• Among veterans with acute kidney injury (AKI) at some point between 2008 to 2017, 6% died in-hospital and 28% died within 1 year. In contrast, in-hospital and one-year mortality was 0.8% and 14%, respectively, among non-AKI hospitalizations. • In veterans hospitalized with AKI, in-hospital and one-year mortality rates remained stable throughout the study period.
• At the start of a study of older adults with advanced kidney disease, women had lower average physical and mental health-related quality-of-life scores compared with men. • Over time, however, both physical and mental scores declined approximately twice as fast in men than in women.
• In an analysis of data from a recent clinical trial, researchers found that removing a race-based adjustment in the estimation of individuals’ kidney function had a small but potentially important impact on the inclusion of participants, with differing effects on Black and non-Black participants. • Removal of the race-based adjustment also influenced inclusion parameters such as participants’ severity of kidney function impairment at baseline as well as their risk of developing cardiovascular- and kidney-related outcomes.
Survey results indicate that there’s a global shortage of dietitians to provide kidney nutrition care, and many patients with kidney disease who need nutritional interventions either do not receive them or receive suboptimal therapy with inadequate monitoring.
Kidney transplants from deceased donors function for a median of 10 to 15 years. New research indicates that when a kidney transplant fails, retransplantation may offer better survival patients compared with undergoing dialysis.
• New research indicates that many kidney transplant recipients may not be adequately protected against emerging SARS-CoV-2 variants with the standard COVID-19 vaccination regimens currently used in the healthy general population.
• Survey results indicate that acute kidney injury (AKI) has significant impacts on individuals’ physical and emotional health, as well as on their work and family life. • Only about half of respondents rated medical team communication about AKI as very/extremely good.
• Video-based telemedicine is used to facilitate care across all stages of chronic kidney disease. • Video-based telemedicine has evolved in recent years to be less reliant on specialized equipment and has allowed patients to receive kidney care in a location of their choice. • Further work is needed on approaches to sustainable integration and minimizing barriers to access.
Individuals with kidney failure who were on dialysis had an incomplete and delayed antibody response and a blunted cellular immune response following COVID-19 vaccination, compared with people with normal kidney function.
• Taking sodium-glucose cotransporter 2 inhibitors was linked with lower risks of developing cardiovascular disease and kidney failure among patients with type 1 diabetes when using prediction models called the Steno Type 1 Risk Engines. • Results from the study will be presented online at ASN Kidney Week 2021 November 4–November 7.
• People who are on dialysis or who have undergone kidney transplantation have immune system–related differences compared with people with normal kidney function, and these differences are further amplified by SARS-CoV-2 infection. • The findings may help explain why these individuals face a higher risk of dying from COVID-19. • Results from the study will be presented online at ASN Kidney Week 2021 November 4–November 7.
• Results from a recent clinical trial indicate that the diabetes drug dapagliflozin slows kidney function decline in patients with chronic kidney disease, regardless of whether they have diabetes. • Results from the study will be presented online at ASN Kidney Week 2021 November 4–November 7.
The results of numerous high-impact clinical trials that could affect kidney-related medical care will be presented online at ASN Kidney Week 2021 November 4–November 7.
Today, the American Society of Nephrology (ASN) announced the Barbara T. Murphy Endowed Lectureship. Established by Verici Dx (LSE: VRCI), Renalytix (LSE RENX and Nasdaq RNLX), and the American Society of Transplantation (AST), the new lectureship will honor Dr. Murphy’s legacy as a leader in transplant immunology and medicine by recognizing advances in kidney transplantation.
• Among adults with hypertension, air pollution exposure was not linked with blood levels of Galectin 3, a marker of scarring in the heart; however, in adults who also had chronic kidney disease, air pollution exposure was associated with rising levels of Galectin 3. • Results from the study will be presented online at ASN Kidney Week 2021 November 4–November 7.
• Investigators found that the Kidney Disease Risk Equation can predict a patient’s likelihood of developing chronic kidney disease, based on readily available information. • Results from the study will be presented online at ASN Kidney Week 2021 November 4–November 7.
• New research indicates that substantial discrepancies exist between eGFR and mGFR, which are different assessments of kidney function, even in an individual patient. • Results from the study will be presented online at ASN Kidney Week 2021 November 4–November 7.
• Among hospitalized patients, a diagnosis of acute kidney injury was linked to worse patient outcomes after hospital discharge. • Results from the study will be presented online at ASN Kidney Week 2021 November 4–November 7.
• Among adults undergoing cardiac surgery, those who took proton pump inhibitors before surgery were more likely to develop acute kidney injury and to die during hospitalization. • Results from the study will be presented online at ASN Kidney Week 2021 November 4–November 7.
• Certain factors may explain why men are more likely than women to develop kidney stones. • The gap between men and women in terms of risk of stones is getting smaller. • Results from the study will be presented online at ASN Kidney Week 2021 November 4-November 7.
• Researchers have identified several metabolites in the blood whose levels are altered by coffee consumption. • Levels of 3 of these coffee-related metabolites were significantly associated with individuals’ risk of developing chronic kidney disease.
In a study of children on the U.S. kidney transplant list from 2008 to 2019, researchers found no racial and ethnic disparities regarding time on the waitlist until transplantation either before or after a 2014 policy change.
Chronic kidney disease (CKD) is a global health crisis with an estimated 850 million affected individuals. The State of the Global Nephrology Workforce: A Joint ASN–ERA-EDTA–ISN Investigation addresses whether there are enough kidney doctors—or nephrologists available to care for the growing number of people around the world with CKD, and whether their training is adequate. The investigation was conducted by the American Society of Nephrology (ASN), European Renal Association (ERA), and International Society of Nephrology (ISN).
Clinical equations that estimate patients’ kidney function include an adjustment for Black race. This survey-based study found that U.S. transplant centers agree that this adjustment is unsatisfactory.
During 2015–2021, Medicare implemented an initiative that offered financial incentives for enhanced care coordination and patient outcomes among providers treating Medicare beneficiaries with kidney failure.
Patients with kidney failure who were affected by dialysis facility closures between 2001 and 2014 experienced 7% to 9% higher rates of hospitalizations compared with similar patients at facilities that did not close.
A recent study examined the spectrum of antibody responses—including IgG, IgM, and IgA antibodies—in kidney transplant recipients infected with the virus that causes COVID-19
An analysis of national data shows that kidney transplant recipients and individuals with kidney failure face a high risk of dying from COVID-19.
Today, the National Kidney Foundation (NKF) and the American Society of Nephrology (ASN) Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Diseases has released its final report, which outlines a new race-free approach to diagnose kidney disease.
Today, advocates of the American Society of Nephrology (ASN) and 19 other kidney health professional and patient organizations are meeting with their congressional delegations, calling on them to enact policies to improve kidney health
Most surveyed family members of patients with kidney failure on long-term dialysis reported they had spoken with the patient about their end-of-life wishes but not about stopping dialysis or initiating hospice.
• The Patient Activation Measure describes an individual’s knowledge, ability, skills, and confidence in self-managing chronic conditions. • A recent study examined the measure’s relevance for patients with kidney failure who are undergoing long-term dialysis.
The National Kidney Foundation (NKF) and the American Society of Nephrology (ASN) congratulate the NKF-ASN Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Diseases for submitting its final report for publication.
• In individuals with kidney disease, those with high body mass index variability faced higher risks of needing kidney replacement therapy, experiencing a heart attack, experiencing a stroke, and dying prematurely.
• Pooled results from phase 3 clinical trials demonstrate that roxadustat is efficacious and may be comparable to placebo in studies done to date for treating anemia in patients with chronic kidney disease who do not require dialysis.
• In a clinical trial of individuals at high risk for developing type 2 diabetes, which is the leading cause of kidney disease, vitamin D supplementation did not have significant effects on kidney health. • As participants were not selected according to baseline vitamin D levels, investigators cannot exclude a kidney benefit for individuals with vitamin D deficiency.
• Removal of race adjustments to equations that estimate kidney function would increase the number of people categorized as having chronic kidney disease. • There are several modifications for removing race that vary in their expected impact on predicted kidney function values and associated clinical decisions. • Among race-free equations, the one based on blood measurements of cystatin C would likely result in the smallest changes.
• After kidney transplantation, natural killer cells of the recipient become active because they miss “self” proteins on donor cells. • These cells contribute to organ rejection, in addition to traditional modes of rejection involving T cells and antibodies.
• The sodium-glucose co-transporter 2 inhibitor dapagliflozin reduced kidney, cardiovascular, and mortality risks in patients with advanced chronic kidney disease, similar to benefits seen in individuals with normal or moderately impaired kidney function. • Rates of serious side effects were similar in patients with advanced chronic kidney disease who received dapagliflozin or placebo.
Highlights • The results of a new study support the validity of a score that considers various patient-reported outcome measures and preferences for assessing health-related quality of life in individuals with kidney failure. • The score is calculated from assessments of cognitive function, depression, fatigue, pain interference, physical functioning, sleep disturbance, and ability to participate in social roles
• In this analysis of U.S. adults with advanced kidney disease, even low levels of lead in community drinking water had a negative effect on health. • Higher lead levels were found in the drinking water of predominantly Black communities compared with predominantly white communities.
• The physician-scientist workforce doing kidney research in the United States is increasingly made up of women and international medical graduates. • However, this workforce is older, declining in relative number, and is less overwhelmingly focused on basic rather than clinical science.
• Patients with kidney failure did not report better experience with care from more frequent face-to-face visits with kidney specialists at dialysis facilities. • In fact, more frequent visits were linked with slightly lower patient-reported experiences with kidney-related care.
• Among individuals with chronic kidney disease, iron deficiency was linked with higher risks of death and cardiovascular events, in patients with and without anemia. • Clinical trials are needed to test the effects of iron treatment, even in the absence of anemia, in patients with chronic kidney disease.
KidneyCure (the ASN Foundation) is honored to continue its support of investigators committed to advancing kidney health. Building on decades of success, KidneyCure makes it possible to improve knowledge and treatment by identifying and funding high-impact projects.
• In a study of patients waiting for a kidney transplant, those who experienced various symptoms had a higher risk of dying while on the waitlist. • Symptoms tended to increase or remain unchanged between transplant evaluation and transplantation; however, at 3 months after transplantation, 9 of 11 symptoms lessened.
• Primary nephrotic syndrome is characterized by high urinary excretion of protein, low protein in the blood, high cholesterol, and swelling in the arms and legs. • A new analysis highlights the high risk of kidney failure and different cardiovascular complications in patients with primary nephrotic syndrome.
• Among U.S. adults with kidney failure, many of those who have the longest expected post-transplant survival are not being placed on the kidney transplant waiting list. • African Americans, patients lacking commercial health insurance, and those residing in lower income communities are less likely to be waitlisted.
• The five-year innovative pilot program offers financial support for trainees entering the field of nephrology, focusing on individuals historically underrepresented in medicine. • Six candidates selected in the first year of the program will each receive $50,000 over the course of three years toward the repayment of eligible student loans.
• The virus that causes COVID-19 can infect and replicate in human kidney cells, but this does not typically lead to cell death. • Kidney cells that already have features of injury may be more easily infected and develop additional injury.
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