Johns Hopkins Medicine scientists say they have developed a nanoparticle — an extremely tiny biodegradable container — that has the potential to improve the delivery of messenger ribonucleic acid (mRNA)-based vaccines for infectious diseases such as COVID-19, and vaccines for treating non-infectious diseases including cancer.
For the first two weeks of life, mice with a hereditary form of deafness have nearly normal neural activity in the auditory system, according to a new study by Johns Hopkins Medicine scientists. Their previous studies indicate that this early auditory activity — before the onset of hearing — provides a kind of training to prepare the brain to process sound when hearing begins.
In a study that followed more than 2,000 community-dwelling older adults over eight years, researchers at Johns Hopkins Medicine say they have significant new evidence of a link between decreased sense of smell and risk of developing late-life depression.
Clinicians have a new standard for graft-versus-host disease (GVHD) prevention after allogeneic hematopoietic stem cell transplantation, according to results from a phase III study published in the New England Journal of Medicine. The new standard is more effective at preventing GVHD and came with less side effects, compared with the current gold standard.
In an eight-year study of more than 600 community-dwelling older adults, Johns Hopkins Medicine researchers say they have further linked levels of cell-free DNA (DNA fragments resulting from cell death) circulating in the blood to chronic inflammation and frailty.
A Johns Hopkins Children Center study using medical records from an international registry concludes that female babies with congenital diaphragmatic hernia (CDH) are slightly more likely to die within 30 to 60 days of birth than male babies with the same condition.
Hispanic and non-Hispanic Black female survivors of breast cancer experience higher death rates after being diagnosed with a second primary cancer than members of other ethnic and racial groups, according to recent research from investigators at the Johns Hopkins Kimmel Cancer Center.
The percentage of survivors of cancer reporting functional limitations in the United States has more than doubled over the past 20 years, according to a new study in the journal JAMA Oncology. The work, published May 11, was a collaborative effort from investigators at the Johns Hopkins Kimmel Cancer Center, the Dell Medical School in Austin, Texas, and the University of Minnesota’s Masonic Cancer Center in Minneapolis.
Johns Hopkins scientists have developed a method involving artificial intelligence to visualize and track changes in the strength of synapses — the connection points through which nerve cells in the brain communicate — in live animals. The technique, described in Nature Methods, should lead, the scientists say, to a better understanding of how such connections in human brains change with learning, aging, injury and disease.
According to the federal government’s National Institute of Neurological Disorders and Stroke, nearly 3 million people worldwide — with almost a third in the United States — are living with multiple sclerosis (MS), a disabling neurological disease in which the body’s immune system mistakenly attacks nerves feeding information to the central nervous system (the brain and spinal cord). Although rarely fatal, MS can lead to long-term disabilities, and impair movement, muscle control, vision and cognition.
In a recent study, a Johns Hopkins Medicine researcher and collaborators analyzed data on adults to determine if there is a link between having a heart attack and cognitive decline.
Scientists have spent years trying to develop an effective HIV vaccine, but none have proven successful. Based on findings from a recently published study, a Johns Hopkins Medicine-led research team may have put science one step closer to that goal.
Researchers at Wilmer Eye Institute, Johns Hopkins Medicine say they have evidence that an experimental drug may prevent or slow vision loss in people with diabetes. The results are from a study that used mouse as well as human retinal organoids and eye cell lines.
Wilmer Eye Institute, Johns Hopkins Medicine researchers say they have used artificial intelligence models and machine-learning algorithms to successfully predict which components of amino acids that make up therapeutic proteins are most likely to safely deliver therapeutic drugs to animal eye cells.
SpaceMarkers, a new machine learning software developed by researchers at the Johns Hopkins Convergence Institute and the Johns Hopkins Kimmel Cancer Center, can identify molecular interactions among distinct types of cells in and around a tumor.
Osteoporosis — a condition that causes bones to become weak and more susceptible to fracture — affects more than 10 million Americans. It occurs when a person’s body does not properly replenish the components of their bone tissue.
Hepatitis is inflammation of the liver, anorgan that helps digest food and remove toxins from the body. This condition is most commonly caused by viral infection, and many cases clear up within a few months. However, according to the National Institutes of Health, chronic hepatitis — cases that last six months or longer — affects approximately 4.4 million Americans.
With a $35 million gift from researcher, philanthropist and race car driver Theodore Giovanis, scientists at Johns Hopkins Medicine will study the biological roots of the most fatal aspect of cancer: how it metastasizes, or spreads, through the body.
According to a new Johns Hopkins Medicine study, low pain self-efficacy can predict daily pre-surgery prescribed opioid use among patients seeking elective spine surgery.
In a study of 17 people from five families, Johns Hopkins Medicine researchers say they found that ultra-lengthy DNA endcaps called telomeres fail to provide the longevity presumed for such people. Instead, people with long telomeres tend to develop a range of benign and cancerous tumors, as well as the age-related blood condition clonal hematopoiesis.
Johns Hopkins Children’s Center researchers will present on numerous topics during the PAS 2023 meeting.
Researchers at Johns Hopkins University School of Medicine say they have evidence from a new study in rats that spinal cord stimulation (SCS) may be useful in reducing chronic pain in people undergoing active treatment with a common anti-cancer drug.
Among families with children diagnosed with autism spectrum disorder, Johns Hopkins University researchers say they have found a link between chemical “marks” on DNA in the sperm of fathers and autistic traits in their 3-year-old children.
Johns Hopkins University researchers have found that traumatic brain injuries (TBIs) were the second most common injury among adults treated in U.S. emergency rooms for injuries related to walking a leashed dog from 2001 to 2020.
Researchers at the Johns Hopkins Kimmel Cancer Center identified a novel cell signaling pathway that potentially could be targeted in therapy for patients with aggressive pancreatic cancers.
A new study by researchers at the Johns Hopkins Kimmel Cancer Center in collaboration with Dell Medical School, University of Minnesota, and the Vanderbilt University Medical Center, using a national data sample from the National Institutes of Health All of Us Research Program, revealed that a small but statistically significant proportion of patients with cancer, especially younger and lower-income minorities, disproportionately reported delaying care because of patient/clinician racial, gender and cultural differences.
Every year, millions of people in the U.S. are diagnosed with sexually transmitted infections (STIs), which are infectious diseases spread through sexual contact. Infection rates are particularly high in young people, with half of new cases occurring in people between 15 and 24 years old.
Dopamine, a brain chemical long associated with pleasure, motivation and reward-seeking, also appears to play an important role in why exercise and other physical efforts feel “easy” to some people and exhausting to others, according to results of a study of people with Parkinson’s disease led by Johns Hopkins Medicine researchers. Parkinson’s disease is marked by a loss of dopamine-producing cells in the brain over time.
A new drug, a monoclonal antibody known as enoblituzumab, is safe in men with aggressive prostate cancer and may induce clinical activity against cancer throughout the body, according to a phase 2 study led by investigators at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy.
The number of immune cells in and around kidney tumors, the amount of dead cancer tissue, and mutations to a tumor suppressor gene called PBRM1 form a biomarker signature that can predict — before treatment begins — how well patients with kidney cancer will respond to immunotherapy, according to new research directed by investigators at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy.
At age 17, Sara Kathryn Smith began an unexpected, personal health journey — a journey that would alter the course of her life and career and, ultimately, provide her a unique set of experiences to help others as a medical professional. Today, Smith serves as the medical director for pediatric liver transplantation at Johns Hopkins Children’s Center. But years ago, she was a liver transplant patient herself.
In a new study looking at the long-term effects of hospitalized patients who have acute kidney injury (AKI), a sudden but temporary loss of kidney function, Johns Hopkins Medicine researchers found that higher levels of certain biomarkers in urine and blood can predict a patient’s risk of developing chronic kidney disease (CKD).
Johns Hopkins Medicine scientists say their 20-year study of more than 200 people with premature aging syndromes caused by abnormally short telomeres, or shortened repetitive DNA sequences at the ends of chromosomes, may upend long-held scientific dogma and settle conflicting studies about how and whether short telomeres contribute to cancer risk.
Johns Hopkins Medicine Hosts In-Person Black Men in White Coats Youth Summit
As part of the worldwide effort to facilitate a research and clinical pathway toward successful xenotransplantation — the transplantation of living cells, tissues and organs from one species to another — two Johns Hopkins Medicine surgeons, Kazuhiko Yamada, M.D., Ph.D., and Andrew Cameron, M.D., Ph.D., will receive a total of $21.4 million in funding over the next two years under two sponsored research agreements with biotechnology company United Therapeutics Corporation.
To develop treatments that may one day entirely rid the body of HIV infection, scientists have long sought to identify all of the places that the virus can hide its genetic code. Now, in a study using blood samples from men and women with HIV on long-term suppressive therapy, a team led by Johns Hopkins Medicine scientists reports new evidence that one such stable reservoir of HIV genomes can be found in circulating white blood cells called monocytes.
The breast tumors of Asian, Black and white women have very different cellular, microbial and genomic features that could potentially be used to personalize care or predict disease progression, according to new research by investigators at the Johns Hopkins Kimmel Cancer Center.
Spring has arrived. The new season is bringing budding trees and blossoming flowers, along with runny and stuffy noses, sneezes and itchy, watery eyes.
In experiments with mice and humans, a team led by Johns Hopkins Medicine researchers says it has identified a particular intestinal immune cell that impacts the gut microbiome, which in turn may affect brain functions linked to stress-induced disorders such as depression.
For some people receiving methadone for treatment of opioid use disorder (OUD), the co-use of opioids and stimulants such as cocaine is an issue. Now, a new study led by Johns Hopkins Medicine researchers found that bupropion, an antidepressant medication also used for smoking cessation, may help people stop using cocaine while in treatment for OUD.
The Acute Hospital Rehabilitation Intensive Service (ARISE) program, developed in 2020 by the Johns Hopkins Department of Physical Medicine and Rehabilitation (PM&R), may increase the chances of patients hospitalized with COVID-19 getting discharged to their home rather than to a rehabilitation facility that provides post-hospitalization care services.
Johns Hopkins Medicine researchers are collaborating with NASA to send human heart “tissue-on-a-chip” specimens into space as early as March. The project is designed to monitor the tissue for changes in heart muscle cells’ mitochondria (their power supply) and ability to contract in low-gravity conditions.
Johns Hopkins Community Physicians (JHCP) announced today that it will open a third Howard County, Maryland, primary care office in mid-March 2023. The new site — Columbia North— is located at 8820 Columbia 100 Parkway, Suite 400, Columbia, Maryland 21045.
Endometriosis is a chronic condition affecting up to 10% of women between the ages of 15 and 44 in the United States, according to the U.S. Department of Health and Human Services. The uterus is lined with tissue — the endometrium — which is replenished every menstrual cycle to prepare for a fertilized egg. In people who have endometriosis, this tissue grows outside the uterus, and is commonly found on or around the reproductive organs including the fallopian tubes, ovaries, bladder and cervix.
Johns Hopkins Medicine researchers are collaborating with NASA to send human heart “tissue-on-a-chip” specimens into space as early as March. The project is designed to monitor the tissue for changes in heart muscle cells’ mitochondria (their power supply) and ability to contract in low-gravity conditions.
Researchers from Johns Hopkins Medicine and The Johns Hopkins University have created and preliminarily tested what they believe may be one of the first models for predicting who has the highest probability of being resistant to COVID-19 in spite of exposure to SARS-CoV-2, the virus that causes it.
Researchers at the Johns Hopkins Kimmel Cancer Center completed what is believed to be the first phase I trial of intravenous Helixor M in the U.S. aimed at determining dosing for subsequent clinical trials and to evaluate safety.
Eating disorders are behavioral conditions in which normal eating habits become disrupted and rewarded in an unhealthy way. They can affect a person’s physical and mental health, and often happen in combination with other psychiatric conditions such as depression, anxiety or substance use disorder.
In a bid to understand why mosquitoes may be more attracted to one human than another, Johns Hopkins Medicine researchers say they have mapped specialized receptors on the insects’ nerve cells that are able to fine-tune their ability to detect particularly “welcoming” odors in human skin.
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