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Researchers from St. Jude Children’s Research Hospital will present their work at the 61st annual meeting of the American Society of Hematology.

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The Guardian of Excellence Award recognizes top-performing health care organizations that have achieved the 95th percentile or above of performance in Patient Experience in Pediatrics.

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Eighteen scientists from St. Jude Children’s Research Hospital were recently named Highly Cited Researchers for 2019 by the Web of Science Group.

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Research co-led by a St. Jude investigator and researchers from Columbia University and the New York State Psychiatric Institute reveals the mechanics of how some transporter proteins function with stunning specificity.

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An international collaboration has identified therapy-induced, drug-resistance mutations in children with acute lymphoblastic leukemia who relapse

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A St. Jude Children’s Research Hospital study lowered the rate of relapse for patients with acute lymphoblastic leukemia.

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Immunologists at St. Jude Children’s Research Hospital have discovered key biological switches that control regulatory T cells—specialized white blood cells that keep the immune system in check.

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The International Atomic Energy Agency (IAEA) and St. Jude Children’s Research Hospital are joining forces to combat childhood cancers in developing countries.

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Lindsay Schwarz, Ph.D, an assistant member in the Developmental Neurobiology Department at St. Jude Children’s Research Hospital, has won a prestigious early career award from the National Institutes of Health. The High-Risk, High-Reward Research program supports exceptionally creative scientists pursuing research that has potential for broad impact in biomedical, behavioral or social sciences.

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This week, staff at St. Jude Children's Research Hospital welcomed their two newest colleagues, Huckleberry, a Golden Doodle, and Puggle, a Golden Retriever. They are the first hires in the newly launched St. Jude Paws at Play facility dog program.

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St. Jude Children’s Research Hospital scientists have identified a molecule that plays a pivotal role in determining the fate of cells under stress, much like a Roman emperor deciding the fate of gladiators in the coliseum.

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St. Jude Children’s Research Hospital has acquired the first Ascend 1.1 GHz Nuclear Magnetic Resonance Spectrometer, the largest and most powerful device of its kind from Massachusetts-based Bruker Corp.

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St. Jude Children’s Research Hospital scientists have taken whole genome sequencing to the next level by creating a 3D map of the genome to better understand development and disease

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A report from St. Jude Children’s Research Hospital links inherited mutations in the BRCA2 gene with an increased risk of developing non-Hodgkin lymphoma in children and adolescents. The work appears as an advance online publication today in JAMA Oncology.

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Investigators at St. Jude Children’s Research Hospital and Massachusetts General Hospital, alongside others, have revealed the cells of origin for specific subtypes of medulloblastoma, the most common malignant pediatric brain tumor. The work also has implications for how medulloblastoma is classified, which may eventually shape clinical care. The work appears as an advance online publication today in Nature.

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St. Jude investigators have discovered an association between a deficiency in the enzyme neuraminidase 1 and the build-up of connective tissue in organs such as the muscle, kidney, liver, heart and lungs.

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St. Jude Children’s Research Hospital scientists have discovered a pathway that functions like a car wash to prevent the buildup of a toxic protein associated with Alzheimer’s disease. The report appeared online today in the journal Cell.

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An international research team has discovered a gene that triggers a process called “exhaustion” in the immune T cells used to battle cancer in immunotherapy. The gene, called Tox, launches a process that remodels the cells’ machinery to weaken their ability to attack cancer cells, as well as infections. The discovery, published in advance online in the journal Nature, could lead to diagnostic tests to detect T cell exhaustion, and the researchers hope their basic findings will also result in techniques to prevent exhaustion.

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Martine Roussel, Ph.D., a member of the Department of Tumor Cell Biology and co-leader of the Cancer Biology Program at St. Jude Children’s Research Hospital, was elected to the National Academy of Sciences. Roussel is one of 100 new members and 25 foreign associates recognized this year by the renowned society of scholars for their distinguished and continuing achievements in original research.

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The American Association for Cancer Research has named Esther Obeng, M.D., Ph.D., of St. Jude Children’s Research Hospital recipient of the 2019 Gertrude B. Elion Cancer Research Award.

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Dr. Mullighan will help guide precision medicine, preclinical and other strategic research initiatives within the cancer center

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Research at St. Jude Children’s Research Hospital has identified a genomic risk factor associated with stroke in childhood cancer survivors. The findings were announced today at a press conference as part of the American Association for Cancer Research annual meeting in Atlanta. This investigation draws on whole genome sequencing and other data gathered longitudinally through the St. Jude Lifetime Cohort (SJLIFE) study.

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Acute erythroid leukemia (AEL) is a high-risk cancer with a dismal prognosis, uncertain genetic basis and controversy surrounding the diagnosis. That is changing, thanks to research led by St. Jude Children’s Research Hospital that appears today in the journal Nature Genetics. The researchers completed the largest, most comprehensive genomic analysis yet of AEL and identified six age-related subgroups with distinct mutations and patterns of gene expression as well as treatment outcomes.

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The American Association for Cancer Research (AACR) has announced that the 13th annual AACR Team Science Award will be presented to the Cancer Control and Survivorship Program at St. Jude Children’s Research Hospital. The Cancer Control and Survivorship Program is a multidisciplinary research program of the St. Jude Comprehensive Cancer Center, which strives to improve the quality of life of individuals surviving childhood cancer. Leslie L. Robison, PhD, chair of the Department of Epidemiology & Cancer Control, and Melissa Hudson, MD, director of the Division of Cancer Survivorship, lead the program.

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St. Jude Children’s Research Hospital scientists have completed one of the largest studies yet designed to advance understanding of why Hispanic children are more likely to develop leukemia and less likely to survive

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For the ninth consecutive year, Fortune magazine named St. Jude Children’s Research Hospital to the “100 Best Companies to Work For” list.

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St. Jude Children’s Research Hospital has been named a recipient of Microsoft Corp.’s 2019 Health Innovation Award for the St. Jude Cloud, a data-sharing resource for the global research community that gives scientists immediate access to genomics data that previously could take weeks to download.

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St. Jude Children’s Research Hospital researchers used a comprehensive method to reduce drug interaction alerts, improving electronic health record systems to lower alert fatigue and increase patient safety.

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The program, known as the Master of Science in global child health, will take two years to complete, and is offered as a blended program with a competency-based curriculum.

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Study led by St. Jude Children’s Research Hospital found treatment guided by measuring minimal residual disease was associated with better outcomes for hypodiploid acute lymphoblastic leukemia patients

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More than 90 percent of B-ALL cases can now be classified by subtype, up from 70 percent several years ago. The number of proposed B-ALL subtypes is now 23.

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The 60th Annual Meeting of the American Society of Hematology will feature research from St. Jude Children’s Research Hospital on topics ranging from the genomic basis and vulnerabilities of leukemia to an update on gene therapy for hemophilia B to advances in sickle cell disease and beta-thalassemia.

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The Public Resource of Patient-derived and Expanded Leukemias (PROPEL) offers patient-derived xenograft samples free of charge for researchers worldwide.

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St. Jude Children’s Research Hospital scientists found that the combined effect of common genetic variations can dramatically increase risk of breast cancer for female pediatric cancer survivors

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Children with acute lymphoblastic leukemia (ALL) gain weight during treatment, and researchers at St. Jude Children’s Research Hospital have discovered that this problem starts during remission-induction treatment and suggests that early intervention should be considered. Chemotherapy drugs to treat ALL contribute to an increased risk of becoming overweight or obese. The scientists’ findings show that obesity was prevalent - and height growth, especially in patients with identified risk factors - was compromised.

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Read how a discovery in bacteria in the 1980s led to a promising new class of compounds for treatment of PKAN, a progressive neurodegenerative disease.

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Shengdar Tsai, Ph.D., an assistant member of the Department of Hematology at St. Jude Children’s Research Hospital, has received a five-year $3 million grant from the National Institutes of Health’s Common Fund for his work on genome editing safety.

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St. Jude Children’s Research Hospital today announced a five-year collaboration with World Health Organization aimed at transforming cancer care worldwide to cure at least 60 percent of children with six of the most common types of cancer by 2030.

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St. Jude Children’s Research Hospital scientists have identified another way the process that causes oil to form droplets in water may contribute to solid tumors, such as prostate and breast cancer. The findings appear today in the journal Molecular Cell. Researchers found evidence that mutations in the tumor suppressor gene SPOP contribute to cancer by disrupting a process called liquid-liquid phase separation. Liquid-liquid phase separation is seen often in nature and is the reason why oil and vinegar separate in salad dressing.

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The research will not only aid basic understanding of brain development, but also provide a foundation for understanding the cellular origins of brain disorders caused by errors in development. These anatomical defects include Joubert syndrome, Dandy-Walker malformation and pontocerebellar hypoplasia. The database will enable future studies tracing the cellular origins of childhood brain tumors such as medulloblastoma, astrocytoma and ependymoma. Researchers worldwide can interact with the data via an interface St. Jude has created called Cell Seek.

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St. Jude Children’s Research Hospital investigators have unraveled the origins and identified mutations associated with a perplexing form of acute leukemia. The landmark study appears today as an advance online publication in the journal Nature and lays the foundation for more effective treatment of patients with the high-risk cancer. The research focused on mixed phenotype acute leukemia (MPAL), a subtype of acute leukemia that accounts for about 3 percent of the estimated 3,500 pediatric cases of acute leukemia diagnosed annually in the U.S. Their treatment is complicated because MPAL does not fit cleanly into a single diagnosis, but includes features of both acute lymphoblastic leukemia and acute myeloid leukemia.

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The immune system appears to put a premium on maintaining lung function in infants infected with the influenza virus by mounting a rapid response to repair damaged cells, according to research led by St. Jude Children’s Research Hospital.

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Research from the St. Jude Children’s Research Hospital—Washington University Pediatric Cancer Genome Project has revealed new vulnerabilities and leads for treatment of rhabdomyosarcoma

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For the second time in a row, the National Cancer Institute has awarded St. Jude Children’s Research Hospital the highest possible rank of “exceptional” and the best numerical score in the hospital’s history during the renewal of the hospital’s $36 million Comprehensive Cancer Center grant. St. Jude is the first and only NCI-designated Comprehensive Cancer Center that is devoted solely to children.

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Valerie Crabtree, Ph.D., a St. Jude psychologist and leading expert in research on sleep disruptions in children with cancer, has been promoted to Chief of Psychosocial Services.

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In the first study of its kind, St. Jude Children’s Research Hospital investigators have found that more than half of pediatric central nervous system tumor survivors do not achieve complete independence as adults. Researchers looked at six aspects of independence in more than 300 survivors, including employment, independent living, marital status, assistance with routine or personal care needs, and the ability to drive.

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Adult survivors of childhood cancer should be screened for financial problems that might cause them to delay or skip medical care or to suffer psychological distress. The recommendation from St. Jude Children’s Research Hospital researchers followed an analysis that found 65 percent of survivors reported financial challenges related to their childhood cancer diagnoses. More than half of survivors (51.1 percent) indicated they worried about paying for care, and 33 percent said finances kept them from seeking medical care.

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St. Jude Children’s Research Hospital scientists report the protein complex mTORC1 serves as a bridge between environmental signals and metabolic programs to influence the fate of developing T cells

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A research team led by a St. Jude Children’s Research Hospital epidemiologist has conducted the largest analysis to date of how adult survivors of childhood cancer view their health risk. The scientists found that a surprisingly high number of survivors showed a lack of concern for their future well-being. The analysis of questionnaire data from 15,620 survivors found that 31 percent said they were not concerned about their future health and 40 percent were unconcerned about developing new cancers.