Credit: UNC/Marzluff Lab
Research by William F. Marzluff at the UNC School of Medicine discovered the process by which cellular intermediaries degrade histone mRNA after it has performed its role in cell reproduction. An alternating set of protein complexes – a TUTAse (a uridine adding enzyme) and a nuclease, the exosome, with help from the DOM34/Hbs1 complex - progressively break down RNA, priming and restarting the process until the RNA is completely destroyed.