroin Vaccine Blocks Lethal Overdose
Scripps Research Institute

Scientists at The Scripps Research Institute (TSRI) have achieved a major milestone toward designing a safe and effective vaccine to both treat heroin addiction and block lethal overdose of the drug.

   
Released: 9-Feb-2018 12:05 PM EST
Microscopic Chariots Deliver Molecules Within Our Cells
Scripps Research Institute

Understanding how the dynein-dynactin complex is assembled and organized provides a critical foundation to explain the underlying causes of several dynein-related neurodegenerative diseases.

   
Released: 8-Feb-2018 12:05 PM EST
Scientists Take Big Step Toward Stopping Cancer Metastasis
Scripps Research Institute

TSRI scientists identify molecule that fuels cancer metastasis.

   
Released: 6-Feb-2018 11:05 AM EST
TSRI Receives $10 Million Grant to Study Effects of Alcohol on the Brain
Scripps Research Institute

The five-year grant will support five individual research projects and three core resources at the TSRI Alcohol Research Center.

   
Released: 22-Jan-2018 12:05 PM EST
TSRI Researchers Identify Gene Responsible for Mesenchymal Stem Cells’ Stem-Ness’
Scripps Research Institute

Scientists often struggle to predict how these cells will act in different environments in the body.

   
Released: 15-Jan-2018 11:05 AM EST
Scripps Translational Science Institute, Nature Research Launch Open-Access Digital Medicine Journal
Scripps Research Institute

Researchers from the Scripps Translational Science Institute (STSI) at The Scripps Research Institute (TSRI) have launched an open-access, peer-reviewed online journal—npj Digital Medicine.

10-Jan-2018 12:05 PM EST
Estrogen-Mimicking Compounds in Foods May Reduce Effectiveness of Breast Cancer Treatment
Scripps Research Institute

Scientists from The Scripps Research Institute have discovered that two estrogen-mimicking compounds found in many foods appear to potently reverse the effects of palbociclib/letrozole, a popular drug combination for treating breast cancer.

   
9-Jan-2018 5:05 PM EST
TSRI Scientists Discover Workings of First Promising Marburg Virus Treatment
Scripps Research Institute

Scientists at The Scripps Research Institute have discovered the workings of the first promising treatment for Marburg virus, a pathogen with the same pandemic potential as Ebola virus.

   
5-Jan-2018 5:05 PM EST
Chemists Discover Plausible Recipe for Early Life on Earth
Scripps Research Institute

Following the chemistry, scientists develop fascinating new theory for how life on Earth may have begun.

Released: 28-Dec-2017 12:05 PM EST
New Structure of Key Protein Holds Clues for Better Drug Design
Scripps Research Institute

Nobel laureate Kurt Wüthrich investigates the structure of an important drug target.

   
Released: 20-Dec-2017 4:55 PM EST
Researchers Get First Complete Look at Protein Behind Sense of Touch
Scripps Research Institute

The findings point the way to targeting diseases where this protein is mutated.

   
18-Dec-2017 12:05 PM EST
Dysfunctional Gene May Be Culprit in Some Crohn’s Disease Cases
Scripps Research Institute

The scientists hope understanding how immune cells adapt as they enter different tissues will spur the design of better, more specific, medicines.

   
Released: 18-Dec-2017 12:05 PM EST
Eric Topol Named Executive Vice President at the Scripps Research Institute
Scripps Research Institute

"Eric is an esteemed colleague with a clear vision for integrating scientific discovery and translational medicine."

15-Dec-2017 2:05 PM EST
‘Simple, But Powerful’ Model Reveals Mechanisms Behind Neuron Development
Scripps Research Institute

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have now uncovered new insights into the regulatory network behind neuron growth.

   
Released: 12-Dec-2017 11:05 AM EST
Jeffery Kelly Elected to National Academy of Inventors
Scripps Research Institute

Jeffery Kelly, Ph.D., co-chair of the Department of Molecular Medicine at The Scripps Research Institute (TSRI), has been named a fellow of the esteemed National Academy of Inventors (NAI), the organization announced today.

11-Dec-2017 1:05 PM EST
Blueprints for Anti-Cancer Drugs Discovered in Bacterial Genomes
Scripps Research Institute

New research suggests these hidden genes hold the blueprints for designing new, even more effective cancer-targeting compounds.

Released: 11-Dec-2017 12:05 PM EST
Scientists Discover Possible Master Switch for Programming Cancer Immunotherapy
Scripps Research Institute

How do killer T cells “learn” to leave their home base and amass within specific tissues like the skin, gut, and lung, or solid tumors?

6-Dec-2017 5:05 PM EST
The Structure of Cool
Scripps Research Institute

A team of researchers from The Scripps Research Institute (TSRI) and Duke University has made the first determination of the atomic structure of Transient Receptor Potential Melastatin 8 (TRPM8), a molecular sensor in nerve ends that detects cold temperatures as well as menthol and other chemicals that induce cold sensations.

   
Released: 30-Nov-2017 11:05 AM EST
The Scripps Research Institute Welcomes Renowned Data Scientist Amalio Telenti
Scripps Research Institute

Telenti is a leading data scientist and genomic researcher whose research foci include human genomics, as well as infectious disease research.

27-Nov-2017 4:05 PM EST
Scientists Create First Semi-Synthetic Organism that Stores and Retrieves Unnatural Information
Scripps Research Institute

This “semi-synthetic” strain of E. coli is the first to both contain unnatural bases in its DNA and use the bases to instruct cells to make a new protein.

Released: 21-Nov-2017 5:05 PM EST
To Forget or to Remember? Memory Depends on Subtle Brain Signals, Scientists Find
Scripps Research Institute

Understanding how brains actively erase memories may open new understanding of memory loss and aging, and open the possibility of new treatments for neurodegenerative disease.

   
16-Nov-2017 12:00 PM EST
Good Cells Gone Bad
Scripps Research Institute

A new study from The Scripps Research Institute (TSRI) is the first to show precisely how a process in nerve cells called the S-nitrosylation (SNO) reaction—which can be caused by aging, pesticides and pollution—may contribute to Parkinson’s disease.

   
15-Nov-2017 3:50 PM EST
New Painkillers Reduce Overdose Risk
Scripps Research Institute

The research shows that a range of compounds can deliver pain-blocking potency without affecting respiration.

   
Released: 15-Nov-2017 5:05 PM EST
A Structural Clue to Attacking Malaria’s ‘Achilles Heel’
Scripps Research Institute

New research could boost the development of a more potent vaccine against the global killer.

   
11-Nov-2017 5:05 AM EST
Potential New Autism Drug Shows Promise in Mice
Scripps Research Institute

NitroSynapsin is intended to restore an electrical signaling imbalance in the brain found in virtually all forms of autism spectrum disorder (ASD).

   
Released: 9-Nov-2017 4:05 PM EST
Ozanimod Successful in Clinical Trials for Multiple Sclerosis
Scripps Research Institute

Celgene Corporation recently announced results from two phase 3 trials evaluating the efficacy and safety of the drug ozanimod. Ozanimod was invented by scientists at The Scripps Research Institute (TSRI).

3-Nov-2017 3:30 PM EDT
Scientists Find Potential “Missing Link” in Chemistry That Led to Life on Earth
Scripps Research Institute

Chemists at The Scripps Research Institute (TSRI) have found a compound that may have been a crucial factor in the origins of life on Earth.

Released: 30-Oct-2017 12:05 PM EDT
How Flu Shot Manufacturing Forces Influenza to Mutate
Scripps Research Institute

Egg-based production causes virus to target bird cells, making vaccine less effective.

   
Released: 25-Oct-2017 12:05 PM EDT
New ResearchKit App Looks at How Genetic Risk Influences Heart Health Decisions
Scripps Research Institute

The MyGeneRank app allows individuals with genetic data from 23andMe to obtain an estimated genetic risk score for coronary artery disease.

Released: 25-Oct-2017 5:05 AM EDT
New Study: ‘Double Decker’ Antibody Technology Fights Cancer
Scripps Research Institute

Scientists from the Florida campus of The Scripps Research Institute have created a new class of antibody-drug conjugates for cancer therapy.

   
Released: 17-Oct-2017 12:05 PM EDT
New Research Opens the Door to ‘Functional Cure’ for HIV
Scripps Research Institute

Scientists have for the first time shown that a novel compound effectively suppresses production of the virus in chronically infected cells.

Released: 16-Oct-2017 11:05 AM EDT
TSRI’s Benjamin Cravatt Elected to National Academy of Medicine
Scripps Research Institute

A prominent and inventive chemical biologist, Cravatt’s research focuses on the role proteins play in cellular processes.

Released: 13-Oct-2017 12:05 PM EDT
Scientists Unveil ‘Roadmap’ to Aid Osteoporosis Treatment Development
Scripps Research Institute

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed a molecular model that may provide a new framework for improving the design of osteoporosis treatments.

Released: 13-Oct-2017 11:05 AM EDT
New Study Demonstrates Importance of Studying Sleep and Eating in Tandem
Scripps Research Institute

A new study from scientists on the Florida campus of The Scripps Research Institute (TSRI) offers important insights into possible links between sleep and hunger.

   
Released: 11-Oct-2017 4:40 PM EDT
TSRI Chemists Use Modified DNA Nucleotides to Create New Materials
Scripps Research Institute

Chemists at The Scripps Research Institute (TSRI) have demonstrate that they can repurpose DNA to create new substances with possible medical applications.

   
12-Sep-2017 12:05 PM EDT
TSRI Study Reveals New Clues to How a Successful HIV Vaccine Could Work
Scripps Research Institute

Scientists at The Scripps Research Institute (TSRI) have made a discovery that could speed efforts to develop a successful HIV vaccine.

   
11-Sep-2017 11:05 AM EDT
Outside-In Reprogramming: Antibody Study Suggests A Better Way to Make Stem Cells
Scripps Research Institute

Scientists at The Scripps Research Institute (TSRI) have found a new approach to the “reprogramming” of ordinary adult cells into stem cells.

   
17-Jun-2017 12:00 PM EDT
Firefly Gene Illuminates Ability of Optimized CRISPR-Cpf1 to Efficiently Edit Human Genome
Scripps Research Institute

Scientists on the Florida campus of The Scripps Research Institute (TSRI) have improved a state-of-the-art gene-editing technology to advance the system’s ability to target, cut and paste genes within human and animal cells—and broadening the ways the CRISPR-Cpf1 editing system may be used to study and fight human diseases. 

   
Released: 15-Jun-2017 2:05 PM EDT
Scripps Florida Scientist and Collaborators Win $7 Million Grant to Develop New ALS Treatments
Scripps Research Institute

Professor Matthew Disney of the Department of Chemistry on the Florida campus of The Scripps Research Institute (TSRI), together with scientists from Mayo Clinic’s Florida campus and Johns Hopkins School of Medicine, has been awarded $7.2 million from the National Institute of Neurological Disorders and Stroke of The National Institutes of Health to create new RNA-based treatments for the most common form of amyotrophic lateral sclerosis (ALS), as well as a type of frontotemporal dementia (FTD).

Released: 14-Jun-2017 6:05 PM EDT
Influenza Virus Can Overcome Potentially Crippling Mutations
Scripps Research Institute

Scientists at The Scripps Research Institute (TSRI) have shown that for the virus that causes the flu, two wrongs can sometimes make a right.

   
Released: 12-Jun-2017 4:05 PM EDT
Scientists Solve a Mystery in Cellular “Droplet” Organelles
Scripps Research Institute

The new research may have important implications for fundamental biology and diseases like ALS.

   
Released: 6-Jun-2017 12:05 PM EDT
Anti-Heroin Vaccine Found Effective in Non-Human Primates
Scripps Research Institute

This is the first vaccine against an opioid to pass this stage of preclinical testing.

   


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