Xin Zou/Penn State
Lipid nanoprobes (blue, green and yellow colored) spontaneously insert into lipid bilayer of three extracellular vesicles. The cargo content of extracellular vesicles includes proteins, DNA and RNA. The lipid nanoprobe-labeled extracellular vesicles are captured onto the surface of a magnetic bead (black, bottom) through interaction with conjugated avidin molecules (red). Exosome isolation and its cargo analysis offers new opportunities for a diverse range of molecular analyses, including mutation detection from blood plasma of cancer patients.