Scientists Discover Gene that May Halt Cancer Spread

Newswise — Researchers at Roswell Park Cancer Institute (RPCI) have discovered a gene that shows promise in halting the spread of cancer cells. Labeled SSeCKS/Gravin/AKAP12, the gene was discovered by Roswell Park researcher Irwin Gelman, PhD, vice chair of the Department of Cancer Genetics at RPCI, and colleagues in his lab. An article about the discovery is featured on the cover of the March 2006 issue of Molecular Cancer Research.

Identification of the gene is significant because most cancer deaths are caused by cancer that has spread, or metastasized. Gelman's team found that the gene suppressed the formation of structures called "podosomes," which malignant cancer cells use to spread into nearby organs. Research can now focus on developing treatments to boost the gene's effectiveness in halting the spread of cancer.

Roswell Park Cancer Institute, founded in 1898, is the nation's first cancer research, treatment and education center and is the only National Cancer Institute-designated comprehensive cancer center in Upstate New York. RPCI is a member of the prestigious National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers. For more information, visit the RPCI website at http://www.roswellpark.org, call 1-877-ASK-RPCI (1-877-275-7724) or e-mail [email protected].