An international team of researchers supported by the National Institutes of Health has blocked staph infections in mice using a drug previously tested in clinical trials as a cholesterol-lowering agent. The novel approach, described in the February 14 online edition of Science, could offer a new direction for therapies against a bacterium that's becoming increasingly resistant to antibiotics.
Our alarm clocks may spring forward on March 9, but our biological clocks may take longer to adjust. That's because our internal clocks are so tightly wound to many physiological and behavioral processes. Researchers have made remarkable strides in identifying genes and neural pathways involved in regulating our internal clocks, and such advances could lead to new treatments for insomnia, jet lag, depression, obesity, and other disorders.
On February 12, groups worldwide will celebrate the birthday of Charles Darwin, the scientist who documented evolution through natural selection nearly 150 years ago. Today, Darwin's groundbreaking work on the origin of species forms the basis of modern evolutionary biology and is at the heart of biomedical research.
Scientists have identified a new factor necessary for influenza viruses to infect the human upper respiratory tract"”a necessary step for sustaining spread between people. The research offers additional insight into how the H5N1 avian flu virus currently circulating in birds would have to change in order to gain a foothold in human populations.
A newly released software program will let health authorities at the site of an infectious disease outbreak quickly analyze data, speeding the detection of new cases and the implementation of effective interventions.
If you ever had a set of Micronauts "“ toy robots with removable body parts "“ you probably had fun swapping their heads, imagining how it would affect their behavior. Scientists supported by the National Institutes of Health have been performing similar experiments on ion channels "“ pores in our nerve cells "“ to sort out the channels' key functional parts.
More than 40 years after beta blockers were first used clinically, scientists can finally get a detailed, three-dimensional look at the drugs' molecular target"”the beta2-adrenergic receptor. This receptor hails from a family of proteins called G protein-coupled receptors (GPCRs) that control critical bodily functions, several of our senses, and the action of about half of today's pharmaceuticals.
Free science educational materials produced by the National Institute of General Medical Sciences, a component of the National Institutes of Health, help students and teachers better understand and appreciate the life sciences.
Huntington's disease, an inherited neurodegenerative disorder that affects roughly 30,000 Americans, is incurable and fatal. But a new discovery about how cells repair their DNA points to a possible way to stop or slow the onset of the disease. The research was funded by the National Institutes of Health (NIH).
One of the persistent riddles of the deadly 1918 Spanish influenza pandemic is why it struck different cities with varying severity. Why were some municipalities such as St. Louis spared the fate of the hard-hit cities like Philadelphia when both implemented similar public health measures? What made the difference, according to two independent studies.
An international team of researchers is using computers to prepare for a possible pandemic influenza, a type of flu that could infect millions of people worldwide.
Sepsis is the second leading killer in the ICU. A 5-year grant of more than $8.4 million will nationally test the first set of standard procedures to diagnose and treat sepsis in emergency departments.
Burns. Diabetic ulcers. Gunshot wounds. Bedsores. The treatment of these and other wounds may improve, thanks to a new $13 million NIH initiative to develop innovative therapies for acute and chronic wounds. The goal of this interdisciplinary effort is to deepen understanding of wound healing and apply this knowledge to enhance treatment.
Activities that heat up summer fun also can bring risks, including severe burns and other forms of trauma. Researchers supported by the National Institute of General Medical Sciences, part of the National Institutes of Health, have made remarkable advances in both the basic understanding and treatment of these injuries.
A team of scientists and surgeons is developing a series of standard procedures for the care of severely injured patients. The clinical guidelines aim to improve patient care and to help the team identify genetic factors that correlate with particular outcomes.
New research from scientists at the Harvard School of Public Health in Boston and the University of Washington in Seattle suggests that containment can buy time to prepare, but containment alone is not enough to stop a flu pandemic from occurring.
Four new scientific teams joined an international research network developing computer-based simulations of pandemic flu and other infectious disease outbreaks. The results could aid health officials and policymakers in developing preparedness plans for outbreaks that occur naturally or deliberately.
The National Institutes of Health named 13 new recipients of the NIH Director's Pioneer Award, which supports exceptionally creative scientists who take innovative approaches to major challenges in biomedical research. The new awardees will receive $500,000 in direct costs per year for five years.
A carefully chosen combination of public health measures, if implemented early, could stop the spread of an avian flu outbreak at its source, suggest two international teams of researchers.
Millions of people take the anticoagulant drug warfarin to prevent harmful clotting after a heart attack, stroke, or major surgery. But the proper dose of warfarin can vary greatly and can be hard to predict. Some of this variability may boil down to a recently identified gene involved in blood clotting, according to a new study.
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