Credit: Credit: Dr. Chunli Yan and Tom Dodd, Georgia State University
Thymine DNA glycosylase (TDG) in complex with DNA is shown on the top left panel. Free energy profile for the TDG-induced base flipping is shown in the top right panel. Structures of the flipped out DNA base interacting the enzyme at various intermediate states are shown and mapped onto the base flipping path (as indicated by arrows).