Improper functioning of the mitochondria may help account for the fact that african-american men with prostate cancer respond poorly to conventional chemotherapy
Chronic heavy alcohol consumption may lead to an increase in the rate of nicotine metabolism, which could be a contributing factor to poor smoking cessation rates in smokers addicted to alcohol.
Roswell Park Cancer Institute (RPCI) researchers are investigating agents that target and disrupt the trafficking of monoclonal antibodies in multiple myeloma, a cancer of the bone marrow. The results will be presented at the American Association for Cancer Research (AACR) Annual Meeting 2016, to be held April 16-20 in New Orleans.
New research from Roswell Park Cancer Institute (RPCI) shows that promising cancer drugs used in combination can have significant therapeutic impact on a particularly aggressive subtype of diffuse large B-cell lymphoma (DH-DLBCL) in preclinical studies. The researchers will present their findings at the American Association for Cancer Research (AACR) Annual Meeting 2016, to be held April 16-20 in New Orleans.
Researchers at Roswell Park Cancer Institute (RPCI), in collaboration with investigators from the cooperative group SWOG, have found that use of multivitamins prior to diagnosis may reduce the risk of neuropathy in breast cancer patients treated with the class of drugs known as taxanes. The team will present their findings at the American Association for Cancer Research (AACR) Annual Meeting 2016, to be held April 16-20 in New Orleans.
Roswell Park Cancer Institute (RPCI) research on the most potent form of vitamin D, commonly called calcitriol, offers new insights into approaches that may enhance the antitumor activity of this much-studied human hormone. The researchers will share their findings in an oral presentation at the American Association for Cancer Research (AACR) Annual Meeting 2016, to be held April 16-20 in New Orleans.
Two previously unrecognized genetic markers may predict whether breast cancer patients would benefit from chemotherapy followed by tamoxifen, according to preclinical research from Roswell Park Cancer Institute (RPCI), in collaboration with the cooperative research group SWOG and St. Jude Children’s Research Hospital. The results of this research will be presented at the American Association for Cancer Research (AACR) Annual Meeting 2016, to be held April 16-20 in New Orleans.
Researchers report that support from the sponsoring academic institution and clear role expectations are critical for the success of programs that employ lay health advisors
Post-menopausal women who use metformin long-term for the treatment of diabetes may be at lower risk for developing certain cancers and dying from these diseases, reports a large prospective study from researchers at Roswell Park Cancer Institute (RPCI) and the University at Buffalo (UB). Their analysis was based on data from the Women’s Health Initiative (WHI), a series of large studies undertaken to address common health issues in women. The researchers also found that women with diabetes, compared to women without the disease, were more likely to develop cancer. The team’s findings were published in the International Journal of Cancer.
Roswell Park Cancer Institute has become the first American cancer center and only the second institution in the U.S. to implement Elekta’s Leksell Gamma Knife Icon radiosurgery system, which expands the range of conditions that can be treated through radiosurgery.
The Population Assessment of Tobacco and Health (PATH) Study, a longstanding effort to document and interpret tobacco use in the U.S., has been awarded another nine years of funding from the National Institutes of Health (NIH) and U.S. Food and Drug Administration (FDA). The study will be conducted by Westat of Rockville, Md., with Roswell Park Cancer Institute (RPCI) continuing as scientific lead and Andrew Hyland, PhD, Chair of the RPCI Department of Health Behavior, serving as principal investigator. Funding to Roswell Park over the term of the contract is expected to total $17.7 million.
Ovarian cancer is a constellation of different cancers that may originate in other organs and should not be treated as a single disease, concludes a new congressionally mandated report from the Institute of Medicine (IOM) of the National Academies of Sciences, Engineering, and Medicine.
In the first study of intravital microscopy in humans, Roswell Park scientists report that this approach for visualizing tumor blood vessels in real time during surgery is not only feasible, but that it revealed unexpected findings about the vasculature of human tumors.
Dr. Marc Ernstoff will head the Division of Hematology/Oncology in the Department of Medicine in the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo and the Department of Medicine at Roswell Park Cancer Institute (RPCI), where he will also serve as and senior vice president of clinical investigation.
Successful recruitment and retention efforts, new collaborations with regional partners and groundwork for new clinical and scientific initiatives have all marked Candace S. Johnson's first year as President and CEO of Roswell Park Cancer Institute.
An analysis of 145 different electronic-cigarette flavoring products reveals that many e-cigarette users may be exposed to a potentially harmful chemical, benzaldehyde. The highest concentrations were detected in vapor from cherry-flavored products.
BUFFALO, N.Y. — Roswell Park Cancer Institute (RPCI) has joined with all the top cancer centers across the nation in issuing a statement urging for increased HPV vaccination for the prevention of cancer. Recognizing that insufficient vaccination is a public health threat, these leading institutions have called upon the nation’s physicians, parents and young adults to take advantage of this rare opportunity to prevent many types of cancer.
A research team from the Department of Pharmacology and Therapeutics at Roswell Park Cancer Institute (RPCI) has discovered a new class of small-molecule compounds that are good candidates for development of novel targeted therapies in the treatment of leukemia and lymphoma. This new class of compounds drives cancer cells to suicide, the researchers report in the peer-reviewed journal Cell Death and Disease.
Researchers from Roswell Park Cancer Institute have reported findings about a new synthetic form of camptothecin that appears to have greater potency, longer efficacy and fewer adverse side effects than irinotecan and topotecan.
Scientists at Roswell Park Cancer Institute and Inria demonstrate that mathematical models can provide useful clues about the impact of surgery on metastasis, and may help to predict the risk of cancer spread.
Researchers have identified 10 genes whose inhibition appears to protect kidney cells. The findings point the way to strategies for preventing acute kidney injury and may also help to evade drug resistance in cancer therapy.
Scientists from the Children’s Cancer Institute–Australia, Roswell Park Cancer Institute and Incuron LLC have identified a new treatment approach for a highly aggressive and usually fatal subtype of neuroblastoma.
Kara Kelly, MD has been appointed as the new leader of the joint program in pediatric hematology/oncology at Women & Children’s Hospital of Buffalo, Roswell Park Cancer Institute, UBMD Pediatrics and the University at Buffalo
Writing in Scientific Reports, researchers led by a group from Roswell Park Cancer Institute have shared new insights about a subset of T cells that appear to both inhibit cancer growth and enhance the tumor-killing powers of other immune cells.
Three-quarters of women treated for ovarian cancer face relapse of their disease. And while those who respond well to initial therapy do tend to survive longer, they require additional treatment for recurring cancer just as frequently as other women whose initial treatment response was not so pronounced. This is a key conclusion of new research from Roswell Park Cancer Institute (RPCI), published online ahead of print in the journal Gynecologic Oncology, that contributes new information about the dynamics of recurrent ovarian cancer.
Significant differences in attitudes toward smoking cessation are reported between two generations of smokers in Northern Appalachia in new research from Roswell Park Cancer Institute (RPCI). The qualitative study about beliefs, attitudes and experiences of current and former smokers in Northern Appalachian communities, published online ahead of print in the Journal of Community Health, contributes novel information about smoking cessation.
A new clinical trial at Roswell Park Cancer Institute and the Cleveland Clinic will assess the effectiveness of the SurVaxM vaccine in combination with standard chemotherapy as treatment for glioblastoma, a rare but often-fatal cancer of the brain.
A history of oral contraceptive use and having at least one child increased longevity by nearly three years in patients diagnosed with ovarian cancer, according to a Roswell Park Cancer Institute (RPCI) study recently published online ahead of print in the International Journal of Gynecological Cancer.
Roswell Park Cancer Institute (RPCI) researchers, together with input from African-American community leaders in Buffalo, have created an outreach effort that provides racial/ethnic minority and medically underserved communities with educational programs regarding the public’s participation in biomedical research. The program is the basis of a recent study published by a team of local collaborators.
It has long been known that rates of breast and cervical cancer screening among Latinas are low compared to rates for U.S. women overall. A study led by researchers at Roswell Park Cancer Institute (RPCI) found that age and fear of cancer diagnosis are among the reasons why Latina women do not continue participation following breast and cervical cancer education programs. The research was published in the Journal of Health Communication: International Perspectives.
Tobacco cessation provided significant survival benefit for lung cancer patients who quit smoking shortly before or after diagnosis, despite the severity of the disease. Results of the Roswell Park Cancer Institute study were published in the Journal of Thoracic Oncology.
Roswell Park Cancer Institute will provide clinical consultations and training for staff at Lakeshore Cancer Center, Lagos, Nigeria, through an affiliation announced today.
Early age at menarche, or first menstrual cycle, could play a role in the disproportionate incidence of estrogen receptor (ER)-negative breast cancers diagnosed among African-American women, according to a study published in the Journal of the National Cancer Institute.
Roswell Park will receive a five-year, $10 million NCI award to continue its PDT research program in head and neck cancers and conduct clinical trials in collaboration with other centers.
OmniSeq, LLC has officially begun its spin-out from Roswell Park Cancer Institute and will immediately begin commercializing its suite of innovative products that match cancer patients to therapies tailored specifically to them.
Blood and Marrow Transplantation (BMT) is a potentially curative treatment for patients with leukemia or other life-threating blood diseases. With a goal of increasing survival rates, a research team led by Roswell Park Cancer Institute (RPCI) investigators verified patient outcome data submitted by more than 150 U.S. transplant centers over an 11-year period to the Center for International Blood and Marrow Transplant Research (CIBMTR). The detailed investigation — published in the journal Biology of Blood and Marrow Transplantation — offers insight into different causes of death. The results of this genome-wide association study led to the development of a first-of-its-kind definition of specific causes of mortality after unrelated-donor, or allogeneic, BMT.
A large cooperative-group study has confirmed previous evidence that lenalidomide delays time to disease progression for patients with multiple myeloma and is an important treatment option for patients with the disease.
A multiplatform biomarker analysis of squamous cell anal carcinoma samples led by Roswell Park in conjunction with Caris Life Sciences has revealed several actionable targets.
A collaborative team of researchers led by Alex A. Adjei, MD, PhD, FACP, of Roswell Park Cancer Institute (RPCI) will share results from the first clinical study of the anticancer effects of the novel agent entolimod at the American Society of Clinical Oncology (ASCO) 51st Annual Meeting in Chicago. Their findings confirm preclinical evidence that the agent, which is derived from salmonella flagellin, is worthy of further investigation as treatment for some of the most common and most resilient solid-tumor cancers.
The incidence of melanoma, a deadly form of skin cancer, has increased by more than 250% among children, adolescents and young adults since 1973, according to award-winning research to be presented by Roswell Park Cancer Institute (RPCI) at the American Society of Clinical Oncology (ASCO) 51st Annual Meeting in Chicago.
Roswell Park Cancer Institute (RPCI) researchers have developed an accurate, individualized post-operative survival calculator and integrated the technology into a mobile application compatible with smartphone technology for oncologists and patients diagnosed with colon cancer. Information about the calculator will be presented at the American Society of Clinical Oncology (ASCO) 51st Annual Meeting in Chicago.
Research found no racial or ethnic disparities among patients who participate in the Blood and Marrow Transplantation (BMT) Program at Roswell Park Cancer Institute (RPCI). The results were published in a recent issue of the journal Biology of Blood and Marrow Transplantation.
In findings reported in Cell Death and Differentiation, the researchers demonstrate that the enzyme GMPS drives melanoma growth, and propose a new strategy for targeting that protein.
Long-term and frequent use of aspirin is associated with significantly decreased risk of cervical cancer, according to a study led by researchers at Roswell Park Cancer Institute (RPCI) and published in the Journal of Lower Genital Tract Disease.
The latest research from the team that discovered the novel anticancer agent FL118 highlights its distinctive characteristics and provides insights into its ability to overcome treatment resistance.
Roswell Park Cancer Institute’s 15th and first female president, Dr. Candace Johnson, has begun her tenure by reorganizing the talent around her. The comprehensive center has announced a slate of strategic new appointments and faculty/staff promotions.
Following a national search, Candace S. Johnson, PhD, has been named President & CEO of Roswell Park Cancer Institute
In a large study using data from the Women's Circle of Health Study, epidemiologists have determined that gene variations associated with breast cancer risk diverged significantly between African-American and women of European descent.
Researchers at Roswell Park have discovered two promising biomarker candidates in prostate cancer. Their work may lead to a new treatment strategy aggressive, treatment-resistant forms of the disease.
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