Retired firefighter Roger McCurley had an artificial urinary sphincter (AUS) implanted at UT Southwestern’s William P. Clements Jr. University Hospital in Dallas to alleviate urinary leakage following prostate cancer surgery.
More than 20 UT Southwestern Medical Center scientists are among the 2022 Highly Cited Researchers listed in the top 1% of researchers from across the globe
Preclinical study suggests that a class of new drugs already in clinical trials might work especially well in breast cancer patients who have acquired the so-called Y537S mutation signals that their disease has taken an aggressive course and may become resistant to endocrine therapy
A small group of brain cells linked in a circuit is responsible for setting off whole-brain seizures in a rare form of epilepsy affected by blood sugar levels, a study led by UT Southwestern researchers suggests. The finding, published in Science Translational Medicine, could lead to new treatments for other metabolic disorders in the brain, the authors said.
Many U.S. service members struck by ground explosives during the conflicts in Iraq and Afghanistan suffered genitourinary (GU) injuries to their urinary, genital, and reproductive systems
Magnetic resonance imaging (MRI) can reliably establish measurements for anterior cruciate ligament (ACL) “footprints” that are critical to the placement of grafts for reconstruction surgery
UTSW pediatric pulmonologist highlights how to reduce risk of serious asthma attack
Curbing depression among caregivers improves control of asthma and lung function in children
A normal process called cell competition, in which healthy tissues eliminate unhealthy cells, could be responsible for cancer relapses in patients months or years after they were declared cancer-free
The Perot family, The Perot Foundation, and The Sarah and Ross Perot, Jr. Foundation have provided a transformative $50 million endowment for UT Southwestern’s Medical Scientist Training Program (MSTP), among the nation’s elite programs that provide graduates a dual M.D./Ph.D. degree to strengthen the advancement of laboratory discoveries into the clinical arena. Funding will provide a permanent endowment for the Perot Family Scholars Medical Scientist Training Program – one of just 54 M.D./Ph.D. training programs in the country supported by the National Institutes of Health (NIH).
A recent viral video showing a California ophthalmologist removing 23 contact lenses from an elderly patient’s eye has drawn attention to the importance of properly using contact lenses to ensure the health of your eyes.
Vaginal progesterone, a hormone treatment considered the standard of care for preventing preterm birth in at-risk pregnant women, may not be effective, according to UT Southwestern Medical Center researchers.
UT Southwestern researchers have identified a causative signaling pathway in breast cancer, providing potential new targets for treatment of the most common type of cancer in women.
A multidisciplinary effort to improve care for older patients who arrive at the emergency room with a hip fracture has decreased the time before they have surgery, shortened hospital stays, and resulted in better follow-up care
UT Southwestern Medical Center has received exemplar status by the Nurses Improving Care for Healthsystem Elders (NICHE) – an international designation that indicates a hospital's commitment to achieving the highest level of geriatric care excellence.
For the third year in a row, UT Southwestern is ranked as the top health care institution globally by Nature Index for publishing high-quality research in all subjects and in the life sciences.
Measuring levels of a specific brain wave could lead to more objective, definitive methods of diagnosing concussions and determining when young athletes can safely return to play, according to a UT Southwestern stud
The most common bacterial infection to occur after revision shoulder arthroplasty surgery can be diagnosed more accurately by considering how quickly samples of the microbe grow in hospital labs and the level of bacteria that grows.
A drug approved to treat breast cancer patients with mutations in the BRCA1 or BRCA2 genes may also benefit people who have other genetic mutations.
A faulty gene, rather than a faulty diet, may explain why some people gain excessive weight even when they don’t eat more than others, UT Southwestern researchers at the Center for the Genetics of Host Defense have discovered.
UT Southwestern Medical Center ranked fourth in the nation and No. 1 in Texas for commercializing new biomedical technologies
The discovery that different bone-forming stem cells are responsible for different aspects of bone maintenance and repair will allow us to focus future bone regeneration efforts
New research from pediatricians at UT Southwestern and Children's Health reveals the impact of COVID-19 on mental health in children.
UTSW study suggests combination therapy might help prostate cancer patients overcome resistance to current treatments
The National Academy of Medicine today announced the election of two UT Southwestern Medical Center faculty members – Lora Hooper, Ph.D., Chair of Immunology, and Zhijian “James” Chen, Ph.D., Professor of Molecular Biology and Director of the Center for Inflammation Research – one of the highest honors attainable in the fields of health and medicine.
Physicians at the UT Southwestern Spine Center are now offering a minimally invasive ablation procedure to provide relief for low back pain caused by injury or degeneration of the vertebral endplates.
Despite decades of medical advances, children who develop the pediatric eye cancer retinoblastoma often lose their vision or an eye due to a lack of specific, targeted therapies and a poor molecular understanding of the cancer. Now researchers at UT Southwestern and the University of Miami have discovered that a molecule – estrogen-related receptor gamma, or ESRRG – becomes hyperactive and promotes tumor cell survival in retinoblastoma. Blocking ESRRG, the team reported in Science Advances, kills retinoblastoma cells.
An enzyme called Fic, whose biochemical role was discovered at UT Southwestern more than a dozen years ago, appears to play a crucial part in guiding the cellular response to stress, a new study suggests. The findings, published in PNAS, could eventually lead to new treatments for a variety of diseases.
Fat cells, or adipocytes, that grow in close proximity to breast cancers can shift into other cell types that promote tumor growth, a new study by UT Southwestern researchers suggests. The findings, published in Cell Reports, could lead to new ways to fight breast cancer, a disease that is diagnosed in more than 300,000 U.S. women each year and kills nearly 45,000 annually.
Thousands of residents, business owners, and regional leaders gathered Saturday at the community celebration for the opening of UT Southwestern Medical Center at RedBird, the largest of its regional campuses and the first to bring academic medicine to the booming southern Dallas region.
Low-income seniors were seven times more likely to visit a food pantry in the year after becoming eligible for Medicare, resulting in improved food security, according to a new study from UT Southwestern.
The National Cancer Institute (NCI) has renewed UT Southwestern’s Harold C. Simmons Comprehensive Cancer Center Kidney Cancer Program (KCP) Specialized Program of Research Excellence (SPORE) award. First awarded in 2016, the KCP SPORE is focused on translating discoveries and innovation at UT Southwestern into advances in patient care.
Blocking the inhibition of PKD1 and PKD2 gene expression by deleting a binding site for microRNAs hindered the formation and growth of kidney cysts in autosomal dominant polycystic kidney disease (ADPKD) models, UT Southwestern researchers reported. The findings, published in Nature Communications, suggest a strategy for gene therapy with the potential to arrest or cure ADPKD.
A set of interacting molecules in immune cells of the gut is responsible for preventing the inflammation seen in inflammatory bowel diseases (IBD), UT Southwestern researchers report in a new study. The findings, published in Cell Reports, suggest a new drug target for treating IBD and related conditions.
Two UT Southwestern postdoctoral fellows – Gabriel Muhire Gihana, Ph.D., and Victor Lopez, Ph.D. – are among 25 early career scientists in the United States selected as 2022 Hanna H. Gray Fellows. The fellowship program, run by the Howard Hughes Medical Institute (HHMI), aims to increase diversity in the biomedical sciences by recruiting and retaining individuals from underrepresented groups in the life sciences and disadvantaged backgrounds.
The role of the microbiome in intestinal and systemic health has garnered close attention among researchers for many years. Now evidence is mounting that this collection of microorganisms in the human gut can also impact a person’s neurological and emotional health, according to a recent perspective article in Science by a UT Southwestern researcher.
Using a genetic screening platform developed by a UT Southwestern Nobel Laureate, scientists with the Center for the Genetics of Host Defense at UT Southwestern Medical Center have identified genetic mutations that contribute to nonalcoholic fatty liver disease (NAFLD), providing a potential future target for therapeutic interventions.
Culinary medicine programs are emerging at medical schools to meet a critical need to improve nutrition education in an era of unprecedented diet-related health problems including obesity and cardiovascular disease, according to a review of programs by UT Southwestern researchers published in Academic Medicine, the journal of the Association of American Medical Colleges.
A new study by UT Southwestern’s Simmons Cancer Center scientists suggests that lactate, a metabolic byproduct produced by cells during strenuous exercise, can rejuvenate immune cells that fight cancer. The finding, published in Nature Communications, could eventually be used to develop new strategies to augment the anti-tumor effect of cancer immunotherapies, the study authors said.
Summertime means lots of opportunities for fun in the sun. But this year’s high temperatures also bring an increased risk of dehydration that can cause urinary tract infections (UTIs), said Maude Carmel, M.D., Associate Professor of Urology at UT Southwestern Medical Center. These common infections are marked by a burning sensation or pain with urination, increased urinary frequency, urinary urgency, and blood in the urine (a condition called hematuria).
Breastfeeding offers a wealth of benefits both for mothers and their babies. Although diabetes can complicate the process, it does not prevent mothers from giving their babies this wonderful start to life, according to UT Southwestern endocrinologist Maria Ramos-Roman, M.D., Associate Professor of Internal Medicine.
A multidisciplinary effort to improve care for older patients who arrive at the emergency room with a hip fracture has decreased the time before they have surgery, shortened hospital stays, and resulted in better follow-up care, UT Southwestern physicians reported in Geriatric Nursing.
A single mutation in a gene, Kcnc3, which encodes a potassium channel in neurons, causes learning deficits in mice, UT Southwestern researchers report in a new study in PNAS. The novel mutation decreases the activity of neurons in the hippocampus, the area of the brain important for learning and memory, and highlights a new role for potassium channels.
The earlier individuals develop Type 2 diabetes or hypertension in life, the earlier they are likely to develop primary open-angle glaucoma (POAG), the leading cause of irreversible blindness worldwide, researchers from UT Southwestern reported in a recent study. The findings, published in Clinical Ophthalmology, could lead to better screening protocols for POAG, which accounts for up to 90% of all cases of glaucoma.
Following Enhanced Recovery After Surgery (ERAS) protocols designed to minimize surgical stress results in improved patient recovery and satisfaction, reduced postoperative complications, and shorter hospital stays, according to a review of ERAS programs in minimally invasive gynecologic surgery by UT Southwestern researchers.
Kidney cancer encompasses a wide spectrum and can present with extensive metastases or just a handful. However, today all patients are treated the same. They all receive medication.
With antibiotic-resistant bacteria on the rise, scientists have been searching for ways to shut down the Type IV secretion system (T4SS), a protein complex on the outer envelope of bacterial cells that helps them to exchange DNA with neighboring bacteria and resist antibiotics.
Using UT Southwestern’s Cryo-Electron Microscopy Facility, researchers have captured images of an enzyme for Wnt lipidation, which is pivotal to human development and cancer and crucial for Wnt signaling activation. The findings, reported in Nature, shed light on the mechanisms behind this activity and could eventually lead to new drugs to treat various malignancies.
A new imaging device at UT Southwestern is making complex aortic repairs safer for patients and operating room staff by dramatically reducing their exposure to radiation. The device, known as Fiber Optic RealShape (FORS) and manufactured by Philips, uses light to visualize blood vessels, nearly eliminating the need for X-rays typically used during minimally invasive vascular procedures.
A team led by UT Southwestern researchers has identified how SARS-CoV-2, the virus that causes COVID-19, builds a structure called the RNA cap that’s critical for successful viral replication. The finding, published in Nature, could lead to new strategies to attack COVID-19, which has sickened nearly 600 million and killed more than 6 million worldwide thus far.
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