Credit: Mei Wan
Left: Young mice, before puberty (2 weeks old), have many nestin-positive (green) mesenchymal stem cells (MSCs) in the primary spongiosa to maintain or build bone mass during bone elongation initiated by the growth plate above. Right: Mice treated with the glucocorticoid prednisolone are missing that population of cells, contributing to the development of osteoporosis. The nuclei of cells are shown in blue