The highest-ever resolution imaging of an infectious prion provides the first atomic-level data of how these abnormal proteins are assembled to cause fatal neurodegenerative diseases in people and animals—and how they can be potentially targeted by new therapies.
Computer and data science researchers at Case Western Reserve University are developing an Artificial Intelligence (AI)-powered tool to public health and other officials make more informed decisions when faced with infectious disease outbreaks. The National Science Foundation (NSF) recently awarded a $1.2 million grant to support the project, led by Yanfang (Fanny) Ye, the Theodore L. and Dana J. Schroeder Associate Professor of computer and data sciences at Case Western Reserve’s Case School of Engineering.
Researchers at the Case Western Reserve University School of Medicine, with colleagues from multiple research centers, will study the genomics of Alzheimer’s disease (AD) in people with African heritage throughout the United States.
Scientists at Case Western Reserve University have used Artificial Intelligence (AI) to identify new biomarkers for breast cancer that can predict whether the cancer will return after treatment—and which can be identified from routinely acquired tissue biopsy samples of early-stage breast cancer.
Vipin Chaudhary, chair of computer and data sciences at Case Western Reserve, is co-primary investigator on the new grant announced today by the U.S. National Science Foundation (NSF). He will collaborate with Ohio State computer science and engineering professor Dhabaleshwar Panda, the primary investigator on the project, which will focus on building AI systems for agricultural and wildlife management systems.
Researchers from Case Western Reserve University are hoping a new study could lead to a medical breakthrough in understanding certain types of oral cancer.
Case Western Reserve University researchers have demonstrated that the risk for myocarditis/pericarditis (heart inflammation) among male teens (12-17) diagnosed with COVID-19 is nearly 6 times higher than their combined risk following first and second doses of an mRNA COVID-19 vaccination. The risk for myocarditis/pericarditis among girls (ages 12-17) is 21 times greater from COVID-19 than from vaccines.
Case Western Reserve University launches new program meet the increasing demand by health care-related businesses and government agencies for experts in state, federal and international laws and regulations
A Case Western Reserve University researcher is leading an interdisciplinary global team that will use state-of-the-art technology to tackle an ancient question: How did ecological factors affect the evolution of our ancestors millions of years ago? The possible answers so intrigued the W. M. Keck Foundation that it awarded Armington Professor Beverly Saylor and her colleagues a $1.2 million grant to explore them.
Case Western Reserve University researchers studying prions—misfolded proteins that cause lethal incurable diseases—have identified for the first time surface features of human prions responsible for their replication in the brain.
The discovery of the Lowland Cichlid (Herichthys carpintis) spells bad news for natural-resource managers and conservationists already contending with the Rio Grande Cichlid, especially in Louisiana.
In a new study, supported by a five-year, $6.4 million grant from the National Eye Institute of the National Institutes of Health, researchers from Case Western Reserve University, University Hospitals and the Jaeb Center for Health Research, aim to finally determine which diabetic individuals can successfully donate their corneas for keratoplasty (and which should not).
Researchers from Case Western Reserve University have identified a potential new approach to better controlling epileptic seizures. Lin Mei, professor and chair of the Department of Neurosciences at the Case Western Reserve School of Medicine, who led the new study in mouse models, said the team found a new chemical reaction that could help control epileptic seizures.
For AI to continue to transform cancer diagnoses, researchers will have to prove that the success of their machine-learning tools can be reproduced from site to site and among different patient populations. Biomedical engineering researchers at Case Western Reserve University say they doing just that. They say they have demonstrated that their novel algorithms for distinguishing between benign and malignant lung cancer nodules on CT scan images from one site can now be successfully reproduced with patients from other sites and locations.
A team of researchers from the Jack, Joseph and Morton Mandel School of Applied Social Sciences interviewed 174 families to examine the use of health, medical and social services for youth with autism
Using ultra-high field magnetic resonance imaging (MRI) to map the brains of people with Down syndrome (DS), researchers from Case Western Reserve University, Cleveland Clinic, University Hospitals and other institutions detected subtle differences in the structure and function of the hippocampus—a region of the brain tied to memory and learning.
Medical researchers from Case Western Reserve University, New York University (NYU), and University Hospitals have been awarded a five-year, $3 million National Cancer Institute grant to develop and apply artificial intelligence (AI) tools for predicting which lung cancer patients will respond to immunotherapy.
The Mt. Sinai Health Care Foundation—continuing Mt. Sinai Medical Center’s century-old tradition of caring for Northeast Ohio—has expanded its commitment to the region through a $1 million challenge grant to the Case Western Reserve University School of Medicine. With this grant, the Mt. Sinai Health Care Foundation has provided over $31 million in lifetime support for Case Western Reserve.
Rodeo Therapeutics Corp., a drug-development startup founded by two leading researchers from the Case Western Reserve University School of Medicine and a third scientific partner, has been sold to Amgen Inc., a publicly traded international biopharmaceutical company. Under terms of the agreement, Amgen, based in Thousand Oaks, California, will acquire all outstanding shares of Rodeo for $55 million, plus “future contingent milestone payments potentially worth up to an additional $666 million in cash,” the companies announced today. Total consideration to Rodeo stakeholders could potentially be worth up to $721 million in cash.
Robert Herbold, who earned his MS in mathematics in 1966 and PhD in computer science in 1968 at Case Western Reserve University, has committed $2 million to endow an engineering professorship to recognize and support a faculty member who excels at teaching, builds new curricula and actively mentors students.
A new technique for sampling and testing cells from Barrett’s esophagus (BE) patients could result in earlier and easier identification of patients whose disease has progressed toward cancer or whose disease is at high risk of progressing toward cancer.
Scientists at the Case Western Reserve University School of Medicine have determined the structure of protein “fibrils” linked to Lou Gehrig’s disease and other neurodegenerative disorders—findings that provide clues to how toxic proteins clump and spread between nerve cells in the brain.
An international team of bioethicists and scientists, led by a researcher at Case Western Reserve University, contends it may be justified to go beyond the standing 14-day limit that restricts how long researchers can study human embryos in a dish. Going beyond this policy limit could lead to potential health and fertility benefits, and the authors provide a process for doing so.
African American men in Cuyahoga County have a 60% increased risk of being diagnosed with prostate cancer and an 80% increased risk of dying from prostate cancer compared to white men, according to data from the Case Comprehensive Cancer Center. With a new $2.75 million, three-year grant from the Bristol Myers Squibb Foundation, researchers at the Case Comprehensive Cancer Center at Case Western Reserve University will collaborate with a team of community partners in a different approach to fight this health disparity.
Of the 264 police officers who died in the line of duty in 2020 across the United States, more than half died of COVID-19, according to new data.
The weight of isolation and loss of social connection caused by the COVID-19 pandemic has compounded existing psychosocial-emotional issues already experienced by adults who identify as sexual or gender minorities (SGM). And while many people globally and across the United States—regardless of their gender identity—are experiencing pandemic anxiety at some level, those who identify as SGM appear to have been disproportionally affected by the pandemic both physically and mentally.
A new study by an international team of researchers found that adults with Down syndrome are more likely to die from COVID-19 than the general population, supporting the need to prioritize vaccinating people with the genetic disorder.
Located in the Sheila and Eric Samson Pavilion at the Health Education Campus of Case Western Reserve University and Cleveland Clinic, the Marian K. Shaughnessy Nurse Leadership Academy will offer a collaborative, welcoming and high-tech space for students and faculty to deepen their learning and research.
The National Institutes of Health (NIH) has awarded a $2.1 million, four-year research grant to Anirban Sen Gupta at Case Western Reserve University in Cleveland, Ohio, and collaborators at the University of Michigan and University of North Carolina, to advance the design of artificial platelets that can promote and stabilize clots to stop bleeding.
A team of researchers from the Case Western Reserve University School of Medicine, Case School of Engineering and Louis Stokes Cleveland VA Medical Center is developing a blood-test device as an early warning system to help prevent pressure injuries.
In a new study, Case Western Reserve University researchers identified some of the primary gaps in the connective tissue of the criminal justice system—among them failures to test rape kit DNA samples to unjustified doubts of victims’ statements.
Case Western Reserve University chemical engineer and researcher Rohan Akolkar has been elected as a Senior Member of The National Academy of Inventors (NAI).
A team of Case Western Reserve University researchers has found a way to measure key characteristics of proteins that bind to RNA in cells—a discovery that could improve our understanding of how gene function is disturbed in cancer, neurodegenerative disorders or infections.
A study led by Case Western Reserve University researchers found that patients with dementia were at a significantly increased risk for COVID-19—and the risk was higher still for African Americans with dementia.
Case Western Reserve University researchers who developed a portable sensor to assess the clotting ability of a person’s blood are working with the U.S. Navy to develop a rugged version of the device to detect problems with blood coagulation in cases of traumatic injury and preserve critical blood supplies.
Case Western Reserve University computer scientists and energy technology experts are teaming up to leverage the diagnostic power of artificial intelligence (AI) to make solar-power plants more efficient.
Case Western Reserve University’s HoloAnatomy® Software Suite will star this week in online events that Microsoft is hosting for colleges and universities-- Tuesday, Jan. 26, in a webinar titled “A New Vision for Medical Education” and Wednesday, Jan. 27, in Microsoft’s HoloLens Industry Summit, which will include an education break-out session.
Dustin Tyler, Founder of Human Fusions Institute at Case Western Reserve University in Cleveland, Ohio, and Shelly Palmer, CEO of The Palmer Group, discuss Human Fusions Institute, NeuroReality™, and the future of human-tech relationships in a virtual meeting.
Researchers at the Center for Computational Imaging and Personalized Diagnostics (CCIPD) at Case Western Reserve University have preliminarily validated an artificial intelligence (AI) tool to predict how likely the disease is to recur following surgical treatment for prostate cancer.
For the eighth straight year, Case Western Reserve students, faculty and alumni will showcase an array of science, engineering and technology innovation including "augmented reality and telepresence," 3D printed violins for children, COVID-19 apps and a neuro fitness tool.
Researchers at Case Western Reserve University find that focusing on diversion—instead of detention—yields positive results for youth with behavioral health issues
Child care programs can be safe within the context of low community transmission of COVID-19, according to new research from Case Western Reserve University, based on data from child care programs throughout Ohio. The study took place from Aug. 15 to Nov. 20, during a timeframe of relatively low community transmission of COVID-19. The team found COVID-19 infection rates at child care programs have been low.
The Center for Computational Imaging and Personalized Diagnostics (CCIPD) at Case Western Reserve University and Boehringer Ingelheim, one of the world’s largest pharmaceutical companies will leverage the power of CCIPD’s image computing AI solutions to identify patterns and links between cellular response and underlying molecular drivers, with the goal of advancing therapeutics for diseases with no satisfactory treatment option.
Cancer patients, especially newly diagnosed and African American patients, are significantly at risk for COVID-19 infection, hospitalization and mortality, according to a new study published in JAMA Oncology by researchers from Case Western Reserve University School of Medicine and the Case Comprehensive Cancer Center.
The Human Trafficking Clinic at Case Western Reserve University works directly with trafficking survivors and populations that face a high-risk of trafficking victimization.
A novel Alzheimer’s disease marker—coming early in progression of the condition—could open significant new fronts of research into possible therapies
Researchers surveyed 105 agencies to better understand service, policy and research needs—and get feedback about potential strategies to protect children from intimate partner violence.
A team of researchers at the Case Western Reserve University School of Medicine has taken a major step toward understanding the mechanisms involved in the formation of large clumps of tau protein, a hallmark of Alzheimer’s disease and several other neurodegenerative disorders.
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