Joint statement empowers parents, young adults and physicians to act to increase vaccination rates and screenings to eliminate HPV-related cancers
St. Jude Children’s Research Hospital researchers have used systems biology approaches to reveal key details about regulation of immune function, including T cells that are central to cancer immunotherapy
Hospital invests more than $100 million in unique initiative aimed at accelerating efforts to improve childhood cancer survival rates worldwide
St. Jude Children’s Research Hospital researchers have identified a subtype of the brain tumor medulloblastoma that is associated with improved survival of infants treated with less aggressive, risk-adapted therapy
Researchers have created the first genetic screening guidelines for medulloblastoma patients after identifying gene variations that make carriers susceptible to develop the brain tumor and possibly other cancers
The 2018 American Association for Cancer Research (AACR) Annual Meeting features research, resources and expertise from St. Jude Children’s Research Hospital
St. Jude Children’s Research Hospital, in collaboration with Microsoft and DNAnexus, offers extensive next-generation sequencing data and unique analysis tools to accelerate research and cures for life-threatening pediatric diseases.
Chemotherapy agents have been associated with neurocognitive side effects in young leukemia survivors. Now St. Jude Children’s Research Hospital scientists have evidence the disease and genetics might also play a role.
St. Jude Children’s Research Hospital scientists have developed a new method to measure social networks of survivors of adolescent and young adult cancer in order to cultivate the health benefits of social connections
Research led by St. Jude Children’s Research Hospital offers the most comprehensive analysis yet of the genomic alterations leading to cancer in children and affirms the need for pediatric-specific precision therapies
Six years into Lebanon’s refugee crisis, St. Jude Children’s Research Hospital and the Children’s Cancer Center of Lebanon at the American University of Beirut Medical Center offer a blueprint for effective childhood cancer treatment during turmoil
Researchers in Memphis and Boston have collaborated to show c-MYC is an oncogene that drives neuroblastoma in some high-risk patients; the findings help set the stage for much-needed precision medicines
St. Jude Children’s Research Hospital oncologists have discovered the cell type that gives rise to rhabdomyosarcoma, the most prevalent soft tissue cancer in children. Previously, scientists thought the cancer arose from immature muscle cells, because the tumor resembled muscle under the microscope. However, the St. Jude researchers discovered the cancer arises from immature progenitors that would normally develop into cells lining blood vessels.
A study led by St. Jude Children’s Research Hospital found germline variations in a key tumor suppressor gene that may prompt changes in treatment and follow-up care for certain high-risk leukemia patients
St. Jude Children’s Research Hospital and Emory University research offers insight into origins of the T cells that provide enduring immune protection; findings should aid vaccine development and cancer immunotherapies
Preliminary findings indicate gene therapy pioneered at St. Jude Children’s Research Hospital is safe and effective for babies with a devastating inherited disorder that leaves them with little or no immune protection
St. Jude Children’s Research Hospital scientists report that combining the anti-malaria drug DHA with an emerging class of targeted agents may improve treatment of a high-risk acute lymphoblastic leukemia subtype
St. Jude Children’s Research Hospital researchers report that maximizing the dose of hydroxyurea increased levels of fetal hemoglobin and reduced the odds of hospitalizations for young sickle cell anemia patients.
St. Jude Children’s Research Hospital investigators said the results reinforce the importance of hand washing and other measures to help protect vulnerable patients from influenza infections.
Research led by St. Jude Children’s Research Hospital found meeting with fertility specialists and parental recommendations play key roles in decisions at-risk male cancer patients make about fertility preservation
St. Jude Children’s Research Hospital investigators report preventive antibiotic therapy, particularly with levofloxacin, reduced the odds of infections in at-risk pediatric leukemia patients early in cancer treatment
St. Jude Children’s Research Hospital analysis captures complexity and severity of chronic disease in childhood cancer survivors and suggests this growing population may benefit from more specialized health care delivery
St. Jude Children’s Research Hospital is offering the global scientific community no-cost access to an unprecedented collection of pediatric solid tumor samples and data to fuel research and move treatment forward
Research suggests health providers are key to boosting HPV vaccination rates of childhood cancer survivors, who, as a group, are at increased risk for second cancers associated with the human papillomavirus.
Research led by St. Jude Children’s Research Hospital highlights the importance of immune cell metabolism for maintaining a balanced immune response.
A team led by scientists at St. Jude Children’s Research Hospital and Mayo Clinic has identified a basic biological mechanism that kills neurons in amyotrophic lateral sclerosis (ALS) and in a related genetic disorder, frontotemporal dementia (FTD), found in some ALS patients. ALS is popularly known as Lou Gehrig’s disease. The researchers were led by J. Paul Taylor, M.D., Ph.D., chair of the St. Jude Cell and Molecular Biology Department and a Howard Hughes Medical Institute investigator; and Rosa Rademakers, Ph.D., of the Mayo Clinic in Jacksonville, Florida. The findings appear today in the journal Neuron.
St. Jude Children’s Research Hospital scientists have found that cells of a deadly acute myeloid leukemia can be killed by blocking production of a molecular “battery.”
Researchers led by St. Jude Children’s Research Hospital have identified a genetic variation associated with influenza severity and the supply of killer T cells that help patients fight the infection.
St. Jude Children’s Research Hospital has advanced understanding of risk factors for premature ovarian insufficiency, which should aid identification of cancer patients most likely to benefit from fertility preservation.
Charting the genomic landscape of T-lineage acute lymphoblastic leukemia patients revealed insights that will guide research and help to lay the foundation for more targeted therapy.
St. Jude Children’s Research Hospital discovery of the mechanism of T cell exhaustion will lead to treatments to enhance immunotherapies against cancers and such viruses as HIV
St. Jude Children’s Research Hospital and Fred Hutchinson Cancer Research Center have developed an algorithm that predicts T cell recognition of antigens and sets the stage to more effectively harness the immune system
St. Jude Children’s Research Hospital discovery of a regulatory enzyme working at the primary cilium could lead to treatments for the brain tumor medulloblastoma
St. Jude Children’s Research Hospital scientists have used a drug being developed to fight solid tumors to restore normal metabolism in flu-infected cells and reduce viral production without the threat of drug resistance
A map of the genome organization and DNA modifications that control growth of normal and cancerous retinal cells offers scientists a new path to understanding retinoblastoma and degenerative retinal diseases.
Mapping the biological machinery of the inflammatory skin disease neutrophilic dermatosis offers multiple targets for treating inflammatory disorders.
St. Jude Children’s Research Hospital scientists have regenerated immature auditory hair cells in adult mice by manipulating two genes. The research offers clues for better treatment of hearing loss.
St. Jude Children’s Research Hospital study examines origin of blood stem cells during development and offers clues for making “donor blood” in the laboratory for therapeutic use
A research team led by St. Jude Children’s Research Hospital immunologists has discovered how a set of proteins delays the “executioner” machinery that kills damaged or infected cells in a process called necroptosis.
St. Jude Children’s Research Hospital has completed the first whole genome sequencing of cancer survivors and found that 12 percent of childhood cancer survivors carry mutations linked to an increased risk of cancer
Inhibiting the Ezh2 enzyme may be counterproductive for treatment of certain cancers, including the aggressive brain tumor Group 3 medulloblastoma
Childhood cancer survivors are living longer. Now research shows they are also less likely to develop second cancers while still young. The decline followed a sharp drop in the use of radiation therapy for treatment of childhood cancers.
Esteemed clinician and scientist will oversee one of the world’s largest pediatric bone marrow transplantation programs.
International researchers led by St. Jude Children’s Research Hospital have identified genetic alterations that can be used to guide treatment of pediatric acute megakaryoblastic leukemia, which has a dismal prognosis.
A life-threatening infection in an infant with leukemia led to a St. Jude Children’s Research Hospital discovery of how prolonged infection sets the stage for bacterial persistence despite antibiotic susceptibility.
St. Jude Children’s Research Hospital researchers and collaborators reveal how a tumor-suppressing protein interacts with genetic enhancers to silence cancer genes in a newly developed model system
International research led by St. Jude Children’s Research Hospital shows the high-risk subtype Ph-like ALL accounts for almost 25 percent of ALL cases in adults and may be treatable with available targeted therapies.
A St. Jude Children’s Research Hospital analysis suggests that to improve patient safety, hospitals should focus on providing feedback to staff about changes resulting from past staff reports of safety-related events.
St. Jude Children’s Research Hospital – Washington University Pediatric Cancer Genome Project team identifies genetic changes underlying a type of B-precursor acute lymphoblastic leukemia
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