FDA approved an imaging drug known as Cytalux (pafolacianine), which is attracted to ovarian cancer tissue and illuminates it when exposed to fluorescent light, allowing surgeons to more easily find and more precisely remove the cancer.
About 12 percent of patients who receive implantable cardiac devices such as a pacemaker or defibrillator and fill an opioid prescription after surgery will consistently use the pain medication in the months afterward, raising the potential for addiction following these common procedures and identifying another pathway that could contribute to the national opioid crisis.
The Perelman School of Medicine at the University of Pennsylvania will continue to be on the leading edge of autoimmune research and care with the launch of the Colton Center for Autoimmunity at Penn. The new center unites research and patient care programs across Penn to drive advances in autoimmune diagnosis, prognosis, and treatment.
Two genetic risk variants that are carried by nearly 40 percent of Black individuals may exacerbate the severity of both sepsis and COVID-19, a team of researchers from the University of Pennsylvania’s Perelman School of Medicine have found.
Patients enrolled in COVID Watch, an algorithmically driven text messaging system backed by a small team of nurses, were 68 percent less likely to die from COVID-19
Consuming a low amount of caffeine during pregnancy could help to reduce gestational diabetes risk, according to researchers in the Perelman School of Medicine at the University of Pennsylvania.
Cancer patients who are ineligible for clinical trials receive immune checkpoint inhibitors (ICI) at greater rates than patients who are trial eligible despite no survival benefit, according to a new study by researchers at the Perelman School of Medicine at the University of Pennsylvania. The study, published in JAMA Oncology, suggests that the positive results for phase 3 clinical trial participants receiving ICI treatment may not translate to patients who are ineligible for trials due to factors such as organ dysfunction.
Florencia Greer Polite, MD, chief of the Division of General Obstetrics and Gynecology at the Perelman School of Medicine at the University of Pennsylvania, has been selected for the 2022 Carol Emmott Fellowship class by the Carol Emmott Foundation, a national nonprofit organization dedicated to achieving gender equity in healthcare leadership and governance.
The COVID-19 Triage Tool at Penn Medicine categorized almost every patient into a safe classification and took burdens off clinicians during the height of the pandemic
Two Penn Medicine faculty members, Kiran Musunuru, MD, PhD, and Daniel Rader, MD, are being honored with prestigious awards from the American Heart Association (AHA) for their achievements in cardiovascular research. Both awards will be presented during the Presidential Session on Sunday, Nov. 14, at the association’s Scientific Sessions 2021.
Dilated cardiomyopathy due to titin gene mutations involves both a shortage of good titin and a buildup of mutant, potentially “bad” titin
Penn Medicine has been awarded a $9.5 million grant from The Warren Alpert Foundation (WAF) to continue its efforts to increase diversity in genetic counseling, a field that, despite impressive leaps forward in genetic knowledge, lacks a diverse workforce.
Weight gain and high blood sugar caused by a damaged internal clock was corrected by researchers, who changed the length of the “day” in mice
PHILADELPHIA— New research shows that testosterone promotes melanoma proliferation by activating a newly recognized nonclassical testosterone receptor in melanoma cells called ZIP9 (encoded by the SLC39A9 gene), a zinc transporter that is not intentionally targeted by any available therapeutics but is widely expressed in human melanoma.
Penn Medicine's new Pavilion on the Hospital of the University of Pennsylvania's campus has broken new ground for sustainable healthcare construction and design with Leadership in Energy and Environmental Design (LEED) Healthcare Gold Certification.
New research has revealed that red blood cells function as critical immune sensors by binding cell-free DNA, called nucleic acid, present in the body’s circulation during sepsis and COVID-19, and that this DNA-binding capability triggers their removal from circulation, driving inflammation and anemia during severe illness and playing a much larger role in the immune system than previously thought. Scientists have long known that red blood cells, which are essential in delivering oxygen throughout the body, also interacted with the immune system, but didn’t know whether they directly altered inflammation, until now. The study, led by researchers at the Perelman School of Medicine at the University of Pennsylvania, was published today in Science Translational Medicine.
By collecting data from Yelp reviews on health care facilities and matching them to location data, Penn research shows how online reviews can provide a window into better care
Researchers find that restoring CDKL5 gene activity reverses many disease signs in young adult mice
FREE Breast Mammography for women in need over 40, being provided by Penn Medicine and Siemens Healthineers. NO INSURANCE REQUIRED. In North Philly in West Lehigh neighborhood, weekdays from Monday, Oct. 18 through Friday, Oct. 29, from 9 a.m. to 7 p.m.
In an unprecedented effort to address the harmful effects of structural racism on health, 60 predominantly Black neighborhoods in Philadelphia will be part of an ambitious study to assess the impact of a multi-component intervention addressing both environmental and economic injustice on health and well-being, led by Penn Medicine researchers Eugenia C. South, MD, MHSP and Atheendar Venkataramani, MD, PhD. This randomized controlled trial (RCT), is funded by a nearly $10 million dollar grant (1-U01OD033246-01) from the National Institutes of Health (NIH) Common Fund.
Challenging common beliefs, new research shows patterns of recovery to be similar for patients who received spinal anesthesia and those who got general anesthesia
In an effort to reduce disparities and increase the understanding of suicide, the National Institutes of Health awarded Penn Medicine researchers a grant of more than $14 million over the next five years to develop the Penn Innovation in Suicide Prevention Implementation Research (INSPIRE) Center.
This quarter, 22 projects will receive Penn Medicine CAREs funding. From leading local park cleanups to providing student-athlete support, employees across Penn Medicine volunteer their time and resources to strengthen the communities they serve, supported by the CAREs program.
Visitors and staff at Penn Medicine’s new Pavilion, opening this October, will have food and drink options that include national celebrity chef Tom Colicchio’s Root & Sprig and Philadelphia coffee guru Thane Wright’s Bower Cafe.
Exposure to neighborhood gun violence is associated with increased odds of mental health-related pediatric Emergency Department (ED) visits among children living within four to five blocks of a shooting, according to research by the Perelman School of Medicine at the University of Pennsylvania and Children’s Hospital of Philadelphia, published today in JAMA Pediatrics.
The National Institutes of Health (NIH) has selected Penn Medicine as one of 25 award recipients across 30 sites in the United States to serve as Impact of Genomic Variation on Function (IGVF) investigators, with the goal of better understanding how genetic differences impact how human genes function, and how these variations influence human health and disease.
New research shows that Multiple Sclerosis (MS) patients undergoing anti-CD20 (aCD20) treatment – which depletes the B cells that contribute to the MS attacks – are able to mount robust T-cell responses to the mRNA COVID-19 vaccines, despite having a muted antibody response to the vaccines.
PHILADELPHIA – It was a scientific discovery 16 years ago that paved the way for creation of lifesaving vaccines when the COVID-19 pandemic spread across the globe in 2020. Now, the two Penn Medicine researchers behind the findings are again being recognized for their innovative and monumental work, which has ushered in a new era of vaccine technology.
Representatives from Penn Medicine and the United States Navy will sign a unique agreement today marking the start of a three-year partnership to integrate members of the Navy with the Trauma Division at Penn Presbyterian Medical Center (PPMC). The program, known as the Naval Strategic Health Alliance for Readiness and Performance, is designed to provide sustained experiences in all aspects of trauma care – from surgery to anesthesiology to nursing – in one of the nation’s busiest trauma centers. The eleven Navy team members bring a wealth of experience with multiple deployments around the globe that will promote new approaches and knowledge across both civilian and military healthcare.
New study shows CAR T cells expressing RN7SL1 can activate the body’s natural immune cells against difficult-to-treat cancers
New research has uncovered a precision medicine test using blood proteins to identify a novel patient subgroup of idiopathic multicentric Castleman disease (iMCD), a rare blood disorder, who are more likely to respond to siltuximab, the only FDA approved treatment for the disease.
A Penn Medicine study showed that giving underserved patients at risk of heart disease a choice in their physical activity goal, then having them start right away, resulted in the most change
“Fund for Health” announced first round of funding for companies that aim to strengthen social determinants of health
PHILADELPHIA – For their landmark research that set a foundation for the mRNA SARS-CoV-2 vaccines, Drew Weissman, MD, PhD, the Roberts Family Professor of Vaccine Research, and Katalin Karikó;, PhD, an adjunct professor of Neurosurgery at the Perelman School of Medicine at the University of Pennsylvania and a senior vice president at BioNTech, have been selected to receive the 2021 Albany Prize.
The United States’ longest-running NIH-sponsored musculoskeletal research center will receive $4M to continue its studies of everything from ligament tears to osteoarthritis
PHILADELPHIA – The U.S. Food and Drug Administration (FDA) has given the first full approval to a COVID-19 mRNA vaccine, which uses modified mRNA technology invented and developed by scientists in the Perelman School of Medicine at the University of Pennsylvania, whose years of research in mRNA science laid a critical piece of the foundation for the largest global vaccination campaign in history.
In one of the most comprehensive genome-wide association studies of its kind, Penn researchers have identified 182 genes likely responsible for kidney function — many of which can be targeted with existing drugs — and 88 genes for hypertension.
Penn researchers have discovered that TSLP stimulates the immune system to release lipids through the skin’s oil-producing sebaceous glands in mice.
Messenger-RNA (mRNA) vaccines against the coronavirus that causes COVID-19 provoke a swift and strong response by the immune system’s T cells—the heavy armor of the immune system—according to a study from researchers in the Perelman School of Medicine at the University of Pennsylvania.
A new study from the Perelman School of Medicine at the University of Pennsylvania shows how to overcome resistance to CAR T cell therapy with an experimental small molecule inhibitor.
A new study shows that over a third of all members of Congress held health care-related assets with a median total value per member of over $43,000 between 2004 and 2014.
A meta-analysis of nearly 200,000 men revealed 22 new genetic locations that could be susceptible to inherited testicular germ cell tumors.
Penn Medicine hospitals have once again been ranked among the top in the nation by U.S News & World Report. The combined enterprise of the Hospital of the University of Pennsylvania and Penn Presbyterian Medical Center is ranked #13 in the nation on the magazine’s prestigious annual Honor Roll for the 15th consecutive year. HUP/PPMC is also ranked as the top hospital in Pennsylvania and #1 in the Philadelphia metro area.
To better coordinate health data projects across the health system and cement its status as a leader in informatics, Penn Medicine is launching a new hub center
Researchers have discovered a limitation of the immune system in battles against cancers or viruses: T cells remain programmed to stay exhausted even weeks after exposure to a virus ended. Scientists need to take this "T cell exhaustion” into account when devising immune-based therapies.
A new technology for cellular immunotherapy developed by Abramson Cancer Center researchers at Penn Medicine showed promising anti-tumor activity in the lab against hard-to-treat cancers driven by the once-considered “undruggable” KRAS mutation, including lung, colorectal, and pancreatic.
In Philadelphia, when a home received repairs through a city-funded program, total crime dropped by 21.9% on that block, and as the number of repaired houses on a block increased, instances of crime fell even further, according to research from the Perelman School of Medicine at the University of Pennsylvania published today in JAMA Network Open.
New research reveals that the same framework of proteins and peptides that can detect Alzheimer's disease in cerebrospinal fluid can also detect other forms of neurodegeneration, like frontotemporal degeneration.
The Cardio-Oncology Translational Center of Excellence at Penn Medicine has been awarded $2.9 million by the American Heart Association as part of a larger effort to reduce disparities in cardio-oncology and increase understanding of cardiovascular disease among cancer patients and survivors from minority populations. As part of this newly established research program, scientists from the University of Pennsylvania and other institutions will study patients with breast or prostate cancer, the most common cancers in women and men, respectively, with a focus on Black and Hispanic communities.
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