Menthol Increases Nicotine Exposure, Worsens Addiction

Article ID: 629899

Released: 18-Feb-2015 8:00 AM EST

Source Newsroom: Duke Health

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  • Credit: Duke Medicine

    Sven-Eric Jordt

In a study published last week in the journal PLOS ONE, researchers at Duke University and the University of Connecticut found that the menthol in cigarettes reduces irritation of the airways and increases a critical marker of nicotine exposure: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0117128

The finding could provide scientific evidence for the FDA as it considers whether to regulate menthol cigarettes, which are especially popular with young, beginning smokers and with minority populations, notably African-Americans. While the number of smokers has declined, the number of menthol smokers has remained steady, and menthol smokers have more difficulties quitting.

The study, conducted in mice, shows that menthol appears to suppress smoke-induced irritation, makings it easier to inhale smoke and increasing the dosage of nicotine. Due to the similarities in menthol's pharmacology in humans, the animal models suggest that beginning smokers likely prefer menthols since they feel less irritated. At the same time, these smokers are exposed to higher levels of nicotine and become addicted faster and more durably.

Dr. Sven-Eric Jordt, Ph.D.: Dr. Jordt joined the Department of Anesthesiology at Duke University Medical School from Yale University, where he directed a pain research laboratory for nine years. Jordt’s laboratory at Duke focuses on mechanisms of pain, irritation, and analgesia, and on the role of peripheral sensory neurons in inflammation.

Statement: "Menthol may increase the numbers of smokers – they get addicted quicker and have a harder time quitting. It's a tool to make people addicted."


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