The American Society of Nephrology (ASN) is pleased to announce the winners of the new Midcareer Awards, which recognize nephrologists who have distinguished themselves in five key areas of accomplishment early in their careers.
• Combining the Renal Angina Index and measurement of urinary Neutrophil Gelatinase Associated Lipocalin can improve predictions of severe acute kidney injury in critically ill children. • Results from the study will be presented at ASN Kidney Week 2019 November 5–November 10 at the Walter E. Washington Convention Center in Washington, DC.
• Rates of kidney injury in women who are hospitalized during pregnancy are on the rise, especially in women with diabetes. • Results from the study will be presented at ASN Kidney Week 2019 November 5–November 10 at the Walter E. Washington Convention Center in Washington, DC.
• Patients receiving hemodialysis at facilities located in residential areas with a high percentage of Black residents have a higher rate of hospitalization. • Results from the study will be presented at ASN Kidney Week 2019 November 5–November 10 at the Walter E. Washington Convention Center in Washington, DC.
Dr. Agarwal will lead an organization of more than 20,000 health professionals from 131 countries dedicated to leading the fight against kidney diseases.
The American Society of Nephrology (ASN) will honor leaders in the fight against kidney disease during ASN Kidney Week 2019, the society’s annual meeting, held November 5–10 at the Walter E. Washington Convention Center in Washington, DC.
• Peritoneal dialysis performed with an automated wearable artificial kidney was safe and effective for removing toxins from the blood of patients with kidney failure. • Results from the study will be presented at ASN Kidney Week 2019 November 5–November 10 at the Walter E. Washington Convention Center in Washington, DC.
The results of numerous high-impact clinical trials that could affect kidney-related medical care will be presented at ASN Kidney Week 2019 November 5–November 10 at the Walter E. Washington Convention Center in Washington, DC.
• A home remote monitoring system may help track the health of patients on dialysis. • Results from the study will be presented at ASN Kidney Week 2019 November 5–November 10 at the Walter E. Washington Convention Center in Washington, DC.
• Few patients who start urgent and unplanned dialysis in clinical centers switch to home dialysis. The potential survival benefits of switching are unclear. • Results from the study will be presented at ASN Kidney Week 2019 November 5–November 10 at the Walter E. Washington Convention Center in Washington, DC.
• Extending Medicare coverage of anti-rejection medications beyond 36 months after a kidney transplant would lead to lower costs and an improvement in patients’ quality of life. • Results from the study will be presented at ASN Kidney Week 2019 November 5–November 10 at the Walter E. Washington Convention Center in Washington, DC.
• Many children with chronic kidney disease report fatigue and problems with sleep. • Sleep problems and fatigue were associated with lower executive functioning and more emotional-behavioral symptoms. • Results from the study will be presented at ASN Kidney Week 2019 November 5–November 10 at the Walter E. Washington Convention Center in Washington, DC.
• A machine learning model boosted rates of patients who started dialysis under optimal conditions. • Results from the study will be presented at ASN Kidney Week 2019 November 5– November 10 at the Walter E. Washington Convention Center in Washington, DC.
• Community house hemodialysis is a dialysis modality that overcomes many of the barriers to home hemodialysis. • Results from the study will be presented at ASN Kidney Week 2019 November 5– November 10 at the Walter E. Washington Convention Center in Washington, DC.
Briefing will feature presentations of High-Impact Clinical Trials. Dr. Pascale Lane and Dr. Kelly Hyndman will moderate and provide context and expert commentary on the science presented.
In patients taking immune checkpoint inhibitors as a treatment for cancer, 17% experienced acute kidney injury (AKI), 8% experienced sustained AKI, and 3% had potential immune checkpoint inhibitor–related AKI. • Use of proton pump inhibitors, which are commonly used to treat stomach ulcers or acid reflux, was associated with a higher risk of experiencing sustained AKI.
A new report from the Johns Hopkins University School of Medicine and the American Society of Nephrology found graduating nephrologists perceived improvements in job markets close to their training institutes. An increasing majority of nephrology fellows would recommend the specialty. The report also points to gender imbalances in base starting salaries and levels of educational debt.
American Society of Nephrology President Mark E. Rosenberg, MD, FASN, has issued the following statement regarding the new Kidney Care Choices Model: “The American Society of Nephrology (ASN) welcomes the introduction of the voluntary Kidney Care Choices (KCC) Model, and its four kidney care payment options, addressing key aspects of the Executive Order on Advancing American Kidney Health (AAKH). This voluntary model will be a true game changer and brings desperately needed, sweeping changes to care for people with kidney diseases. ASN has long advocated for key elements of this model, and I thank HHS Secretary Azar and his entire team for putting forward such a visionary approach for the future of kidney care.
Highlights • Rates for all types of kidney replacement therapy in European countries were consistently higher in men than women from 1965 to 2015. • Male-to-female ratios increased with age, showing consistency over decades and for individual countries, despite changes in the causes of kidney disease. • The male-to-female ratio was higher for kidney transplantation in diabetic patients.
The US Food and Drug Administration (FDA) has awarded a contract to the Kidney Health Initiative (KHI) to study patient preferences for innovative renal replacement therapy (RRT) devices. The three-year project, “Building Capacity to Incorporate Patient Preferences into the Development of Innovative Alternatives to Renal Replacement Therapy” will capture patient preference and risk tolerance data from people with kidney failure to drive innovations in RRT.
• In 2010-2016, many U.S. transplant centers commonly accepted deceased donor kidneys with less desirable characteristics. • The use of these organs varied widely across transplant centers, however, and differences were not fully explained by the size of waitlists or the availability of donor organs.
The American Society of Nephrology (ASN) is pleased to announce the establishment of the Burton D. Rose, MD, Endowed Lectureship.
The U.S. Department of Health and Human Services (HHS) Office of the Chief Technology Officer and the American Society of Nephrology (ASN) today introduced the members of the newly formed KidneyX Innovation Accelerator (KidneyX) steering committee. This diverse group of experts will play a critical role in advancing the KidneyX mission to improve the lives of the 850,000,000 people worldwide currently affected by kidney diseases by accelerating innovation in kidney disease prevention, diagnostics, and treatment.
• Compared with other pain medications, prescription opioids were linked with higher risks of death and hospitalization, particularly with higher doses. • The risk of death associated with opioids was highest among people with lower kidney function.
• The proportion of preemptive transplants—when a patient receives a kidney transplant before starting dialysis—increased after implementation of the 2014 Kidney Allocation System from 9.0% to 9.8% of all kidney transplants. • Increases in preemptive transplantation were not shared equally among all patient groups, however, and disparities were actually exacerbated for Black and Hispanic patients and for patients on Medicare.
• In an analysis of published studies, a healthy dietary pattern was associated with a 30% lower incidence of chronic kidney disease. • A healthy dietary pattern was also linked with a 23% lower incidence of albuminuria, an early indicator of kidney damage
• Kidney donation was linked with a 19% higher risk of developing hypertension, and this association did not vary by race. • Kidney function tended to improve after donation and then plateau if they developed hypertension.
• Researchers have uncovered 16 genetic regions linked to diabetic kidney disease. • The findings point to potential targets for prevention and treatment.
A recent analysis reveals that kidneys from donors infected with hepatitis C virus (HCV) are now routinely used in transplants at many U.S. centers, and they are functioning well one year after transplantation.
• In two different studies, researchers used machine learning algorithms to classify kidney biopsy samples and found substantial agreement with standard classification by pathologists • The methods may augment traditional diagnostics of kidney disease.
The Kidney Health Initiative (KHI), today announced the availability of two new resources to advance the global pursuit of an artificial kidney for use in humans. The US Department of Health and Human (HHS)’s Advancing American Kidney Health initiative made developing an artificial kidney a national priority through KidneyX and its Redesign Dialysis prize competition. KHI’s Technology Roadmap for Innovative Alternatives to Renal Replacement Therapy (RRT Technology Roadmap) established the foundational strategy for KidneyX and details the basic science requirements of an artificial kidney.
Patients with advanced chronic kidney disease who died in Department of Veterans Affairs’ facilities often received intensive patterns of end-of-life care that appeared to be primarily directed at life extension.
• Between 1996 and 2013, approximately 27% of adults, 21% of elderly adults, and 16% of children with kidney failure in the United States were hospitalized with a psychiatric diagnosis in the first year of kidney failure. • The prevalence of hospitalizations with psychiatric diagnoses increased over time across age groups, mostly due to secondary diagnoses.
The American Society of Nephrology (ASN) recently launched a new initiative aimed at saving lives of those who suffer from acute kidney injury (AKI). Made possible by a grant from Baxter Healthcare Corporation, the effort is called AKI!Now: Promoting Excellence in the Prevention and Treatment of Acute Kidney Injury.
• Brain aneurysms were detected by pre-symptomatic screening in 9% of patients with autosomal dominant polycystic kidney disease, more frequently in those with a history of hypertension and smoking. • Very few patients experienced aneurysmal ruptures, but the overall rupture rate was approximately 5 times higher than in the general population.
• The number of U.S. patients with kidney failure undergoing weight loss surgery increased 9-fold between 2006 and 2016. • The proportional use of sleeve gastrectomy in patients with kidney failure increased from less than 1% of weight loss surgeries in 2006 to 84% in 2016. • Complication rates for sleeve gastrectomy were similar between patients with and without kidney failure; however, patients with kidney failure had more hospital readmissions and slightly longer hospitals stays.
The American Society of Nephrology (ASN) is pleased to announce the launch of the Diabetic Kidney Disease Collaborative (DKD-C) in response to the recent development of new therapies for people with diabetic kidney disease (DKD). The Diabetic Kidney Disease Collaborative will work to increase coordination among primary care physicians, nephrologists, and other specialists to deliver appropriate therapies to people living with DKD.
• In an analysis of information on children with kidney failure who began dialysis in the United States between 1995 and 2015, the risk of death was 1.36 times higher among children with higher kidney function at dialysis initiation. • The risk of death was even greater for children with higher kidney function who initiated treatment with hemodialysis rather than peritoneal dialysis. • In more recent years, children have been started on dialysis with higher kidney function.
Among U.S. patients who started dialysis in 2005 to 2013, racial/ethnic differences in initiating home dialysis decreased over time, although in the most recent era, Blacks were still less likely to use home dialysis as the initial modality than other groups.
Washington, D.C. – July 11, 2019 – Today, the U.S. Department of Health and Human Services (HHS), American Society of Nephrology (ASN) and National Kidney Foundation (NKF) announced a new prize competition that seeks to identify ideas and solutions patients and care partners have developed to improve their daily life with kidney disease. The KidneyX Patient Innovator Challenge, funded by the National Kidney Foundation (NKF) invites individuals, communities, businesses, institutions, and not-for-profit organizations, among others, to submit ideas on how to improve therapeutic options and quality of life for people living with kidney disease.
•From 2006 to 2014, patients with chronic kidney disease (CKD) had a high prevalence of uncontrolled hypertension that did not decrease over time.
President Donald J. Trump and Department of Health and Human Services Secretary Alex Azar, II, today unveiled the Advancing American Kidney Health initiative.
The exclusion of patients with kidney diseases from clinical trials remains an unsolved problem that hinders optimal care of these patients. Over 850 million people suffer from kidney diseases worldwide, a number which signifies epidemic proportions, yet these patients are still ignored by investigators and initiators of clinical trials in all medical fields – and are thus excluded from clinical trials. ASN, ERA-EDTA and ISN, collaboratively aim to bring about a paradigm change in medical research and have launched an information campaign to that end.
• In older adults initiating dialysis at 17 centers in Netherlands, 40% experienced a decline in functional status, 34% remained stable, 18% improved, and 8% died within 6 months. • The risk of functional decline or death was higher in participants who were older and those who were frail. • The percentage of caregivers reporting a high burden of care increased from 23% to 38% after dialysis initiation.
• Among older living kidney donors, those with hypertension had higher risk of developing kidney failure through 15 years after donation; however, the absolute risk was small. • Hypertension was not linked with a higher risk of early death among older donors.
JASN maintains the highest impact ranking among kidney journals, according to a newly announced rating. Journal Citation Reports® (JCR) released its Impact Factor scores for 2018, and JASN earned a score of 8.5. This Impact Factor reflects the journal’s influence, based on the average annual number of citations in 2018 to articles published in a journal during 2016 and 2017. JASN was referenced more than any publication in the field.AMERICAN SOCIETY OF NEPHROLOGY JOURNALS MAINTAIN HIGH RANKING AND IMPACT AMONG KIDNEY JOURNALS Washington, DC (June 20, 2019)—JASN maintains the highest impact ranking among kidney journals, according to a newly announced rating. Journal Citation Reports® (JCR) released its Impact Factor scores for 2018, and JASN earned a score of 8.5. This Impact Factor reflects the journal’s influence, based on the average annual number of citations in 2018 to articles published in a journal during 2016 and 2017. JASN was referenced more than any publication in the f
• A restrictive approach to blood cell transfusions in patients undergoing cardiopulmonary bypass surgery led to fewer transfusions than a more liberal approach, without any increased risk of acute kidney injury. • The results were consistent in patients with and without chronic kidney disease before surgery.
The ASN Foundation for Kidney Research announced the 2019 recipients of research grants to advance new understandings of—and treatments for—kidney diseases. The Foundation will fund 46 leading researchers working to cure kidney diseases. These include 27 new projects, with 19 continuing from 2018. Established in 2012 by the American Society of Nephrology, the Foundation funds research that will help improve the health of approximately 40 million Americans burdened by kidney diseases, the 9th leading cause of death in the United States.
• In a study of patients with chronic kidney disease who did or did not wear medical-alert bracelets or necklaces, the frequency of safety events—or unintended harm from medical therapy—reported at annual visits was not different in the 2 groups. • Wearing a medical-alert accessory was linked with a 62% lower risk of developing kidney failure, after adjustments. • There was no significant difference in rates of hospitalization or death in those who did and did not wear medical-alert accessories.
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