Low Levels of Donor-Specific Antibodies Increase Risks for Transplant Recipients

Released: 11/9/2012 9:00 AM EST
Embargo expired: 11/15/2012 5:00 PM EST
Source Newsroom: American Society of Nephrology (ASN)
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Citations Journal of the American Society of Nephrology (doi: 10.1681/2012070664)

Findings could help provide better donor-recipient matches and tailor recipients’ treatments after kidney transplantation

Highlights
• The detection of preformed donor-specific antibodies by newer tests, despite negative results from traditional tests, nearly doubles a kidney transplant recipient’s risk for rejection.
• It also increases the risk of kidney failure by 76%.

Nearly 17,000 kidney transplants take place each year in the United States.

Newswise — Washington, DC (November 15, 2012) — Kidney transplant recipients who have even very low levels of preformed antibodies directed against a donated kidney have a significantly increased risk of organ rejection and kidney failure, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). The findings could help clinicians provide better donor-recipient matches and tailor recipients’ immunosuppressive therapy after transplantation.

Transplant recipients who have had previous transplants, blood transfusions, and other sensitizing events often have antibodies directed against a particular donor’s kidney. These antibodies can increase the risk of organ rejection and kidney failure. But at what level do these antibodies put recipients at increased risk? Some newer tests, called solid phase assays, can detect them at much lower blood concentrations than traditional tests.

To investigate, Sumit Mohan, MD, Amudha Palanisamy, MD (Columbia University Medical Center) and their colleagues pored through the medical literature to find studies that looked at the health outcomes of kidney transplant recipients with such preformed donor-specific antibodies. Their search identified seven studies that included 1,119 patients.

Together, the results of these studies suggest that the detection of donor-specific antibodies by newer tests, despite negative results from older tests, nearly doubles the risk for antibody-mediated rejection and increases the risk of kidney failure by 76%. (The absolute risk of failure in the first year in the United States is currently about 8.2% for first-time recipients and about 10.7% for repeat transplant recipients.)

“Our study quantifies the level of risk associated with antibodies detected at the time of transplantation, helping clinicians better understand the prognosis and the risk of failure, thereby allowing for appropriate tailoring of immunosuppressive therapy,” said Dr. Mohan. It also suggests that donor selection processes should take into consideration the presence of antibodies in the recipient, as identified by newer, more sensitive tests.

Study co-authors include Demetra Tsapepas, PharmD, Bekir Tanriover, MD, R. John Crew, MD, Geoffrey Dube, MD, Lloyd E Ratner, MD, David Cohen, MD, and Jai Radhakrishnan, MD.

Disclosures: The authors reported no financial disclosures.

The article, entitled “Donor-Specific Antibodies Adversely Impact Kidney Allograft Outcomes,” will appear online at http://jasn.asnjournals.org/ on November 15, 2012, doi: 10.1681/2012070664.

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