Credit: Image courtesy of Plexxikon Inc.
This image shows how the drug (PLX7904) binds to a specific site in the mutant BRAF protein (the rest of the image), where it has the effect of disrupting the processes that promote cancer growth. The macromolecule backbone and nearest amino acids are schematically represented, with the carbon atoms in the drug colored green. A dotted surface shows how a particular group in the PLX7904 is in close contact with the Leu505 of the aC helix.