Researchers comparing several clonal strains of isoniazid-sensitive and resistant tuberculosis bacteria found shared changes to mycobacterial metabolism that bolster the evidence for a new proposed drug target.
The journal Molecular & Cellular Proteomics has released draft guidelines for reporting studies that use DIA-MS proteomics. The guidelines will help authors report enough information on this new method to make their work interpretable and reproducible.
New research from several universities in Germany, to be published in the Journal of Biological Chemistry, suggests that it may be easier than anticipated to find a compound that could be used as a food supplement to stop the spread of norovirus in children's hospitals.
Phospholipases are enzymes that cleave the tail group off of phospholipids, which make up cell membranes. These tails, or free fatty acids, can go on to act as signaling molecules. Lysosomal phospholipase A2, or LPA2, is a phospholipase from the macrophages that protect the lung.
People with chronic kidney disease are at unusually high risk of also developing cardiovascular disease; in fact, a patient with non-dialysis kidney disease is more likely to die of heart failure than to develop end-stage kidney failure. However traditional atherosclerosis risk factors contribute less strongly to cardiovascular disease in chronic kidney disease patients than in subjects with intact kidney function.
Recent articles in the journal Molecular & Cellular Proteomics investigate metabolic quirks of cancer cells, other roles for the enzyme that generates amyloid beta, and the action mechanism of a bacterial toxin.
The American Society for Biochemistry and Molecular Biology has launched a program that will train scientists and science students to communicate with lawmakers and advocate for sound science policies.
The American Society for Biochemistry and Molecular Biology this week named a dozen scientists the winners of its annual awards. The winners were nominated by colleagues and other leaders in their fields for making significant contributions to biochemistry and molecular biology and the training of emerging scientists.
In recent articles in Molecular & Cellular Proteomics, scientists optimize experimental design for understanding potential chemotherapeutic agents, delve into crop responses to salt-water stress, and present a better way to ensure consistency in long-term proteomics studies.
Recent articles in the Journal of Lipid Research investigate how brown fat whitening causes inflammation, how cells in the liver fill lipid droplets, and how ketogenic and restricted-calorie diets affect metabolites in a mouse.
Researchers at Brazil's largest producer of antivenoms report a structural analysis of glycans modifying venom proteins in several species of lancehead viper. The snakes are among the most dangerous in South America. The report offers insight into the solubility and stability of toxic proteins from venom, and into how venoms from different species vary. Scientists are now working to map glycan structures back onto the proteins they modify.
Routine tests couldn't diagnose an Israeli infant's developmental disorder. Until they completed whole-exome sequencing, his doctors were stumped. After finding a homozygous rare allele, they teamed up with Japanese experts on the affected enzyme to describe its role in myelination in a paper in the June issue of the Journal of Lipid Research.
In a paper to be published in the June 1 issue of the Journal of Biological Chemistry, researchers at Washington University in St. Louis provide the first report of an enzyme that breaks down plasmalogens, a breakthrough in understanding the molecular processes that occur during Alzheimer’s and other diseases.
French researchers have developed a device that painlessly ionizes the top few microns of skin for analysis by mass spectrometry. The device is being tested to make surgery more efficient in pet dogs with sarcoma.
Recent articles in the Journal of Lipid Research found a surprising insight into healthy octogenarians’ arteries; a microRNA key to the puzzle of killing fat cells; and a change in cultured cell signaling that may affect experimental outcomes.
Recent studies in the journal Molecular & Cellular Proteomics have shed light on pathogenic mechanisms of the sexually-transmitted parasite Trichomonas vaginalis and the HIV-associated opportunistic lung fungus Aspergillus.
A genomic analysis of a large study population has identified uncommon gene variants involved in responses to dietary fats and medicine. Although these variants are rare, they may play a large role in a carrier's risk of heart disease.
This month’s issue of the journal Molecular & Cellular Proteomics features research using novel proteomics methods to address unanswered questions in cancer research, including protein variation within tumors; the failure of a candidate cancer drug; and how a chemotherapeutic combination acts synergistically.
This month’s issue of the Journal of Lipid Research features studies examining how fats in the diet affect health, including whether the ketogenic diet is a reasonable cancer therapy; how the type of unsaturated fats in a mouse’s chow affects inflammation; and how cells respond to nutrient signals.
The American Society for Biochemistry and Molecular Biology is pleased to announce the winners of its annual awards, and the times and titles of their talks at ASBMB 2018 in San Diego in late April.
Researchers at Harvard Medical School, the University of California, San Francisco, and the University of Georgia have described how the protein that allows strep and staph bacteria to stick to human cells is prepared and packaged. The research, which could facilitate the development of new antibiotics, will appear in the April 6 issue of the Journal of Biological Chemistry.
The 2018 ASBMB Annual Meeting in San Diego will feature talks by winners of the Journal of Biological Chemistry/Herbert Tabor Young Investigator Awards, on April 22.
Cells can avoid “data breaches” when letting signaling proteins into their nuclei thanks to a quirky biophysical mechanism involving a blur of spaghetti-like proteins, researchers from the Rockefeller University and the Albert Einstein College of Medicine have shown. Their study appears in the March 23 issue of the Journal of Biological Chemistry.
The Journal of Biological Chemistry has appointed Phyllis Hanson, Karin Musier-Forsyth, and Michael Shipston as associate editors. The three new editors bring expertise in intracellular cell membranes, RNA biology, and ion channel signaling to the journal.
Research Highlights: a proteomics study to understand a rare skin disease; understanding T cell activation through "click chemistry."
Researchers at Iowa State University, partnering with the LifeServe Blood Center, have used leftover blood donor cells to gain crucial insights into how natural killer cells circulating in the human body differ from those typically studied in the lab. The results of this research are published in the March 9 issue of the Journal of Biological Chemistry.
A lotion inspired by babies’ skin, membrane binding by an inflammation-linked kinase, and a colorectal cancer-fighting microRNA.
Researchers at Durham University in the UK have identified a crucial link in the process of how plants regulate their antiviral responses. The research is published in the March 2 issue of the Journal of Biological Chemistry.
New research published in the Feb. 23 issue of the Journal of Biological Chemistry identifies an enzyme that turns off transglutaminase 2, potentially paving the way for new treatments for celiac disease.
NIH researchers studying a fatal childhood illness called Sandhoff disease uncover new details about how it develops in utero that indicate gene therapy has potential.
Researchers studying half-lives of evolutionarily related proteins in different species uncovered a link between species lifespan and protein lifespan.
Cholesterol in muscular dystrophy; synergy between alcohol and hepatitis in cholesterol levels; bacterial lipids in healthy arteries.
Researchers at the University of Georgia have now shown that the enzyme that makes the El Tor family of V. cholerae resistant to those antibiotics has a different mechanism of action from any comparable proteins observed in bacteria so far. Understanding that mechanism better equips researchers to overcome the challenge it presents in a world with increasing antibiotic resistance. The results of this research are published in the Dec. 22, 2017 issue of the Journal of Biological Chemistry.
Researchers at the California Institute of Technology have developed an approach to overcome a major stumbling block in testing new drug targets. The research is reported in a Nov. 24 paper in the Journal of Biological Chemistry.
Qi-Qun Tang, a professor of in the department of biochemistry and molecular biology at the Fudan University School of Basic Medical Sciences in Shanghai, China, has joined the Journal of Biological Chemistry as an associate editor.
A research project that began 20 years ago with an interest in how lithium treats mood disorders has yielded insights into the progression of blood cancers such as leukemia. The research, which centers on a protein called GSK-3, will be published in the Nov. 3 issue of the Journal of Biological Chemistry.
In an opinion piece in the journal eLife, eight scientists and science policy experts make the case for standardizing how postdoctoral researchers are categorized by human resources offices and provide a framework that willing institutions can follow.
Ursula Jakob, a professor of biological chemistry at the University of Michigan, has joined the Journal of Biological Chemistry as an associate editor.
New research from the Korea Institute of Science and Technology, to be published in the Journal of Biological Chemistry on Oct. 13, has found that the proteasome, an essential protein complex that breaks down proteins in cells, has another unexpected function: directly regulating the packing of DNA in the nucleus.
New insight into how the protein antithrombin works could lead to treatments not only for patients with antithrombin deficiency, but also to better-designed drugs for other blood disorders.
Researchers at Thomas Jefferson University studying combinations of drugs against HIV have discovered why certain drugs sometimes act synergistically but sometimes do not.
A study to be published in the September 29 issue of the Journal of Biological Chemistry reports the use of an emerging method to identify proteins that allows two organelles, the mitochondria and the endoplasmic reticulum, to attach to each other.
The proteins in human cells are extensively decorated with different types of sugars, a phenomenon called glycosylation. These modifications greatly increase the diversity of protein structure and function, affecting how proteins fold, how they behave, and where they go in cells. New research that will be published in the Journal of Biological Chemistry on Sept. 22 demonstrates that a rare type of glycosylation profoundly affects the function of a protein important for human development and cancer progression.
A toxin produced by a bacterium that causes urinary tract infections is related to, yet different in key ways from, the toxin that causes whooping cough, according to new research. The findings, which will be published in the Sept. 8 issue of The Journal of Biological Chemistry, could aid in the development of new vaccines.
A group of researchers has developed an approach to efficiently produce antibodies that can bind to two different target molecules simultaneously, a long-desired innovation in the field of cancer immunotherapy. The details will be published in the Sept. 1 issue of the Journal of Biological Chemistry.
A little-studied gene may explain how some liver cancer cells obtain the nutrition they need to proliferate, according to new research from the University of Maryland.
Researchers at the University of Pennsylvania have developed a set of tools to observe, monitor and quantify how misfolded proteins associated with Parkinson’s disease enter neurons in laboratory cultures and what happens to them once they’re inside.
The American Society for Biochemistry and Molecular Biology announced this week the election and appointment of seven new society leaders. They begin their terms July 1.
Young scientists from colleges and universities across the United States will arrive on Capitol Hill on Thursday to talk with senators and representatives about the value of biomedical research.
Winter is in full swing, and many of us have fantasized about curling up in a warm cave and slumbering until the warmth of spring arrives, just like a bear. Bears have the ability to sleep away the harsh winter months when food is scarce. They can spend five to seven months in hibernation. During this time, bears do not eat, drink, excrete or exercise. Despite the length of inactivity, bears do not experience bone loss, muscle loss, heart complications or blood clots like humans do during extended bouts of inactivity.
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