Credit: Yong Kim and Mitch Lazar, Perelman School of Medicine, University of Pennsylvania
Schematic of Rev-erb’s role in gene expression. At night (left), when Rev-erb concentration decreases, gene expression is turned on by protein complexes that loop the chromosome bringing together distant regions (blue and pink). During the day (right), when Rev-erb levels rise, the protein complexes are kicked out, causing the loop to loosen and turn off gene expression.