A sugar-loving protein drives the growth of Kaposi sarcoma tumors. Interfering with these sugary interactions inhibited growth of Kaposi sarcomas in mice, hinting at the potential for new treatment strategies in humans.
Just as users of Google Earth can zoom in from space to a view of their own backyard, researchers can now navigate biological tissues from a whole embryo down to its subcellular structures thanks to recent advances in electron microscopy and image processing, as described in The Journal of Cell Biology (JCB).
Injection of a small amount of clumped protein triggers a cascade of events leading to a Parkinson’s-like disease in mice, according to an article in the Journal of Experimental Medicine.
The Journal of General Physiology has introduced an exciting new feature to expand the online presentation of scientific articles. The Video Summary is an optional tool that authors can use to highlight the main results of their research in a compelling format for JGP audiences.
Targeting a single protein can help fight both breast cancers and leukemias, according to two reports published online on January 23 in the Journal of Experimental Medicine.
Stabilizing the cell’s power-generating center protects against Parkinson’s disease (PD) in a rat model, according to a report published online this week in the Journal of Experimental Medicine.
One kind of leukemia sometimes masquerades as another, according to a study in the Journal of Experimental Medicine.
Scientists have pinpointed a protein that allows brains tumors to invade healthy brain tissue, according to work published in the Journal of Experimental Medicine.
The Rockefeller University Press (RUP) has unveiled new iPhone and iPad apps for its three journals: The Journal of Cell Biology (JCB), The Journal of Experimental Medicine (JEM), and The Journal of General Physiology (JGP). iPhone, iPad, and iPod touch users can read full-text articles anywhere at any time, even without an Internet connection.
Prostate tumor cells can be lulled to sleep by a factor released by bone cells, according to a study published online this week in the Journal of Experimental Medicine.
Sluggish recycling of a protein-slicing enzyme could promote Alzheimer’s disease, according to a new study in The Journal of Cell Biology.
Two proteins conspire to promote Lou Gehrig’s disease, according to a study published in the Journal of Experimental Medicine.
The neurodegeneration associated with Alzheimer's disease is thought to be caused by small, soluble A-beta complexes, partly through their ability to induce excess calcium influx into cells, which stimulates cell death. A new study reveals that A-beta oligomers elevate calcium by forming calcium-permeable pores in the plasma membrane.
Differences in the levels of two key metabolic enzymes may explain why some people are more susceptible to liver damage, according to a study in the October 17 issue of The Journal of Cell Biology (www.jcb.org).
Cells making slippery mucus provide a sticking point for disease-causing bacteria in the gut, according to a study published on October 3 in the Journal of Experimental Medicine.
Tumors have an arsenal of tricks to help them sidestep the immune system. A study published on September 19 in the Journal of Experimental Medicine reveals a new trick—the ability to keep tumor-fighting T cells out by disabling a T cell–attracting protein within the tumor core.
Blocking a growth factor receptor cripples cancer growth in a form of T cell leukemia, according to a study published online on August 1 in the Journal of Experimental Medicine (www.jem.org).
A new study describes how hyperactivation of AMP-activated protein kinase (AMPK) promotes neurodegeneration in Huntington’s disease (HD). The article appears online on July 18, 2011, in The Journal of Cell Biology.
A small protein called SUMO might prevent the protein aggregations that typify Parkinson’s disease (PD), according to a new study in the July 11, 2011, issue of The Journal of Cell Biology.
The Aurora A kinase may contribute to polycystic kidney disease (PKD) by inactivating a key calcium channel in kidney cells, according to a study in the June 13 issue of The Journal of Cell Biology.
A paper published online on June 13 in the Journal of Experimental Medicine identifies new gene mutations in patients with chronic lymphocytic leukemia (CLL)—a disease often associated with lack of response to chemotherapy and poor overall survival.
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