The American Journal of Geriatric Psychiatry March 2009 Table of Contents

EDITORIAL

Brain and Cognitive Reserve, Perminder S. Sachdev, M.D., Ph.D., F.R.A.N.Z.C.P., Michael Valenzuela, B.Sc. Hons., M.B.B.S. Hons., Ph.D.

REGULAR RESEARCH ARTICLES

Can Cognitive Exercise Prevent the Onset of Dementia? Systematic Review of Randomized Clinical Trials with Longitudinal Follow-up, Michael Valenzuela, B.Sc. Hons., M.B.B.S. Hons., Ph.D., Perminder Sachdev, M.D., Ph.D., F.R.A.N.Z.C.P.

Fluoro-Deoxy-Glucose Positron Emission Tomography Correlates of Impaired Activities of Daily Living in Dementia With Lewy Bodies: Implications for Cognitive Reserve, Robert Perneczky, M.D., Peter Ha¨ussermann, M.D., Alexander Drzezga, M.D., Henning Boecker, M.D., Oliver Granert, Ph.D., Regina Feurer, M.D., Hans Fo¨rstl, M.D., Alexander Kurz, M.D.

Modeling Brain Reserve: Experience-Dependent Neuronal Plasticity in Healthy and Huntington's Disease Transgenic Mice, Jess Nithianantharajah, Ph.D., Christopher Barkus, M.Sc. (Hons), Nirosen Vijiaratnam, B.Med.Sc., Olivier Clement, M.Sc., Anthony J. Hannan, Ph.D.

Simulation of Neuronal Death and Network Recovery in a Computational Model of Distributed Cortical Activity, Mikail Rubinov, M.B.B.S., Anthony R. McIntosh, Ph.D., Michael J. Valenzuela, B.Sc. Hons, M.B.B.S. Hons, Ph.D., Michael Breakspear, M.B.B.S., Ph.D.

Education, Atrophy, and Cognitive Change in an Epidemiological Sample in Early Old Age, Helen Christensen, Ph.D., Philip J. Batterham, M.P.H., Andrew J. Mackinnon, Ph.D., Kaarin J. Anstey, Ph.D., Wei Wen, Ph.D., Perminder S. Sachdev, M.D., Ph.D.

Mentally Stimulating Activities at Work During Midlife and Dementia Risk After Age 75: Follow-Up Study From the Kungsholmen Project, Anita Karp, Ph.D., Ross Andel, Ph.D., Marti G. Parker, Ph.D., Hui-Xin Wang, Ph.D., Bengt Winblad, M.D., Ph.D., Laura Fratiglioni, M.D., Ph.D

The Epidemiology of Substance Use and Disorders Among Middle Aged and Elderly Community Adults: National Survey on Drug Use and Health, Dan G. Blazer, M.D., Ph.D., Li-Tzy Wu, Sc.D.

Spousal Suffering and Partner's Depression and Cardiovascular Disease: The Cardiovascular Health Study, Richard Schulz, Ph.D., Scott R. Beach, Ph.D., Randy S. Hebert, M.D., Lynn M. Martire, Ph.D., Joan K. Monin, Ph.D., Connie A. Tompkins, Ph.D., Steven M. Albert, Ph.D.

Sensitivity of Older Patients to Antipsychotic Motor Side Effects: A PET Study Examining Potential Mechanisms, Hiroyuki Uchida, M.D., Ph.D., Shitij Kapur, M.D., Ph.D., F.R.C.P.C., Benoit H. Mulsant, M.D., M.S., F.R.C.P.C., Ariel Graff-Guerrero, M.D., Ph.D., Bruce G. Pollock, M.D., Ph.D., F.R.C.P.C., David C. Mamo, M.D., M.Sc., F.R.C.P.C.

About The American Journal of Geriatric Psychiatry

Rated as one of the top ten journals in geriatrics and gerontology, The Journal of the American Academy of Geriatric Psychiatry, the official journal of the American Association for Geriatric Psychiatry, is the forum for the latest information in this rapidly developing field. Published monthly, AJGP keeps you up to date on the latest clinical and experimental findings, engages the reader in a global dialogue on the future direction of geriatric psychiatry like no other journal and is recognized worldwide as a leading journal in the field. Visit the journal's web page at www.AJGPonline.org

About Lippincott Williams & Wilkins

Lippincott Williams & Wilkins (LWW) is a leading international publisher for healthcare professionals and students with nearly 300 periodicals and 1,500 books in more than 100 disciplines publishing under the LWW brand, as well as content-based sites and online corporate and customer services. LWW is part of Wolters Kluwer Health, a leading provider of information and business intelligence for students, professionals and institutions in medicine, nursing, allied health, pharmacy and the pharmaceutical industry.

Wolters Kluwer Health is a division of Wolters Kluwer, a leading global information services and publishing company with annual revenues (2007) of €3.4 billion ($4.8 billion), maintains operations in over 33 countries across Europe, North America, and Asia Pacific and employs approximately 19,500 people worldwide. Visit www.wolterskluwer.com for information about our market positions, customers, brands, and organization.